PURDUE UNIVERSITY
PURDUE UNIVERSITY
PURDUE UNIVERSITY
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<strong>PURDUE</strong> 1<br />
<strong>PURDUE</strong> <strong>UNIVERSITY</strong><br />
575 Stadium Mall Drive, MCMP Dept, 1333 Robert E.<br />
Heine Pharmacy Building, Room 202<br />
West Lafayette, IN 47907-2091<br />
TEL: (765) 494-1403<br />
FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu<br />
Email: borch@purdue.edu<br />
Department of Medicinal Chemistry and Molecular<br />
Pharmacology<br />
Richard F. Borch, M.D., Ph.D., Department Head.<br />
Degrees Offered: M.S, Ph.D.<br />
Fields of Specialization: Medicinal Chemistry, Pharmacology.<br />
Interdisciplinary Program: Cancer Research Center,<br />
Purdue University Interdisciplinary Life Science PhD<br />
Program (PULSe).<br />
bonds catalyzed by palladium: An efficient approach for high<br />
throughput optimizations and kinetic studies, Advanced Synthesis<br />
& Catalysis, 350, 71-75 (2008).<br />
Shiyue Fang, Yousheng Guan, Ernest R. Blatchley, Chengyue<br />
Shen and Donald E. Bergstrom, Conjugation of (E)-5-<br />
[2-(Methoxycarbonyl)ethenyl]cytidine to Hydrophilic Microspheres:<br />
Development of a Mobile Microscale UV Light Actinometer,<br />
Bioconjugate Chem, 19, 592-597 (2008).<br />
Mohammad Ahmadian and Donald E. Bergstrom, 5-substituted<br />
nucleosides in biochemistry and biotechnology, Modified<br />
Nucleosides in Biochemistry, Biotechnoloy and Medicine,<br />
P. Herdewijn, ed. Wiley-VCH, Weinheim, 251-276<br />
(2008).<br />
E. R. Blatchley III, C. Shen , O. K. Scheible, J. P. Robinson,<br />
K. Ragheb, D. E. Bergstrom and D. Rokjer, Validation<br />
of large-scale, monochromatic UV disinfection systems for<br />
drinking water using dyed microspheres, Water Research,<br />
42, 677-688 (2008).<br />
S. Abd-El-Mawla, Azocarboxamide ribonucleoside tri-<br />
phosphates: synthesis, site-specific incorporation into RNA<br />
and incorporation studies with bovine diarrhea virus polymerase.<br />
(D)<br />
Email: cjchang@pharmacy.purdue.edu<br />
John M. Pezzuto, Richard C. Moon, Charles K.-H. Chang<br />
and Ching-jer Chang, New approach for evaluating the antibreast<br />
cancer activity of traditional Chinese medicine, Annals<br />
of Traditional Chinese Medicine, 3, 321-346 (2007).<br />
Her-Shyong Shiah, Wan-Shu Lee, Shin-Hun Juang, Pao-<br />
Chiung Hong, Chia-Chi Lung, Ching-Jer Chang, Kai-Ming<br />
Chou and Jang-Yang Chang, Mitochondria-mediated and<br />
p53-associated apoptosis induced in human cancer cells by a<br />
novel selenophene derivative, D-501036, Biochem. Pharma-<br />
col, 73, 610-619 (2007).<br />
Shin-Hun Juang, Chia-Chi Lung, Pi-Chen Hsu, Kuo-Shun<br />
Hsu, Yu-Chen Li, Pao-Chiung Hong, Her-Shyong Shiah,<br />
Ching-Chuan Kuo, Ching-Wei Huang, Yu-Chin Wang, Leey-<br />
uan Huang, Tom S. Chen, Shyh-Fong Chen, Kuo-Chu Fu,<br />
Cheng-Li Hsu, Meng-Ju Lin, Ching-jer Chang, Curtis L.<br />
Ashendel, Thomas C. K. Chan, Kai-Ming Chou and Jang-<br />
Yang Chang, D-501036, a novel selenophene-based triheter-<br />
ocycle derivative, exhibits potent in vitro and in vivo antitumoral<br />
activity which involves DNA damage and ataxia telangiectasia-mutated<br />
nuclear protein kinase activation, Mol.<br />
Cancer Ther, 6, 193-202 (2007).<br />
ASHENDEL, CURTIS L. (b.1955) Associate Professor.<br />
B.S, 1977, Michigan State University; Ph.D, 1982,<br />
University of Wisconsin, Madison. Bioinformatics; Molecular<br />
Biology. Current interest is computational genomics<br />
and systems biology. Specific interest is in sup-<br />
plementing genomic modeling and analysis algorithms<br />
with automated scientific reasoning. Cellular regulatory<br />
systems are my primary specific application area, includ-<br />
ing gene regulatory networks. Major applications include<br />
mechanisms of oncogenesis and other common human<br />
diseases, including type II diabetes. TEL: (765) 494-<br />
1479 FAX: (000) 000-0000<br />
Web: www.mcmp.purdue.edu/faculty/ashendel.php<br />
Email: ashendel@purdue.edu<br />
Shin-Hun Juang, Chia-Chi Lung, Pi-Chen Hsu, Kuo-Shun<br />
Hsu, Yu-Chen Li, Pao-Chiung Hong, Her-Shyong Shiah,<br />
Ching-Chuan Kuo, Ching-Wei Huang, Yu-Chin Wang, Leey-<br />
uan Huang, Tom S. Chen, Shyh-Fong Chen, Kuo-Chu Fu,<br />
Cheng-Li Hsu, Meng-Ju Lin, Ching-jer Chang, Curtis L.<br />
Ashendel, Thomas C. K. Chan, Kai-Ming Chou and Jang-<br />
Yang Chang, D-501036, a novel selenophene-based triheter-<br />
ocycle derivative, exhibits potent in vitro and in vivo antitu-<br />
moral activity which involves DNA damage and ataxia telan-<br />
giectasia-mutated nuclear protein kinase activation, Mol.<br />
Cancer Ther, 6, 193-202 (2007).<br />
BARKER, ERIC L. (b.1965) Associate Professor.<br />
B.S, 1988, St. Louis College of Pharmacy; Ph.D, 1993,<br />
Vanderbilt University. Research Associate, 1993-1995,<br />
Emory University; NIH Fellowship, 1995-1998, Vanderbilt<br />
University. Neuroscience; Pharmacology. Structurefunction<br />
of neurotransmitter transporters. TEL: (765)<br />
494-9940 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/barker.php<br />
Email: barkerel@purdue.edu<br />
Alejandra Gallardo-Godoy, Melissa I. Torres-Altoro, Kellie<br />
J. White, Eric L. Barker and David E. Nichols, 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate)<br />
iodide, MTS-<br />
MPP<br />
BORCH, RICHARD F. (b.1941) Lilly Distinguished<br />
Professor and Head. B.S, 1962, Stanford University;<br />
Ph.D, 1965, Columbia University; M.D, 1975, University<br />
of Minnesota. NIH Postdoctoral Fellowship, 1965-<br />
1966, Harvard University. Medicinal and/or Pharmaceu-<br />
tical Chemistry. Design, synthesis and mechanisms of<br />
action of antitumor agents. Phosphopeptidomimetic prodrugs.<br />
TEL: (765) 494-1403 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/borch.php<br />
Email: borch@purdue.edu<br />
Michelle K. Clark, Sarah A. Scott, Jonathan Wojtkowiak,<br />
Rosemarie Chirco, Patricia Mathieu, John J. Reiners, Jr.,<br />
Raymond R. Mattingly, Richard F. Borch and Richard A.<br />
Gibbs, Synthesis, Biochemical, and Cellular Evaluation of<br />
Farnesyl Monophosphate Prodrugs as Farnesyltransferase Inhibitors,<br />
J. Med. Chem, 50, 3274-3282 (2007).<br />
Weidong Wu, Jennifer Sigmond, Godefridus J. Peters and<br />
Richard F. Borch, Synthesis and Biological Activity of a<br />
Gemcitabine Phosphoramidate Prodrug, J. Med. Chem, 50,<br />
3743-3746 (2007).<br />
Irene G. Boutselis, Xiao Yu, Zhong-Yin Zhang and Richard<br />
F. Borch, Synthesis and Cell-Based Activity of a Potent<br />
and Selective Protein Tyrosine Phosphatase 1B Inhibitor Prodrug,<br />
J. Med. Chem, 50, 856-864 (2007).<br />
Jun Young Choi and Richard F. Borch, Highly Efficient<br />
Synthesis of Enantiomerically Enriched 2-Hydroxymethylaziridines<br />
by Enzymatic Desymmetrization, Org. Lett, 9,<br />
215-218 (2007).<br />
Meihua Luo, Sarah Delaplane, Aihua Jiang, April Reed,<br />
Ying He, Melissa Fishel, Rodney L. Nyland II, Richard F.<br />
Borch, Xiaoxi Qiao, Millie M. Georgiadis and Mark R. Kel-<br />
ley, Role of the Multifunctional DNA Repair and Redox Sig-<br />
naling Protein Ape1/Ref-1 in Cancer and Endothelial Cells:<br />
Small-Molecule Inhibition of the Redox Function of Ape1,<br />
Antioxid. Redox Signaling, 10, 1853-1868 (2008).<br />
Jonathan W. Wojtkowiak, Farid Fouad, Daniel T. LaLonde,<br />
Miriam D. Kleinman, Richard A. Gibbs, John J. Reiners,<br />
Jr., Richard F. Borch and Raymond R. Mattingly, Induc-<br />
tion of apoptosis in neurofibromatosis type 1 malignant pe-<br />
ripheral nerve sheath tumor cell lines by a combination of<br />
COLBY, DAVID A. (b.1977) Assistant Professor.<br />
Ph.D, 2006, University of California, Irvine. Postdoctoral<br />
Researcher, 2006-2008, The Scripps Research Institute.<br />
Medicinal and/or Pharmaceutical Chemistry; Organic<br />
Chemistry. Our research group blends the science<br />
of medicinal chemistry and synthetic organic chemistry<br />
through the use of natural product synthesis, the design<br />
of structurally-related analogues for structure-activity investigations,<br />
and the development of new synthetic<br />
methodologies. Specifically, we seek to use natural products<br />
as leads for drug discovery in drug-resistant cancer<br />
and infectious diseases. Also, we develop new synthetic<br />
methodologies to modify the structures of natural products.<br />
TEL: (765) 496-3962 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/?uid=dcolby<br />
Email: dcolby@purdue.edy<br />
Hayato Ishikawa, David A. Colby and Dale L. Boger, Direct<br />
Coupling of Catharanthine and Vindoline to Provide<br />
Vinblastine: Total Synthesis of (+)- and ent-(-)-Vinblastine,<br />
J. Am. Chem. Soc, 130, 420-421 (2008).<br />
CUSHMAN, MARK (b.1945) Professor. Pharm.D,<br />
1969, University of California, San Francisco; Ph.D,<br />
1973, University of California, San Francisco. NIH Postdoctoral<br />
Fellowship, 1973-1975, Massachusetts Institute<br />
of Technology (MIT); Senior Fulbright Scholar, 1983-<br />
1984, Munich Technical University. Medicinal and/or<br />
Pharmaceutical Chemistry; Organic Chemistry. Design<br />
and synthesis of potential antitumor, antiviral, and antibiotic<br />
agents. TEL: (765) 494-1465 FAX: (765) 494-6790<br />
Web: www.mcmp.purdue.edu/faculty/cushman.php<br />
Email: cushman@purdue.edu<br />
Johannes Kaiser, Boris Illarionov, Felix Rohdich, Wolfgang<br />
Eisenreich, Sabine Saller, Jan Van Den Brulle, Mark<br />
Cushman, Adelbert Bacher and Markus Fischer, A high-<br />
throughput screening platform for inhibitors of the riboflavin<br />
biosynthesis pathway, Anal. Biochem, 365, 52-61 (2007).<br />
Ha Young Kim, Richard J. Kuhn, Chinmay Patkar, Ranjit<br />
+, a novel scanning cysteine accessibility method<br />
(SCAM) reagent for monoamine transporter studies, Bioorg.<br />
Med. Chem, 15, 305-311 (2007).<br />
novel farnesyl transferase inhibitors and lovastatin, J. Pharmacol.<br />
Exp. Ther, 326, 1-11 (2008).<br />
Warrier and Mark Cushman, Synthesis of dioxane-based an-<br />
tiviral agents and evaluation of their biological activities as<br />
inhibitors of Sindbis virus replication, Bioorg. Med. Chem,<br />
Ekaterina A. Placzek, Yasuo Okamoto, Natsuo Ueda and<br />
Eric L. Barker, Mechanisms for recycling and biosynthesis of<br />
endogenous cannabinoids anandamide and 2-arachidonylgly-<br />
Rodney L Nyland II, Design and synthesis of novel quinones<br />
targeting the redox function of APE1/REF-1. (D)<br />
15, 2667-2679 (2007).<br />
Smitha Antony, Keli K. Agama, Ze-Hong Miao, Kazutaka<br />
Takagi, Mollie H. Wright, Ana I. Robles, Lyuba Varticovski,<br />
cerol, J. Neurochem, 107, 987-1000 (2008).<br />
Crystal C. Walline, David E. Nichols, F. Ivy Carroll and<br />
Eric L. Barker, Comparative molecular field analysis using<br />
selectivity fields reveals residues in the third transmembrane<br />
helix of the serotonin transporter associated with substrate<br />
and antagonist recognition, J. Pharmacol. Exp. Ther, 325,<br />
791-800 (2008).<br />
Matthew J. McFarland, Tamera K. Bardell, Marla L.<br />
Yates, Ekaterina A. Placzek and Eric L. Barker, RNA interference-mediated<br />
knockdown of dynamin 2 reduces endocannabinoid<br />
uptake into neuronal dCAD cells, Mol. Pharmacol,<br />
74, 101-108 (2008).<br />
BERGSTROM, DONALD E. (b.1943) Walther Professor.<br />
B.S, 1965, University of Washington, Seattle,<br />
WA; Ph.D, 1970, University of California, Berkeley.<br />
Postdoctoral Fellowship, 1970-1972, University of Illi-<br />
nois. Medicinal and/or Pharmaceutical Chemistry;<br />
Nanochemistry. Nucleic acid chemistry; biotechnology<br />
and nanotechnology of re-engineered nucleic acids; design<br />
and synthesis of nucleoside analogs. TEL: (765)<br />
494-6275 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/?uid=dbergstr<br />
Email: bergstrom@purdue.edu<br />
Roya R. Lahiji, Bridget D. Dolash, Donald E. Bergstrom<br />
and Ronald Reifenberger, Oligodeoxyribonucleotide association<br />
with single-walled carbon nanotubes studied by SPM,<br />
Small, 3, 1912-1920 (2007).<br />
Roman V. Rozhkov, V. Jo Davisson and Donald E. Bergstrom,<br />
Fluorogenic transformations based on formation of CC<br />
BOROWITZ, JOSEPH L. (b.1932) Professor. B.S,<br />
1955, Ohio State University; M.S, 1957, Purdue Univer-<br />
sity; Ph.D, 1959, Northwestern University. NSF Postdoc-<br />
toral Fellow, 1960-1962, Harvard Medical School. Cell<br />
Biology. trimethyltin neurotoxicology; mechanisms of<br />
cyanide neurotoxicity. TEL: (765) 494-1407 FAX: (765)<br />
494-1414<br />
Web: www.mcmp.purdue.edu/faculty/borowitz.php<br />
Email: borowitz@pharmacy.purdue.edu<br />
Heather B. Leavesley, Li Li, Krishnan Prabhakaran, Joseph<br />
L. Borowitz and Gary E. Isom, Interaction of Cyanide and<br />
Nitric Oxide with Cytochrome c Oxidase: Implications for<br />
Acute Cyanide Toxicity, Toxicol. Sci, 101, 101-111 (2008).<br />
Joseph L. Borowitz and Gary E. Isom, Nicotine and Type 2<br />
Diabetes, Toxicol. Sci, 103, 225-227 (2008).<br />
CHANG, CHING-JER (b.1942) Professor. B.S, 1965,<br />
National Taiwan Cheng Kung University; Ph.D, 1972,<br />
Indiana University. Postdoctoral Fellowship, 1972, Pur-<br />
due University. Medicinal and/or Pharmaceutical Chemistry;<br />
Natural Products Chemistry. Discovery and design<br />
of oncogene signal transduction inhibitors; isolation,<br />
structure elucidation and synthesis of bioactive natural<br />
products; natural chemopreventive agents; bioorganic<br />
chemistry of cyclodextrins; enzymatic synthesis and biotransformation<br />
of bioactive compounds. TEL: (765) 494-<br />
1373 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/chang.php<br />
Muthukaman Nagarajan, Andrew Morrell, Mark Cushman<br />
and Yves Pommier, Novel Indenoisoquinolines NSC 725776<br />
and NSC 724998 Produce Persistent Topoisomerase I Cleavage<br />
Complexes and Overcome Multidrug Resistance, Cancer<br />
Res, 67, 10397-10405 (2007).<br />
Smitha Antony, Keli K. Agama, Ze-Hong Miao, Kazutaka<br />
Takagi, Mollie H. Wright, Ana I. Robles, Lyuba Varticovski,<br />
Muthukaman Nagarajan, Andrew Morrell, Mark Cushman<br />
and Yves Pommier, Novel indenoisoquinolines NSC 725776<br />
and NSC 724998 produce persistent topoisomerase I cleavage<br />
complexes and overcome multidrug resistance. [Erratum<br />
to document cited in CA148:092441], Cancer Res, 67, 12034<br />
(2007).<br />
Chan Yong Lee, Boris Illarionov, Young-Eun Woo, Kristina<br />
Kemter, Ryu-Ryun Kim, Sabine Eberhardt, Mark Cush-<br />
man, Wolfgang Eisenreich, Markus Fischer and Adelbert<br />
Bacher, Ligand binding properties of the N-terminal domain<br />
of riboflavin synthase from Escherichia coli, J. Biochem.<br />
Mol. Biol, 40, 239-246 (2007).<br />
Ekaterina Morgunova, Sabine Saller, Ilka Haase, Mark<br />
Cushman, Adelbert Bacher, Markus Fischer and Rudolf Ladenstein,<br />
Lumazine Synthase from Candida albicans as an<br />
Anti-fungal Target Enzyme: Structural and Biochemical Ba-<br />
sis for Drug Design, J. Biol. Chem, 282, 17231-17241<br />
(2007).<br />
Andrew Morrell, Michael S. Placzek, Jamin D. Steffen,<br />
Smitha Antony, Keli Agama, Yves Pommier and Mark Cush-<br />
man, Investigation of the Lactam Side Chain Length Neces-<br />
sary for Optimal Indenoisoquinoline Topoisomerase I Inhibition<br />
and Cytotoxicity in Human Cancer Cell Cultures, J.<br />
Med. Chem, 50, 2040-2048 (2007).
2 <strong>PURDUE</strong><br />
Arup Maiti, Muriel Cuendet, Vicki L. Croy, Denise C. En- mel, William E. Fogler, Gregory E. Agoston, Phillip E. Fan- tive Syk Tyrosine Kinase for the Study of Signaling Dynamdringer,<br />
John M. Pezzuto and Mark Cushman, Synthesis and wick and Mark Cushman, Stereoselective Synthesis of 3,3- ics from the B Cell Antigen Receptor, J. Biol. Chem, 282,<br />
Biological Evaluation of (±)-Abyssinone II and Its Ana- Diarylacrylonitriles as Tubulin Polymerization Inhibitors, J. 33760-33768 (2007).<br />
logues as Aromatase Inhibitors for Chemoprevention of Org. Chem, 73, 4241-4244 (2008).<br />
Fei Zhou, Jacob Galan, Robert L. Geahlen and W. Andy<br />
Breast Cancer, J. Med. Chem, 50, 2799-2806 (2007).<br />
Yunlong Song and Mark Cushman, The Binding Orienta- Tao, A Novel Quantitative Proteomics Strategy To Study<br />
Takeshi Sakamoto, Matthew D. Cullen, Tracy L. Hartman, tion of a Norindenoisoquinoline in the Topoisomerase I- Phosphorylation-Dependent Peptide-Protein Interactions, J.<br />
Karen M. Watson, Robert W. Buckheit, Christophe Pannec- DNA Cleavage Complex Is Primarily Governed by - Proteome Res, 6, 133-140 (2007).<br />
ouque, Erik De Clercq and Mark Cushman, Synthesis and Stacking Interactions, J. Phys. Chem. B, 112, 9484-9489 Jun Wang, Ning Bao, Leela L. Paris, Hsiang-Yu Wang,<br />
Anti-HIV Activity of New Metabolically Stable Alkenyldia- (2008). Robert L. Geahlen and Chang Lu, Detection of Kinase Transrylmethane<br />
Non-Nucleoside Reverse Transcriptase Inhibitors Matthew Cullen, Deborah Miles, Arlene Rothwell, Connie location Using Microfluidic Electroporative Flow Cytometry,<br />
Incorporating N-Methoxy Imidoyl Halide and 1,2,4-Oxadia- Bonham, Karl V. Wood and Mark Cushman, Hydrolysis of Anal. Chem. (Washington, DC, U. S.), 80, 1087-1093 (2008).<br />
zole Systems, J. Med. Chem, 50, 3314-3321 (2007).<br />
thioesters in an ion trap, Rapid Commun. Mass Spectrom, 22, Jun Wang, Ning Bao, Leela L. Paris, Robert L. Geahlen<br />
Arup Maiti, Muriel Cuendet, Tamara Kondratyuk, Vicki L. 1094-1098 (2008). and Chang Lu, Total Internal Reflection Fluorescence Flow<br />
Croy, John M. Pezzuto and Mark Cushman, Synthesis and<br />
Cytometry, Anal. Chem. (Washington, DC, U. S.), 80, 9840-<br />
Cancer Chemopreventive Activity of Zapotin, a Natural<br />
Product from Casimiroa edulis, J. Med. Chem, 50, 350-355<br />
(2007).<br />
Andrew Morrell, Michael Placzek, Seth Parmley, Brian<br />
Grella, Smitha Antony, Yves Pommier and Mark Cushman,<br />
Optimization of the Indenone Ring of Indenoisoquinoline<br />
Topoisomerase I Inhibitors, J. Med. Chem, 50, 4388-4404<br />
(2007).<br />
Andrew Morrell, Michael Placzek, Seth Parmley, Smitha<br />
Antony, Thomas S. Dexheimer, Yves Pommier and Mark<br />
Cushman, Nitrated Indenoisoquinolines as Topoisomerase I<br />
Inhibitors: A Systematic Study and Optimization, J. Med.<br />
Chem, 50, 4419-4430 (2007).<br />
Matthew D. Cullen, Bo-Liang Deng, Tracy L. Hartman,<br />
Karen M. Watson, Robert W. Buckheit, Jr., Christophe Pannecouque,<br />
Erik De Clercq and Mark Cushman, Synthesis and<br />
Biological Evaluation of Alkenyldiarylmethane HIV-1 Non-<br />
Nucleoside Reverse Transcriptase Inhibitors That Possess Increased<br />
Hydrolytic Stability, J. Med. Chem, 50, 4854-4867<br />
Juma Hoshino, Design and synthesis of analogs and metabolites<br />
of resveratrol as chemopreventive agents. (M)<br />
Katherine E. Peterson, Investigation of the stereochemical<br />
effects of the indenoisoquinoline side chain on topoisomerase<br />
i inhibition. (M)<br />
Yanlei Zhang, Design, synthesis and bioevaluation of lumazine<br />
synthase inhibitors. (M)<br />
Andrew Edward O’Dell Morrell, Development of topoisomerase<br />
I inhibitors as anticancer agents. (D)<br />
Matthew David Cullen, Investigations on alkenyldiarylmethase<br />
HIV-1 reverse transcriptase inhibitors: Mechanism of<br />
action, synthesis, and metabolic evaluation of hydrolytically<br />
stable analogues. (D)<br />
DAVISSON, VINCENT JO (b.1955) Professor. B.A,<br />
1978, Wittenberg University; M.S, 1983, Indiana Uni-<br />
versity; Ph.D, 1988, University of Utah. Postdoctoral<br />
Fellowship, 1987-1989, University of California, San<br />
Francisco, Department of Biochemistry and Biophysics.<br />
9844 (2008).<br />
Thibaud Lebouvier, Timothy M. E. Scales, Diane P. Hanger,<br />
Robert L. Geahlen, Bernard Lardeux, C. Hugh Reynolds,<br />
Brian H. Anderton and Pascal Derkinderen, The microtubuleassociated<br />
protein tau is phosphorylated by Syk, Biochim.<br />
Biophys. Acta, Mol. Cell Res, 1783, 188-192 (2008).<br />
Manqing Li, Su Sien Ong, Bartek Rajwa, Vivian T. Thieu,<br />
Robert L. Geahlen and Marietta L. Harrison, The SH3 domain<br />
of Lck modulates T-cell receptor-dependent activation<br />
of extracellular signal-regulated kinase through activation of<br />
Raf-1, Mol. Cell. Biol, 28, 630-641 (2008).<br />
Yajie Zhang, Hyunju Oh, Robert A. Burton, John W.<br />
Burgner, Robert L. Geahlen and Carol Beth Post, Tyr130<br />
phosphorylation triggers Syk release from antigen receptor<br />
by long-distance conformational uncoupling, Proc. Natl.<br />
Acad. Sci. U. S. A, 105, 11760-11765 (2008).<br />
GHOSH, ARUN K.—See Chemistry Section, Purdue<br />
University, Department of Chemistry.<br />
(2007).<br />
Allison B. Edsall, Gregory E. Agoston, Anthony M. Treston,<br />
Stacy M. Plum, Robert H. McClanahan, Tian-Sheng<br />
Lu, Wei Song and Mark Cushman, Synthesis and in Vivo<br />
Antitumor Evaluation of 2-Methoxyestradiol 3-Phosphate,<br />
17-Phosphate, and 3,17-Diphosphate, J. Med. Chem, 50,<br />
6700-6705 (2007).<br />
Yanlei Zhang, Boris Illarionov, Adelbert Bacher, Markus<br />
Fischer, Gunda I. Georg, Qi-Zhuang Ye, David Vander<br />
Velde, Phillip E. Fanwick, Yunlong Song and Mark Cushman,<br />
A Novel Lumazine Synthase Inhibitor Derived from<br />
Oxidation of 1,3,6,8-Tetrahydroxy-2,7-naphthyridine to a<br />
Tetraazaperylenehexaone Derivative, J. Org. Chem, 72,<br />
2769-2776 (2007).<br />
Arindam Talukdar, Boris Illarionov, Adelbert Bacher,<br />
Markus Fischer and Mark Cushman, Synthesis and Enzyme<br />
Inhibitory Activity of the S-Nucleoside Analogue of the Ribitylaminopyrimidine<br />
Substrate of Lumazine Synthase and<br />
Product of Riboflavin Synthase, J. Org. Chem, 72, 7167-<br />
7175 (2007).<br />
Yanlei Zhang, Guangyi Jin, Boris Illarionov, Adelbert<br />
Bacher, Markus Fischer and Mark Cushman, A New Series<br />
of 3-Alkyl Phosphate Derivatives of 4,5,6,7-Tetrahydro-1-Dribityl-1H-pyrazolo[3,4-d]pyrimidinedione<br />
as Inhibitors of<br />
Lumazine Synthase: Design, Synthesis, and Evaluation, J.<br />
Org. Chem, 72, 7176-7184 (2007).<br />
Muriel Cuendet, Carol P. Oteham, Arup Maiti, Bruce A.<br />
Craig, Mark Cushman, Richard C. Moon and John M. Pezzuto,<br />
Zapotin prevents mouse skin tumorigenesis during the<br />
stages of initiation and promotion, Anticancer Research, 28,<br />
3705-3709 (2008).<br />
Tsyr-Yan Yu, Robert D. O’Connor, Astrid C. Sivertsen,<br />
Colby Chiauzzi, Barbara Poliks, Markus Fischer, Adelbert<br />
Bacher, Ilka Haase, Mark Cushman and Jacob Schaefer,<br />
15N{31P} REDOR NMR studies of the binding of phosphonate<br />
reaction intermediate analogues to saccharomyces cerevisiae<br />
lumazine synthase, Biochemistry, 47, 13942–13951<br />
(2008).<br />
Matthew D. Cullen, York-Fong Cheung, Miles D. Houslay,<br />
Tracy L. Hartman, Karen M. Watson, Robert W. Buckheit,<br />
Christophe Pannecouque, Erik De Clercq and Mark<br />
Cushman, Investigation of the alkenyldiarylmethane non-nucleoside<br />
reverse transcriptase inhibitors as potential cAMP<br />
phosphodiesterase-4B2 inhibitors, Bioorg. Med. Chem. Lett,<br />
18, 1530-1533 (2008).<br />
Matthew D. Cullen, Taradas Sarkar, Ernest Hamel, Tracy<br />
L. Hartman, Karen M. Watson, Robert W. Buckheit, Christophe<br />
Pannecouque, Erik De Clercq and Mark Cushman, Inhibition<br />
of tubulin polymerization by select alkenyldiarylmethanes,<br />
Bioorg. Med. Chem. Lett, 18, 469-473 (2008).<br />
Maris A. Cinelli, Andrew Morrell, Thomas S. Dexheimer,<br />
Evan S. Scher, Yves Pommier and Mark Cushman, Design,<br />
Synthesis, and Biological Evaluation of 14-Substituted Aromathecins<br />
as Topoisomerase I Inhibitors, J. Med. Chem, 51,<br />
4609-4619 (2008).<br />
Ze Li, Mansoora Khaliq, Zhigang Zhou, Carol Beth Post,<br />
Richard J. Kuhn and Mark Cushman, Design, Synthesis, and<br />
Biological Evaluation of Antiviral Agents Targeting Flavivirus<br />
Envelope Proteins, J. Med. Chem, 51, 4660-4671 (2008).<br />
Yanlei Zhang, Boris Illarionov, Ekaterina Morgunova,<br />
Guangyi Jin, Adelbert Bacher, Markus Fischer, Rudolf Ladenstein<br />
and Mark Cushman, A New Series of N-[2,4-Dioxo-<br />
6-D-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic<br />
Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin<br />
Synthase: Design, Synthesis, Biochemical Evaluation,<br />
Crystallography, and Mechanistic Implications, J. Org.<br />
Chem, 73, 2715-2724 (2008).<br />
Zhenglai Fang, Yunlong Song, Taradas Sarkar, Ernest Ha-<br />
Chemical Biology; Medicinal and/or Pharmaceutical<br />
Chemistry. Medicinal Chemistry and cellular pharmacology<br />
of natural product drugs. Cell based and biomolecular<br />
assay tools for drug discovery and development in<br />
cancer and neurodegenerative diseases. Targeting of<br />
small molecules to disease-specific receptors; analysis of<br />
small molecules agonists and antagonists of regulatory<br />
protein interactions. TEL: (765) 494-5238 FAX: (765)<br />
494-1414<br />
Web: www.mcmp.purdue.edu/faculty/davisson.php<br />
Email: davisson@purdue.edu<br />
R. E. Amaro, R. S. Myers, V. J. Davisson and Z. A. Luthey-Schulten,<br />
A network of conserved interactions regulates<br />
the allosteric signal in a glutamine amidotransferase, Biochemistry,<br />
46, 2156-2173 (2007).<br />
D. Schweitzer, J. Zhu, G. Jarori, J. J. Kane, J. Tanaka, T.<br />
Higa, V. J. Davisson and P. Helquist, Synthesis of carbamate<br />
derivatives of iejimalides. Retention of normal antiproliferative<br />
activity and localization of binding in cancer cells,<br />
Bioorganic and Medicinal Chemistry, 15, 3208-3216 (2007).<br />
R. Rozhkov, V. J. Davisson and D. E. Bergstrom, Fluorogenic<br />
tranformations based on formation of C-C bonds cata-<br />
lyzed by palladium: An efficient approach for high through-<br />
put optimizations and kinetic studies, Advanced Synthesis<br />
and Catalysis, 350, 71-75 (2008).<br />
S. K. Deb, B. Davis, D. Ben-Amotz and V. J. Davisson,<br />
Accurate concentration measurements using surface-enhanced<br />
raman and deuterium exchanged dye pairs, Applied<br />
Spectroscopy, 62, 1001-1007 (2008).<br />
G. M. Knudsen, B. M. Davis, S. K. Deb, Y. Loethen, R.<br />
Gudihal, P. Perera, D. Ben-Amotz and V. J. Davisson, Quantification<br />
of isotope encoded proteins in 2-D gels using surface<br />
enhanced resonance raman, Bioconjugate Chem, 19,<br />
2212-2220 (2008).<br />
S. M. Firestine, W. Wu, H. Youn and V. J. Davisson, Interrogating<br />
the mechanism of a tight binding inhibitor of AIR<br />
carboxylase, Bioorganic and Medicinal Chemistry, 17, 794-<br />
803 (2008).<br />
F. Liu, J. Hindupur, J. L. Nguyen, K. J. Ruf, J. Zhu, J. L.<br />
Schieler, C. C. Bonham, K. V. Wood, V. J. Davisson and J.-<br />
L. Rochet, Methionine sulfoxide reductase A protects dopaminergic<br />
cells from Parkinson’s disease-related insults, Free<br />
Radical Biology & Medicine, 45, 242-255 (2008).<br />
S. K. Deb, B. Davis, G. M. Knudsen, R. Gudihal, D. Ben-<br />
Amotz and V. J. Davisson, Detection and relative quantification<br />
of proteins by surface enhanced raman using isotopic labels,<br />
J. Am. Chem. Soc, 30, 9624-9625 (2008).<br />
Y. L. Loethen, G. M. Knudsen, B. Davis, R. Gudihal, V. J.<br />
Davisson and D. Ben-Amotz, Protein quantitation in 2-D gels<br />
using fluorescence with water raman as an internal standard,<br />
J. Proteome Res, 7, 1341-1345 (2008).<br />
GEAHLEN, ROBERT L. (b.1953) Professor. B.S,<br />
1975, University of Southern Colorado; Ph.D, 1978,<br />
University of Wyoming. Postdoctoral Fellowship, 1978,<br />
University of Washington; NIH Fellowship, 1978, University<br />
of Washington; Juvenile Diabetes Foundation<br />
Fellowship, 1980, University of Washington. Biochemistry;<br />
Immunology. Protein-tyrosine kinases and lymphocyte<br />
activation; tyrosine kinases and breast cancer; protein<br />
acylation; antitumor agents. TEL: (765) 494-1457<br />
FAX: (765) 494-9193<br />
Web: www.mcmp.purdue.edu/faculty/geahlen.php<br />
Email: geahlen@purdue.edu<br />
Hyunju Oh, Elif Ozkirimli, Kavita Shah, Marietta L. Harrison<br />
and Robert L. Geahlen, Generation of an Analog-sensi-<br />
GIBBS, RICHARD A. (b.1961) Professor. B.S, 1983,<br />
Johns Hopkins University; Ph.D, 1988, University of California,<br />
Riverside. NSF Fellowship, 1988-1991, Penn<br />
State University. Chemical Biology; Medicinal and/or<br />
Pharmaceutical Chemistry. Chemical probes of protein<br />
prenylation; mechanistic studies of the enzyme proteinfarnesyl<br />
transferase; inhibitors of the enzyme isoprenylcysteine<br />
methyltransferase; novel methods for the synthesis<br />
of isoprenoid analogs. TEL: (765) 494-1456 FAX:<br />
(765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/gibbs.php<br />
Email: rgibbs@purdue.edu<br />
Amanda J. Krzysiak, Diwan S. Rawat, Sarah A. Scott, June<br />
E. Pais, Misty Handley, Marietta L. Harrison, Carol A.<br />
Fierke and Richard A. Gibbs, Combinatorial Modulation of<br />
Protein Prenylation, ACS Chem. Biol, 2, 385-389 (2007).<br />
Amanda J. Krzysiak, Sarah A. Scott, Katherine A. Hicks,<br />
Carol A. Fierke and Richard A. Gibbs, Evaluation of protein<br />
farnesyltransferase substrate specificity using synthetic peptide<br />
libraries, Bioorg. Med. Chem. Lett, 17, 5548-5551<br />
(2007).<br />
Michelle K. Clark, Sarah A. Scott, Jonathan Wojtkowiak,<br />
Rosemarie Chirco, Patricia Mathieu, John J. Reiners, Jr.,<br />
Raymond R. Mattingly, Richard F. Borch and Richard A.<br />
Gibbs, Synthesis, Biochemical, and Cellular Evaluation of<br />
Farnesyl Monophosphate Prodrugs as Farnesyltransferase In-<br />
hibitors, J. Med. Chem, 50, 3274-3282 (2007).<br />
Linda Henneman, Arno G. van Cruchten, Simone W.<br />
Denis, Michael J. Amolins, Andrew T. Placzek, Richard A.<br />
Gibbs, Willem Kulik and Hans R. Waterham, Isoprenoid de-<br />
tection by tandem mass spectrometry, Analytical Biochemis-<br />
try, 383, 18-24 (2008).<br />
Michelle Maynor, Sarah A. Scott, Emily L. Rickert and<br />
Richard A. Gibbs, Synthesis and evaluation of 3- and 7-sub-<br />
stituted geranylgeranyl pyrophosphate analogs, Bioorg. Med.<br />
Chem. Lett, 18, 1889-1892 (2008).<br />
Diwan S. Rawat, Amanda J. Krzysiak and Richard A.<br />
Gibbs, Synthesis and Biochemical Evaluation of 3,7-Disubstituted<br />
Farnesyl Diphosphate Analogues, J. Org. Chem, 73,<br />
1881-1887 (2008).<br />
Jonathan W. Wojtkowiak, Farid Fouad, Daniel T. LaLonde,<br />
Miriam D. Kleinman, Richard A. Gibbs, John J. Reiners,<br />
Jr., Richard F. Borch and Raymond R. Mattingly, Induction<br />
of apoptosis in neurofibromatosis type 1 malignant pe-<br />
ripheral nerve sheath tumor cell lines by a combination of<br />
novel farnesyl transferase inhibitors and lovastatin, J. Pharmacol.<br />
Exp. Ther, 326, 1-11 (2008).<br />
Amanda J. Krzysiak, Modulating Farnesyltransferase substrate<br />
specificity: Tools for altering protein function in vivo.<br />
(D)<br />
James L. Donelson, A new solid-phase route to prenylcysteine<br />
derivatives: Development of isoprenylcysteine carboxyl<br />
methyltransferase inhibitors. (D)<br />
HARRISON, MARIETTA L. (b.1948) Professor.<br />
B.A, 1970, University of New Hampshire; Ph.D, 1980,<br />
University of Wyoming. Cancer Research Institute Fellowship,<br />
1980, Fred Hutchinson Cancer Research Cen-<br />
ter; NIH Fellowship, 1981, Fred Hutchinson Cancer Research<br />
Center and Purdue University. Biochemistry; Immunology.<br />
Our research involves investigating the role of<br />
cellular protein-tyrosine kinases in cell division and dif-<br />
ferentiation. TEL: (765) 494-1442 FAX: (765) 494-9193<br />
Web: www.mcmp.purdue.edu/faculty/harrison.php
<strong>PURDUE</strong> 3<br />
Email: harrisom@purdue.edu<br />
Amanda J. Krzysiak, Diwan S. Rawat, Sarah A. Scott, June<br />
E. Pais, Misty Handley, Marietta L. Harrison, Carol A.<br />
Fierke and Richard A. Gibbs, Combinatorial Modulation of<br />
Protein Prenylation, ACS Chem. Biol, 2, 385-389 (2007).<br />
Maia M. Donahue, Wei Zhang, Marietta L. Harrison, Jianghai<br />
Hu and Ann E. Rundell, Employing optimization and<br />
sensitivity analyses tools to generate and analyze mathematical<br />
models of T cell signaling events, AIP Conf. Proc, 953,<br />
43-63 (2007).<br />
Hyunju Oh, Elif Ozkirimli, Kavita Shah, Marietta L. Harrison<br />
and Robert L. Geahlen, Generation of an Analog-sensitive<br />
Syk Tyrosine Kinase for the Study of Signaling Dynamics<br />
from the B Cell Antigen Receptor, J. Biol. Chem, 282,<br />
33760-33768 (2007).<br />
Manqing Li, Su Sien Ong, Bartek Rajwa, Vivian T. Thieu,<br />
Robert L. Geahlen and Marietta L. Harrison, The SH3 domain<br />
of Lck modulates T-cell receptor-dependent activation<br />
of extracellular signal-regulated kinase through activation of<br />
Raf-1, Mol. Cell. Biol, 28, 630-641 (2008).<br />
A. T. Krans, Dephosphorylation of Phosphoserine 59 in the<br />
Protein Tyrosine Kinase, Lck. (M)<br />
M. B. Baker, The Effect of Serine 59 Phosphorylation on<br />
the Conformation of the Protein Binding Domains of the Pro-<br />
tein Tyrosine Kinase Lck. (D)<br />
M. D. Handley, Anchors away: An alternative role for farnesylation<br />
of Ras. (D)<br />
M. L. Vázquez, Biological Consequences of the Phosphorylation<br />
of Serine 59 on the Tyrosine Kinase Lck. (D)<br />
HAZBUN, TONY R. Assistant Professor. B.Sc, 1989,<br />
University of Queensland; Ph.D, 1997, University of Notre<br />
Dame. Research Associate, 1998-2005, Howard<br />
Hughes Medical Institute. Bioinformatics; Genetics.<br />
Functional genomics, Systems Biology, Mitosis, Proteinprotein<br />
interactions, Two-hybrid, Chemical genetics, Aurora<br />
kinase, Bub1 kinase, genetic interactions. TEL:<br />
(765) 496-8228 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/?uid=hazbun<br />
Email: thazbun@purdue.edu<br />
J. Wong, Y. Nakajima, S. Westermann, C. Shang C. Goodner,<br />
P. Houshmand, C. Chan, S. Fields, D. G. Drubin, G.<br />
Barnes and T. Hazbun, A protein interaction map of the mitotic<br />
spindle, Mol Biol Cell, 18, 3800-09 (2007).<br />
HOCKERMAN, GREGORY H. (b.1961) Associate<br />
Professor. B.S, 1983, Olivet Nazarene College; Ph.D,<br />
1991, University of Wisconsin. NIH Fellowship, 1991-<br />
1997, University of Washington. Pharmacology; Physi-<br />
ology. Molecular determinants of dihydropyridine, phenylalkylamine<br />
and benzothiazepine block of L-type cal-<br />
cium channels; synthesis of novel calcium channel<br />
blockers as research tools, L-type calcium channel mod-<br />
ulation of insulin secretion. TEL: (765) 496-3874 FAX:<br />
(765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/hockerman.php<br />
Email: gregh@pharmacy.purdue.edu<br />
Kenneth B. Walsh, Jining Zhang, John W. Fuseler, Nathan<br />
Hilliard and Gregory H. Hockerman, Adenoviral-mediated<br />
expression of dihydropyridine-insensitive L-type calcium<br />
channels in cardiac ventricular myocytes and fibroblasts,<br />
Eur. J. Pharmacol, 565, 7-16 (2007).<br />
X. Wang, R. Xu, G. Abernathey, J. Taylor, M. Alzghoul,<br />
K. Hannon, G. H. Hockerman and A Pond, Kv11.1 channel<br />
subunit composition varies developmentally in mouse cardiac<br />
muscle, Developmetal Dynamics, 237, 2430-2437 (2008).<br />
Pierre-Alexandre Vidi, Benjamin R. Chemel, Chang-Deng<br />
Hu and Val J. Watts, Ligand-dependent oligomerization of<br />
dopamine D2 and adenosine A2A receptors in living neuronal<br />
cells, Mol. Pharmacol, 74, 544-551 (2008).<br />
Y. John Shyu, Christopher D. Suarez and Chang-Deng Hu,<br />
Visualization of ternary complexes in living cells by using a<br />
BiFC-based FRET assay, Nat. Protoc, 3, 1693-1702 (2008).<br />
Y. John Shyu, Susan M. Hiatt, Holli M. Duren, Ronald E.<br />
Ellis, Tom K. Kerppola and Chang-Deng Hu, Visualization<br />
of protein interactions in living Caenorhabditis elegans using<br />
bimolecular fluorescence complementation analysis, Nat.<br />
Protoc, 3, 588-596 (2008).<br />
Y. John Shyu, Christopher D. Suarez and Chang-Deng Hu,<br />
Visualization of AP-1-NF-B ternary complexes in living<br />
cells by using a BiFC-based FRET, Proc. Natl. Acad. Sci. U.<br />
S. A, 105, 151-156 (2008).<br />
Y. John Shyu and Chang-Deng Hu, Fluorescence complementation:<br />
An emerging tool for biological research, Trends<br />
Biotechnol, 26, 622-630 (2008).<br />
Susan M. Hiatt, Understanding AP-1 dimerization in vivo:<br />
Genetic and BiFC analysis of C. elegans FOS-1 and JUN-1<br />
in regulation of ovulation. (D)<br />
Yeong-Shiun John Shyu, Understanding the role of ATF-1<br />
homodimers in Caenorhabditis elegans development using a<br />
novel bimolecular fluorescence complementation-based<br />
dominant dimeric repressor assay. (D)<br />
ISOM, GARY E. (b.1946) Professor. B.S, 1969, Idaho<br />
State University; Ph.D, 1973, Washington State University.<br />
Neuroscience; Toxicology. Biochemical mechanisms<br />
of neurotoxicity; excitotoxic neurotransmitters in<br />
xenobiotic neurotoxicity. TEL: (765) 494-5905 FAX:<br />
(765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/isom.php<br />
Email: geisom@purdue.edu<br />
Heather B. Leavesley, Li Li, Krishnan Prabhakaran, Joseph<br />
L. Borowitz and Gary E. Isom, Interaction of Cyanide and<br />
Nitric Oxide with Cytochrome c Oxidase: Implications for<br />
Acute Cyanide Toxicity, Toxicol. Sci, 101, 101-111 (2008).<br />
Joseph L. Borowitz and Gary E. Isom, Nicotine and Type 2<br />
Diabetes, Toxicol. Sci, 103, 225-227 (2008).<br />
LACOUNT, DOUGLAS J. (b.1970) Assistant professor.<br />
B.S, 1992, University of Wisconsin-Madison; Ph.D,<br />
1998, University of Wisconsin-Madison. post-doc, 1998-<br />
1002, University of Iowa; post-doc, 2001-2005, University<br />
of Washington. Molecular Biology; Virology. My<br />
current research focuses on interactions between host<br />
cells and obligate intracellular parasites. We seek to<br />
identify physical interactions between host cell proteins<br />
and viral or malaria proteins in order to better understand<br />
how intracellular parasites manipulate their hosts and to<br />
discover host cell proteins that are required for growth of<br />
multiple pathogens. TEL: (765) 496-7835 FAX: (765)<br />
494-1414<br />
Web: www.mcmp.purdue.edu/faculty/?uid=dlacount<br />
Email: dlacount@pharmacy.purdue.edu<br />
M. Vignali A. McKinlay, D. J. LaCount, R. Chettier, R.<br />
Bell, S. Sahasrabudhe, R. E. Hughes and S. Fields, Interaction<br />
of an atypical Plasmodium falciparum ETRAMP with<br />
human apolipoproteins, Malar J, 20, 211 (2008).<br />
LILL, MARKUS A. (b.1974) Assistant Professor.<br />
M.Sc, 1998, University of Erlangen-Nuernberg, Germany;<br />
Ph.D, 2002, Max Planck Institute for Biophysics,<br />
Germany. Research Associate, 2002-2006, Biographics<br />
Louisiana State University; Ph.D, 1968, University of<br />
California, Berkeley. Postdoctoral Fellowship, 1968-<br />
1970, University of California, Berkeley, Department of<br />
Biochemistry. Bioorganic Chemistry; Chemistry Education.<br />
Chemical mechanisms, bioorganic chemistry,<br />
chemical education with emphasis on organic chemistry.<br />
TEL: (765) 494-1462 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/loudon.php<br />
Email: loudonm@purdue.edu<br />
Animesh Aditya, David E. Nichols and G. Marc Loudon,<br />
Borohydride reduction of estrone. Demonstration of diaster-<br />
eoselectivity in the undergraduate organic chemistry labora-<br />
tory, Journal of Chemical Education, 85, 1585-1587 (2008).<br />
MORRÉ, D. JAMES (b.1935) Dow Distinguished<br />
Professor. B.S, 1957, University of Missouri; M.S, 1959,<br />
Purdue University; Ph.D, 1963, Caltech; D.h.c, 1985,<br />
University of Geneva; D.h.c, 2000, Universite Victor<br />
Segalen, Bordeaux, France. Biochemistry. Researches<br />
the biochemistry of cell growth and dynamics of intracellular<br />
membranes and is familiar with a wide range of in-<br />
vestigative approaches to elucidation of structure-function<br />
correlations in cell biology, subcellular biochemis-<br />
try, and medicinal chemistry. Recently described a novel<br />
universal cancer marker, designated tNOX, a protein lo-<br />
cated at the cell surface and having protein disulfide-thiol<br />
interchange/NADH oxidase activity that is growth re-<br />
lated and inhibited by anticancer drugs. TEL: (765) 494-<br />
1388 FAX: (765) 494-4007<br />
Web: www.mcmp.purdue.edu/faculty/morre.php<br />
Email: morred@purdue.edu<br />
Xiaoyu Tang, Zengsui Tian, Pin-Ju Chueh, Ssuhen Chen,<br />
Dorothy M. Morre and D. James Morre, Alternative Splicing<br />
as the Basis for Specific Localization of tNOX, a Unique Hy-<br />
droquinone (NADH) Oxidase, to the Cancer Cell Surface,<br />
Biochemistry, 46, 12337-12346 (2007).<br />
Raymond Cooper, Talash A. Likimani, D. James Morre<br />
and Dorothy M. Morre, Catechins and caffeine in tea: A review<br />
of health risks and benefits, Caffeine Act. Theory, 351-<br />
364 (2007).<br />
D. James Morre and Hilton H. Mollenhauer, Microscopic<br />
morphology and the origins of the membrane maturation<br />
model of Golgi apparatus function, Int. Rev. Cytol, 262, 191-<br />
218 (2007).<br />
Kader Yagiz, Lion-Ying Wu, Charles P. Kuntz, D. James<br />
Morre and Dorothy M. Morre, Mouse embryonic fibroblast<br />
cells from transgenic mice overexpressing tNOX exhibit an<br />
altered growth and drug response phenotype, J. Cell. Biochem,<br />
101, 295-306 (2007).<br />
D. James Morre, Steve Heald, Jason Coleman, John Orczyk,<br />
Ziying Jiang and Dorothy M. Morre, Structural observa-<br />
tions of time dependent oscillatory behavior of copper (II)<br />
chloride solutions measured via extended X-ray absorption<br />
fine structure, J. Inorg. Biochem, 101, 715-726 (2007).<br />
D. James Morre, P.-J. Chueh, Kader Yagiz, Andrew Balicki,<br />
Chinpal Kim and Dorothy M. Morre, ECTO-NOX target<br />
for the anticancer isoflavene phenoxodiol, Oncol. Res,<br />
16, 299-312 (2007).<br />
Connie M. Weaver, Stephen Barnes, J. Michael Wyss, Hel-<br />
en Kim, Dorothy M. Morre, D. James Morre, James E. Si-<br />
mon, Mary Ann Lila, Elsa M. Janle and Mario G. Ferruzzi,<br />
Botanicals for age-related diseases: from field to practice,<br />
Am. J. Clin. Nutr, 87, 493S-497S (2008).<br />
D. James Morre, Sara Dick, Elena Bosneaga, Andrew Bal-<br />
icki, Lian-Ying Wu, Nicole McClain and Dorothy M. Morre,<br />
tNOX (ENOX1) target for chemosensitization—low-dose re-<br />
Sarah Melissa P. Jacobo, Dichotomy of Cav1.2 and Cav1.3<br />
L-type Ca2+ channel function and modulation in GLP-1mediated<br />
insulin exocytosis and ERK1/2 activation in pancreatic<br />
beta cells. (D)<br />
HU, CHANG-DENG (b.1961) Associate Professor.<br />
M.D, 1984, Bengbu Medical College, China; M.S, 1987,<br />
Tongji Medical University, China; Ph.D, 1997, Kobe<br />
University School of Medicine, Japan. Research Investigator/Specialist,<br />
2000-2003, Univ. of Michigan School<br />
of Medicine. Cell Biology; Developmental Biology. Our<br />
lab is developing novel technologies to study AP-1 in<br />
cancer cells and in C. elegans. Our recent publications<br />
include papers published in The EMBO Journal,<br />
(25:1058,2006), BioTechniques(40:61, 2006), Nature<br />
protocol (3:588, 3:1693, 2008), PNAS (105:101, 2008),<br />
Cancer Research (68:9663, 2008), and Trends in Biotechnology<br />
(26:622, 2008). TEL: (765) 496-1971 FAX:<br />
(765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/hu.php<br />
Email: cdhu@pharmacy.purdue.edu<br />
Xuehong Deng, Han Liu, Jiaoti Huang, Liang Cheng, Evan<br />
T. Keller, Sarah J. Parsons and Chang-Deng Hu, Ionizing radiation<br />
induces prostate cancer neuroendocrine differentiation<br />
through interplay of CREB and ATF2: Implications for<br />
Laboratory 3R and University of Basel. Computational<br />
Chemistry; Medicinal and/or Pharmaceutical Chemistry.<br />
Development of novel concepts for computer-aided drug<br />
discovery with incorporation of protein flexibility. Focus<br />
on quantifying binding affinities. Application focus on<br />
lead optimization and drug metabolism. TEL: (765) 496-<br />
9375 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/?uid=mlill<br />
Email: mlill@purdue.edu<br />
Angelo Vedani, Martin Zumstein, Markus A. Lill and Beat<br />
Ernst, Simulating / selectivity at the human thyroid hormone<br />
receptor: consensus scoring using multidimensional<br />
QSAR, ChemMedChem, 2, 78-87 (2007).<br />
Markus A. Lill and Angelo Vedani, Computational modeling<br />
of receptor-mediated toxicity, Comput. Toxicol, 315-351,<br />
4 plates (2007).<br />
Markus A. Lill, Multi-dimensional QSAR in drug discovery,<br />
Drug Discovery Today, 12, 1013-1017 (2007).<br />
Nima Sharifi, Ernest Hamel, Markus A. Lill, Prabhakar<br />
Risbood, Charles T. Kane, Jr., Md Tafazzal Hossain, Amanda<br />
Jones, James T. Dalton and William L. Farrar, A bifunctional<br />
colchicinoid that binds to the androgen receptor, Mol.<br />
Cancer Ther, 6, 2328-2336 (2007).<br />
Qing Jiang, Xinmin Yin, Markus A. Lill, Matthew L. Danielson,<br />
Helene Freiser and Jianjie Huang, Long-chain carbox-<br />
ychromanols, metabolites of vitamin E, are potent inhibitors<br />
sponses in the hormetic concentration range, Amer. J. Pharmacol.<br />
Toxicol, 3, 16-26 (2008).<br />
Ziying Jiang, Nina M. Gorenstein, Dorothy M. Morre and<br />
D. James Morre, Molecular cloning and characterization of a<br />
candidate human growth-related and time-keeping constitu-<br />
tive cell surface hydroquinone (NADH) oxidase, Biochemis-<br />
try, 47, 14018-14038 (2008).<br />
Dorothy M. Morre, D. James Morre, Winfield Rehmus and<br />
Dale Kern, Supplementation with CoQ10 lowers age-related<br />
(ar) NOX levels in healthy subjects, BioFactors, 32, 221-230<br />
(2008).<br />
D. James Morre and Dorothy M. Morre, arNOX activity of<br />
saliva as a non-invasive measure of coenzyme Q10 response<br />
in human trials, BioFactors, 32, 231-235 (2008).<br />
Kader Yagiz, P. W. Snyder, D. James Morre and Dorothy<br />
M. Morre, Cell size increased in tissues from transgenic mice<br />
overexpressing a cell surface growth-related and cancer-spe-<br />
cific hydroquinone oxidase, tNOX, with protein disulfide-thiol<br />
interchange activity, J. Cell. Biochem, 105, 1437-1442<br />
(2008).<br />
Elsa Janle, Dorothy M. Morre, D. James Morre, Q. Zhou,<br />
H. Chang and Y. Zhu, Pharmacokinetics of green tea catech-<br />
ins in extract and sustained-release preparations, J. Dietary<br />
Supplements, 5, 248-263 (2008).<br />
D. James Morre, Ziying Jiang, Milorad Marjanovic, John<br />
Orczyk and Dorothy M. Morre, Response of the regulatory<br />
behavior of copperII disease progression, Cancer Res, 68, 9663-9670 (2008). of cyclooxygenases, Proc. Natl. Acad. Sci, 105, 20464-20469<br />
-containing ECTO-NOX proteins and<br />
CuII Susan M. Hiatt, Y. John Shyu, Holli M. Duren and Chang- (2008).<br />
Cl2 in solution to electromagnetic fields, J. Inorg. Biochem,<br />
102, 1812-1818 (2008).<br />
Deng Hu, Bimolecular fluorescence complementation (BiFC)<br />
analysis of protein interactions in Caenorhabditis elegans,<br />
Methods (Oxford, U. K.), 45, 185-191 (2008).<br />
LOUDON, G. MARC (b.1942) Cwalina Distinguished<br />
Professor of Med. Chem. & Mol. Pharm. B.S, 1964,<br />
D. James Morre, John Orczyk, Heather Hignite and Chinpal<br />
Kim, Regular oscillatory behavior of aqueous solutions of<br />
CuII salts related to equilibrium dynamics of ortho/para hy-
4 <strong>PURDUE</strong><br />
drogen spin isomers of water, J. Inorg. Biochem, 102, 260-<br />
267 (2008).<br />
Jessica Kromkowski, Heather Hignite, Dorothy M. Morre<br />
and D. James Morre, Response to lithium of a cell surface<br />
ECTO-NOX protein with time-keeping characteristics, Neurosci.<br />
Lett, 438, 121-125 (2008).<br />
Xiaoyu Tang, D. James Morre and Dorothy M. Morre, Antisense<br />
experiments demonstrate an exon 4 minus splice variant<br />
mRNA as the basis for expression of tNOX, a cancer-specific<br />
cell surface protein, Oncol. Res, 16, 557-567 (2008).<br />
D. James Morre and Dorothy M. Morre, ENOX proteins,<br />
copper hexahydrate-based ultridian oscillators of the cells’<br />
biological clock, Ultradian Rhythms from Molecules to<br />
Mind: A New Vision of Life, 43-84 (2008).<br />
gy landscapes of proteins by using proteolysis as a structural<br />
probe. By using proteolysis we can monitor protein<br />
folding and unfolding under unconventional conditions,<br />
such as cell lysates, or on a proteomic scale. We also develop<br />
proteomic tools to identify cellular drug targets by<br />
monitoring stability changes upon drug binding on a proteomic<br />
scale. TEL: (765) 496-7513 FAX: (765) 494-<br />
1414<br />
Web: people.pharmacy.purdue.edu/~park6/index.html<br />
Email: chiwook@purdue.edu<br />
Chiwook Park, Sharleen Zhou, Jacqueline Gilmore and Susan<br />
Marqusee, Energetics-based Protein Profiling on a Pro-<br />
teomic Scale: Identification of Proteins Resistant to Proteolysis,<br />
J. Mol. Biol, 368, 1426-1437 (2007).<br />
Email: driese@purdue.edu<br />
David J. Riese, II, Richard M. Gallo and Jeffrey Settleman,<br />
Mutational activation of ErbB family receptor tyrosine ki-<br />
nases: insights into mechanisms of signal transduction and<br />
tumorigenesis, BioEssays, 29, 558-565 (2007).<br />
Nadia Godin-Heymann, Ianthe Bryant, Miguel N. Rivera,<br />
Lindsey Ulkus, Daphne W. Bell, David J. Riese, II, Jeffrey<br />
Settleman and Daniel A. Haber, Oncogenic Activity of Epidermal<br />
Growth Factor Receptor Kinase Mutant Alleles Is Enhanced<br />
by the T790M Drug Resistance Mutation, Cancer<br />
Res, 67, 7319-7326 (2007).<br />
Richard M. Gallo and David J. Riese, II, The antibody sc-<br />
33040-R fails to specifically recognize phosphorylation of<br />
ErbB4 on tyrosine1056, Growth Factors, 25, 329-333<br />
(2007).<br />
NICHOLS, DAVID E. (b.1944) Professor. B.S, 1969,<br />
University of Cincinnati; Ph.D, 1973, University of<br />
Iowa. Postdoctoral Fellowship, 1973-1974, University of<br />
Iowa. Medicinal and/or Pharmaceutical Chemistry; Neuroscience.<br />
Synthesis and structure-activity relationships<br />
of drugs affecting the central nervous system. Synthesis<br />
of rigid analogs of neurotransmitters and related molecules.<br />
Hallucinogens. Molecular pharmacology. Molecular<br />
modeling of GPCRs. Drugs to treat Parkinson’s disease,<br />
and to improve memory and cognitive deficits in<br />
schizophrenia. TEL: (765) 494-1461 FAX: (765) 494-<br />
1414<br />
Web: www.mcmp.purdue.edu/faculty/nichols.php<br />
Email: drdave@purdue.edu<br />
Alejandra Gallardo-Godoy, Melissa I. Torres-Altoro, Kellie<br />
J. White, Eric L. Barker and David E. Nichols, 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate)<br />
iodide, MTS-<br />
MPP<br />
Chiwook Park, Effects of salt and pH on binding and catalysis<br />
by ribonuclease A. (D)<br />
PARKER, LAURIE L. Assistant Professor. B.A,<br />
2000, University of St. Thomas; Ph.D, 2003, University<br />
of Glasgow. Postdoctoral Fellow, 2003-2008, University<br />
of Chicago. Bioengineering; Chemical Biology. Ourlab<br />
uses chemical biology and proteomics to develop biosen-<br />
sors for intracellular phosphorylation signaling. We will<br />
use synthetic peptide and protein chemistry to design and<br />
synthesize probes for multiplexed analysis of cancer-related<br />
signaling proteins e.g. Abl, other Src-family kinases,<br />
receptor tyrosine kinases, etc. TEL: (765) 496-<br />
3974 FAX: (765) 494-1414<br />
Web: ccehub.org/groups/parkerlab<br />
Email: llparker@purdue.edu<br />
Ding Wu, Michael R. Mand, Darren R. Veach, Laurie L.<br />
Richard M. Gallo and David J. Riese, II, Activating mutations<br />
of ErbB family receptor tyrosine kinases, Recent Prog.<br />
Cancer Res, 1-10 (2007).<br />
Jennifer L. GIlmore, Jeffrey A. Scott, Zhor Bouizar, Alex<br />
Robling, Sarah E. Pitfield, David J. Riese, II and John Foley,<br />
Amphiregulin-EGFR signaling regulates PTHrP gene expression<br />
in breast cancer cells, Breast Cancer Res. Treat, 110,<br />
493-505 (2008).<br />
S. Michael Rothenberg, Jeffrey A. Engelman, Sheila Le,<br />
David J. Riese, II, Daniel A. Haber and Jeffrey Settleman,<br />
Modeling oncogene addiction using RNA interference, Proc.<br />
Natl. Acad. Sci. U. S. A, 105, 12480-12484 (2008).<br />
Ianthe Nancy Bryant-Gawthrop, Regulation of tumor suppression<br />
by ErbB4. (M)<br />
Richard Michael Gallo, ErbB4 signal transduction and subcellular<br />
localization during prostate tumor suppression. (D)<br />
ROCHET, JEAN-CHRISTOPHE (b.1969) Asso-<br />
+ , a novel scanning cysteine accessibility method<br />
(SCAM) reagent for monoamine transporter studies, Bioorg.<br />
Med. Chem, 15, 305-311 (2007).<br />
Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul<br />
W. Czoty, David E. Nichols and Michael A. Nader, Ambient<br />
temperature effects on 3,4-methyl-<br />
enedioxymethamphetamine-induced thermodysregulation<br />
and pharmacokinetics in male monkeys, Drug Metab. Dispos,<br />
35, 1840-1845 (2007).<br />
Jonathan D. Urban, William P. Clarke, Mark von Zastrow,<br />
David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan<br />
A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M.<br />
Sexton, Keith J. Miller, Michael Spedding and Richard B.<br />
Mailman, Functional selectivity and classical concepts of<br />
quantitative pharmacology, J. Pharmacol. Exp. Ther, 320, 1-<br />
13 (2007).<br />
Michael R. Braden and David E. Nichols, Assessment of<br />
the roles of serines 5.43(239) and 5.46(242) for binding and<br />
potency of agonist ligands at the human serotonin 5-HT2A receptor,<br />
Mol. Pharmacol, 72, 1200-1209 (2007).<br />
Danuta Marona-Lewicka and David E. Nichols, Further<br />
evidence that the delayed temporal dopaminergic effects of<br />
LSD are mediated by a mechanism different than the first<br />
temporal phase of action, Pharmacol., Biochem. Behav, 87,<br />
453-461 (2007).<br />
Jennifer Selken and David E. Nichols, 1-Adrenergic receptors<br />
mediate the locomotor response to systemic administration<br />
of (±)-3,4-methylenedioxymethamphetamine<br />
(MDMA) in rats, Pharmacol., Biochem. Behav, 86, 622-630<br />
(2007).<br />
Matthew A. Parker, Deborah M. Kurrasch and David E.<br />
Nichols, The role of lipophilicity in determining binding affinity<br />
and functional activity for 5-HT2A receptor ligands, Bioorg.<br />
Med. Chem, 16, 4661-4669 (2008).<br />
David E. Nichols, Stewart P. Frescas, Benjamin R. Che-<br />
mel, Kenneth S. Rehder, Desong Zhong and Anita H. Lewin,<br />
High specific activity tritium-labeled N-(2-methoxybenzyl)-<br />
2,5-dimethoxy-4-iodophenethylamine (INBMeO): A high-affinity<br />
5-HT2A receptor-selective agonist radioligand, Bioorg.<br />
Med. Chem, 16, 6116-6123 (2008).<br />
Danielle M. Schultz, Jennifer A. Prescher, Stephanie Kidd,<br />
Danuta Marona-Lewicka, David E. Nichols and Aaron<br />
Monte, Hybrid benzofuran-benzopyran congeners as rigid<br />
analogs of hallucinogenic phenethylamines, Bioorg. Med.<br />
Chem, 16, 6242-6251 (2008).<br />
David E. Nichols and Charles D. Nichols, Serotonin Re-<br />
ceptors, Chem. Rev. (Washington, DC, U. S.), 108, 1614-<br />
1641 (2008).<br />
Crystal C. Walline, David E. Nichols, F. Ivy Carroll and<br />
Eric L. Barker, Comparative molecular field analysis using<br />
selectivity fields reveals residues in the third transmembrane<br />
helix of the serotonin transporter associated with substrate<br />
and antagonist recognition, J. Pharmacol. Exp. Ther, 325,<br />
791-800 (2008).<br />
Parker, Bayard Clarkson and Stephen J. Kron, A solid-phase<br />
Bcr-Abl kinase assay in 96-well hydrogel plates, Anal. Biochem,<br />
375, 18-26 (2008).<br />
Laurie L. Parker and Stephen J. Kron, Kinase activation in<br />
circulating cells: opportunities for biomarkers for diagnosis<br />
and therapeutic monitoring, Expert Opin. Med. Diagn, 2, 33-<br />
46 (2008).<br />
L. L. Parker, A. Engel-Hall, K. Drew, G. Steinhardt, D. L.<br />
Helseth, D. S. Angulo, D. Jabon, S. B. H. Kent and S. J.<br />
Kron, Investigating quantitation of phosphorylation using<br />
MALDI-TOF mass spectrometry, Journal of Mass Spectrometry,<br />
43, 518-527 (2008).<br />
POST, CAROL B. (b.1952) Professor. B.A, 1975,<br />
University of Arizona; Ph.D, 1981, University of California,<br />
San Diego. NIH Fellowship, 1982, Harvard University.<br />
Biophysics/Biophysical Chemistry; Computation-<br />
al Chemistry. Protein structure, protein-ligand interac-<br />
tions, and enzymatic catalysis using experimental NMR<br />
and molecular dynamics. TEL: (765) 494-5980 FAX:<br />
(765) 496-1189<br />
Web: bilbo.bio.purdue.edu/~postgrp<br />
Email: cbp@purdue.edu<br />
Carol B. Post, Transition states: substrate-induced conformational<br />
transitions, Handb. Proteins, 1, 541-547 (2007).<br />
Z. Zhou, C. Patkar, J. Suk, M. Khaliq, L. Li and C. B. Post,<br />
Antiviral compounds discovered by virtual screening of<br />
small-molecule libraries against dengue virus E protein, ACS<br />
Chemical Biology (cover title), 3, 765-775 (2008).<br />
Z. Li, M. Khaliq, Z. Zhou, C. B. Post, R. J. Kuhn and M.<br />
Cushman, Design, synthesis, and biological evaluation of an-<br />
tiviral agents targeting flavivirus envelope protein, J. Med.<br />
Chem, 1, 4660-4671 (2008).<br />
V. M. Dadarlat and C. B. Post, Contribution of charged<br />
groups to the enthalpic stabilization of the folded states of<br />
globular proteins, J. Phys. Chem. B, 112, 6159-6167 (2008).<br />
Y. Zhang, H. Oh, R. A. Burton, J. W. Burgner, R. L. Geahlen<br />
and C. B. Post, Tyr130 phosphorylation triggers Syk release<br />
from antigen receptor by long-distance conformational<br />
uncoupling, PNAS, 105, 11760-11765 (2008).<br />
E. Ozkirmili, S. Singh, W. T. Miller and C. B. Post, An<br />
electrostatic network is functional in the long-range regula-<br />
tion of Src kinases, Protein Science (cover illustration),<br />
(2008).<br />
Elif Ozkirimli, Src kinase activation investigated by computational<br />
methods. (D)<br />
Jae-eun Suk, Structure and dynamic studies of viral capsid<br />
proteins. (D)<br />
Yajie Zhang, Characterization of structural and dynamic<br />
properties of Syk tandem SH2 domain and its interaction<br />
with diphosphorylated-ITAM Important in B cell signaling<br />
regulation. (D)<br />
ciate Professor. B.Sc, 1991, University of Alberta; Ph.D,<br />
1998, University of Alberta. Post-doctoral Fellow, 1999-<br />
2002, Harvard Medical School. Biochemistry; Neuroscience.<br />
Neurodegeneration, Parkinson’s disease, protein<br />
misassembly, amyloid, aggresome, synuclein, synuclein-<br />
opathy, protein-membrane interactions, chaperones,<br />
Hsp70, Hsp27, proteasome, autophagy, protein oxida-<br />
tion, mitochondria, mitochondrial toxins, neuroprotective<br />
agents, antioxidant response, DJ-1, methionine sulfoxide<br />
reductase, endoplasmic reticulum stress, neuron-glia interactions,<br />
methamphetamine neurotoxicity. TEL: (765)<br />
494-1413 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/rochet.php<br />
Email: jrochet@purdue.edu<br />
rochet@pharmacy.purdue.edu<br />
Stephanie D. Tammam, Jean-Christophe Rochet and Marie<br />
E. Fraser, Identification of the cysteine residue exposed by<br />
the conformational change in pig heart succinyl-CoA:3-keto-<br />
acid coenzyme A transferase on binding coenzyme A, Biochemistry,<br />
46, 10852-10863 (2007).<br />
Stanislav D. Zakharov, John D. Hulleman, Elena A. Dutseva,<br />
Yuri N. Antonenko, Jean-Christophe Rochet and William<br />
A. Cramer, Helical -Synuclein Forms Highly Conductive<br />
Ion Channels, Biochemistry, 46, 14369-14379 (2007).<br />
John D. Hulleman, Hamid Mirzaei, Emmanuel Guigard,<br />
Kellie L. Taylor, Soumya S. Ray, Cyril M. Kay, Fred E. Regnier<br />
and Jean-Christophe Rochet, Destabilization of DJ-1 by<br />
Familial Substitution and Oxidative Modifications: Implica-<br />
tions for Parkinson’s Disease, Biochemistry, 46, 5776-5789<br />
(2007).<br />
Lee R. Cambrea, Farzin Haque, Jeremy L. Schieler, Jean-<br />
Christophe Rochet and Jennifer S. Hovis, Effect of ions on<br />
the organization of phosphatidylcholine/phosphatidic acid bilayers,<br />
Biophys. J, 93, 1630-1638 (2007).<br />
J.-C. Rochet, Novel therapeutic strategies for the treatment<br />
of protein misfolding diseases, Expert Rev. Mol. Med, 9, 1-34<br />
(2007).<br />
S. Padalkar, J. D. Hulleman, R. Colby, P. Deb, K. Cunze-<br />
man, J.-C. Rochet, E. Stach and L. Stanciu, Diameter con-<br />
trolled silver and platinum nanowires on a new biological<br />
template, Nanotechnology, 18 (2007).<br />
Tiago Fleming Outeiro, Eirene Kontopoulos, Stephen M.<br />
Altmann, Irina Kufareva, Katherine E. Strathearn, Allison M.<br />
Amore, Catherine B. Volk, Michele M. Maxwell, Jean-Christophe<br />
Rochet, Pamela J. McLean, Anne B. Young, Ruben<br />
Abagyan, Mel B. Feany, Bradley T. Hyman and Aleksey G.<br />
Kazantsev, Sirtuin 2 Inhibitors Rescue -Synuclein-Mediat-<br />
ed Toxicity in Models of Parkinson’s Disease, Science<br />
(Washington, DC, U. S.), 317, 516-519 (2007).<br />
Fang Liu, Jagadish Hindupur, Jamie L. Nguyen, Katie J.<br />
Ruf, Junyi Zhu, Jeremy L. Schieler, Connie C. Bonham, Karl<br />
V. Wood, V. Jo Davisson and Jean-Christophe Rochet, Me-<br />
thionine sulfoxide reductase A protects dopaminergic cells<br />
J. P. Cueva, Inquiry into the structural and conformational<br />
requirements of -phenyldopamine-type ligands for selective<br />
dopamine D1 receptor activation. (D)<br />
M. R. Braden, Towards a biophysical understanding of hallucinogen<br />
action. (D)<br />
PARK, CHIWOOK Assistant Professor. B.S, 1991,<br />
Seoul National University; M.S, 1993, Seoul National<br />
University; Ph.D, 2000, University of Wisconsin-Madison.<br />
Postdoctoral Researcher, 2001-2005, University of<br />
California, Berkeley. Biophysics/Biophysical Chemistry;<br />
Structural Biology. We investigate conformational ener-<br />
RIESE, DAVID J., II (b.1965) Associate Professor.<br />
A.B, 1987, Wabash College; M.Phil, 1989, Yale Univer-<br />
sity; Ph.D, 1993, Yale University. USAMRMC Fellow,<br />
1993-1995, Yale University; ASAMRMC Assoc. Research<br />
Scientist, 1995-1997, Yale University. Molecular<br />
Biology; Pharmacology. ErbB family receptor tyrosine<br />
kinase signal transduction; Epidermal Growth Factor receptor<br />
(EGFR); tumor cell biology; mammary, prostate,<br />
lung, and pancreatic tumorigenesis. TEL: (765) 494-<br />
6091 FAX: (765) 494-1414<br />
Web: www.mcmp.purdue.edu/faculty/riese.php<br />
from Parkinson’s disease-related insults, Free Radical Biol.<br />
Med, 45, 242-255 (2008).<br />
J.-C. Rochet and J. L. Schieler, The use of cell-free systems<br />
to characterize Parkinson’s disease-related gene products,<br />
In: Nass, R. & Przedborski, S., eds. Parkinson’s Disease:<br />
Molecular and Therapeutic Insights from Model Sys-<br />
tems. San Diego, CA: Elsevier, 597-627 (2008).<br />
J.-C. Rochet and J. D. Hulleman, Alpha-synuclein self-assembly<br />
in Parkinson’s disease: Insights from biophysical<br />
analyses, In: Outeiro, T. F., ed. Protein Misfolding in Biolo-<br />
gy and Disease. Trivandrum, India: Research Signpost, 151-<br />
180 (2008).<br />
R. Colby, J. D. Hulleman, S. Padalkar, J.-C. Rochet and L.
A. Stanciu, Biotemplated synthesis of metallic nanoparticle<br />
chains on an alpha-synuclein fiber scaffold, J. Nanosci. Nanotechnol,<br />
8, 973-978 (2008).<br />
Fang Liu, Jamie L. Nguyen, John D. Hulleman, Li Li and<br />
Jean-Christophe Rochet, Mechanisms of DJ-1 neuroprotection<br />
in a cellular model of Parkinson’s disease, J. Neurochem,<br />
105, 2435-2453 (2008).<br />
S. Padalkar, J. D. Hulleman, J.-C. Rochet, E. A. Stach and<br />
L. A. Stanciu, Protein-templated semiconductor nanoparticle<br />
chains, Nanotechnology, 19 (2008).<br />
Aaron D. Gitler, Brooke J. Bevis, James Shorter, Katherine<br />
E. Strathearn, Shusei Hamamichi, Linhui Julie Su, Kim A.<br />
Caldwell, Guy A. Caldwell, Jean-Christophe Rochet, J. Michael<br />
McCaffery, Charles Barlowe and Susan Lindquist, The<br />
Parkinson’s disease protein -synuclein disrupts cellular Rab<br />
homeostasis, Proc. Natl. Acad. Sci. U. S. A, 105, 145-150<br />
(2008).<br />
J. D. Hulleman, Regulation of DJ-1 structure and function:<br />
Implications for Parkinson’s disease. (D)<br />
SVENSSON, CRAIG K. (b.1957) Dean and Professor.<br />
D.Phil, 1981, University of Maryland; Ph.D, 1985,<br />
State University of New York at Buffalo. Postdoctoral<br />
Research Associate, 1984-1985, State University of New<br />
York at Buffalo. Pharmacology. Adverse Drug Reactions;<br />
Drug Hypersensitivity. TEL: (765) 494-1368<br />
FAX: (765) 494-7880<br />
Web: www.mcmp.purdue.edu/faculty/?uid=svensson<br />
Email: svensson@purdue.edu<br />
Sanjoy Roychowdhury, Albert E. Cram, Al Aly and Craig<br />
K. Svensson, Detection of haptenated proteins in organotypic<br />
human skin explant cultures exposed to dapsone, Drug Metab.<br />
Dispos, 35, 1463-1465 (2007).<br />
Sanjoy Roychowdhury, Piyush M. Vyas and Craig K.<br />
Svensson, Formation and uptake of arylhydroxylamine-haptenated<br />
proteins in human dendritic cells, Drug Metab. Dispos,<br />
35, 676-681 (2007).<br />
Farah D. Khan, Piyush M. Vyas, Anthony A. Gaspari and<br />
Craig K. Svensson, Effect of arylhydroxylamine metabolites<br />
of sulfamethoxazole and dapsone on stress signal expression<br />
in human keratinocytes, J. Pharmacol. Exp. Ther, 323, 771-<br />
777 (2007).<br />
Craig K. Svensson and Jean-Michel Scherrmann, Current<br />
advances and future directions for CNS delivery, AAPS Journal,<br />
10, 587-588 (2008).<br />
Craig K. Svensson, Drug Eruptions, Clinical and Basic Immunodermatology,<br />
263-276 (2008).<br />
Sree D. Panuganti and Craig K. Svensson, Drug clearance,<br />
Preclin. Dev. Handb.: ADME Biopharm. Prop, 715-742<br />
(2008).<br />
WATTS, VAL J. (b.1966) Associate Professor. B.S,<br />
1990, Ohio Northern University; Ph.D, 1994, University<br />
of North Carolina. NARSAD Young Investigator, NIH<br />
Training Fellowship, 1995-1998, Oregone Health and<br />
Science University. Neuroscience; Pharmacology. D2<br />
dopamine receptor signaling, selective modulators of D1<br />
and D5 dopamine receptors, G proteins, Dexras1, PKC<br />
modulation of adenylyl cyclases, RGS proteins, heterologous<br />
sensitization of recombinant adenylyl cyclases, behavioral<br />
sensitization. TEL: (765) 496-3872 FAX: (765)<br />
494-1414<br />
Web: people.pharmacy.purdue.edu/~vwatts/<br />
Email: wattsv@pharmacy.purdue.edu<br />
V. J. Watts, Adenylyl cyclase isoforms as novel therapeutic<br />
targets: an exciting example of excitotoxicity neuroprotection,<br />
Mol. Interventions, 7, 70-73 (2007).<br />
J. A. Chester and V. J. Watts, Adenylyl cyclase 5: A new<br />
clue in the search for the “fountain of youth‘?, Sci STKE,<br />
pe64 (2007).<br />
P. A. Vidi, J. Chen, J. M. K. Irudayaraj and V. J. Watts,<br />
Adenosine A2A receptors assemble into higher-order oligomers<br />
at the plasma membrane, FEBS Letters, 582, 3985-<br />
3990 (2008).<br />
F. S. Willard, Z. Zheng, J. Guo, G. J. Digby, A. J. Kimple,<br />
J. M. Conley, C. A. Johnston, D. Bosch, M. D. Willard, V. J.<br />
Watts, K. A. Lambert, S. R. Ikeda, Q. Du and D. P. Siderovski,<br />
A point mutation to Galphai selectively blocks GoLoco<br />
motif binding: Direct evidence for Galpha.GoLoco complexes<br />
in mitotic spindle dynamics, J. Biol. Chem, 283,<br />
36698-36710 (2008).<br />
P. A. Vidi, B. R. Chemel, C.-D. Hu and V. J. Watts, Ligand-dependent<br />
oligomerization of dopamine D2 and adenosine<br />
A2A receptors in living neuronal cells, Mol. Pharmacol,<br />
74, 544-551 (2008).<br />
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