PURDUE UNIVERSITY

PURDUE 1 

PURDUE UNIVERSITY 

575 Stadium Mall Drive, MCMP Dept, 1333 Robert E. 

Heine Pharmacy Building, Room 202 

West Lafayette, IN 47907-2091 

TEL: (765) 494-1403 

FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu 

Email: borch@purdue.edu 

Department of Medicinal Chemistry and Molecular 

Pharmacology 

Richard F. Borch, M.D., Ph.D., Department Head. 

Degrees Offered: M.S, Ph.D. 

Fields of Specialization: Medicinal Chemistry, Pharmacology. 

Interdisciplinary Program: Cancer Research Center, 

Purdue University Interdisciplinary Life Science PhD 

Program (PULSe). 

bonds catalyzed by palladium: An efficient approach for high 

throughput optimizations and kinetic studies, Advanced Synthesis 

& Catalysis, 350, 71-75 (2008). 

Shiyue Fang, Yousheng Guan, Ernest R. Blatchley, Chengyue 

Shen and Donald E. Bergstrom, Conjugation of (E)-5- 

[2-(Methoxycarbonyl)ethenyl]cytidine to Hydrophilic Microspheres: 

Development of a Mobile Microscale UV Light Actinometer, 

Bioconjugate Chem, 19, 592-597 (2008). 

Mohammad Ahmadian and Donald E. Bergstrom, 5-substituted 

nucleosides in biochemistry and biotechnology, Modified 

Nucleosides in Biochemistry, Biotechnoloy and Medicine, 

P. Herdewijn, ed. Wiley-VCH, Weinheim, 251-276 

(2008). 

E. R. Blatchley III, C. Shen , O. K. Scheible, J. P. Robinson, 

K. Ragheb, D. E. Bergstrom and D. Rokjer, Validation 

of large-scale, monochromatic UV disinfection systems for 

drinking water using dyed microspheres, Water Research, 

42, 677-688 (2008). 

S. Abd-El-Mawla, Azocarboxamide ribonucleoside tri- 

phosphates: synthesis, site-specific incorporation into RNA 

and incorporation studies with bovine diarrhea virus polymerase. 

(D) 

Email: cjchang@pharmacy.purdue.edu 

John M. Pezzuto, Richard C. Moon, Charles K.-H. Chang 

and Ching-jer Chang, New approach for evaluating the antibreast 

cancer activity of traditional Chinese medicine, Annals 

of Traditional Chinese Medicine, 3, 321-346 (2007). 

Her-Shyong Shiah, Wan-Shu Lee, Shin-Hun Juang, Pao- 

Chiung Hong, Chia-Chi Lung, Ching-Jer Chang, Kai-Ming 

Chou and Jang-Yang Chang, Mitochondria-mediated and 

p53-associated apoptosis induced in human cancer cells by a 

novel selenophene derivative, D-501036, Biochem. Pharma- 

col, 73, 610-619 (2007). 

Shin-Hun Juang, Chia-Chi Lung, Pi-Chen Hsu, Kuo-Shun 

Hsu, Yu-Chen Li, Pao-Chiung Hong, Her-Shyong Shiah, 

Ching-Chuan Kuo, Ching-Wei Huang, Yu-Chin Wang, Leey- 

uan Huang, Tom S. Chen, Shyh-Fong Chen, Kuo-Chu Fu, 

Cheng-Li Hsu, Meng-Ju Lin, Ching-jer Chang, Curtis L. 

Ashendel, Thomas C. K. Chan, Kai-Ming Chou and Jang- 

Yang Chang, D-501036, a novel selenophene-based triheter- 

ocycle derivative, exhibits potent in vitro and in vivo antitumoral 

activity which involves DNA damage and ataxia telangiectasia-mutated 

nuclear protein kinase activation, Mol. 

Cancer Ther, 6, 193-202 (2007). 

ASHENDEL, CURTIS L. (b.1955) Associate Professor. 

B.S, 1977, Michigan State University; Ph.D, 1982, 

University of Wisconsin, Madison. Bioinformatics; Molecular 

Biology. Current interest is computational genomics 

and systems biology. Specific interest is in sup- 

plementing genomic modeling and analysis algorithms 

with automated scientific reasoning. Cellular regulatory 

systems are my primary specific application area, includ- 

ing gene regulatory networks. Major applications include 

mechanisms of oncogenesis and other common human 

diseases, including type II diabetes. TEL: (765) 494- 

1479 FAX: (000) 000-0000 

Web: www.mcmp.purdue.edu/faculty/ashendel.php 

Email: ashendel@purdue.edu 

Shin-Hun Juang, Chia-Chi Lung, Pi-Chen Hsu, Kuo-Shun 

Hsu, Yu-Chen Li, Pao-Chiung Hong, Her-Shyong Shiah, 

Ching-Chuan Kuo, Ching-Wei Huang, Yu-Chin Wang, Leey- 

uan Huang, Tom S. Chen, Shyh-Fong Chen, Kuo-Chu Fu, 

Cheng-Li Hsu, Meng-Ju Lin, Ching-jer Chang, Curtis L. 

Ashendel, Thomas C. K. Chan, Kai-Ming Chou and Jang- 

Yang Chang, D-501036, a novel selenophene-based triheter- 

ocycle derivative, exhibits potent in vitro and in vivo antitu- 

moral activity which involves DNA damage and ataxia telan- 

giectasia-mutated nuclear protein kinase activation, Mol. 

Cancer Ther, 6, 193-202 (2007). 

BARKER, ERIC L. (b.1965) Associate Professor. 

B.S, 1988, St. Louis College of Pharmacy; Ph.D, 1993, 

Vanderbilt University. Research Associate, 1993-1995, 

Emory University; NIH Fellowship, 1995-1998, Vanderbilt 

University. Neuroscience; Pharmacology. Structurefunction 

of neurotransmitter transporters. TEL: (765) 

494-9940 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/barker.php 

Email: barkerel@purdue.edu 

Alejandra Gallardo-Godoy, Melissa I. Torres-Altoro, Kellie 

J. White, Eric L. Barker and David E. Nichols, 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) 

iodide, MTS- 

MPP 

BORCH, RICHARD F. (b.1941) Lilly Distinguished 

Professor and Head. B.S, 1962, Stanford University; 

Ph.D, 1965, Columbia University; M.D, 1975, University 

of Minnesota. NIH Postdoctoral Fellowship, 1965- 

1966, Harvard University. Medicinal and/or Pharmaceu- 

tical Chemistry. Design, synthesis and mechanisms of 

action of antitumor agents. Phosphopeptidomimetic prodrugs. 

TEL: (765) 494-1403 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/borch.php 

Email: borch@purdue.edu 

Michelle K. Clark, Sarah A. Scott, Jonathan Wojtkowiak, 

Rosemarie Chirco, Patricia Mathieu, John J. Reiners, Jr., 

Raymond R. Mattingly, Richard F. Borch and Richard A. 

Gibbs, Synthesis, Biochemical, and Cellular Evaluation of 

Farnesyl Monophosphate Prodrugs as Farnesyltransferase Inhibitors, 

J. Med. Chem, 50, 3274-3282 (2007). 

Weidong Wu, Jennifer Sigmond, Godefridus J. Peters and 

Richard F. Borch, Synthesis and Biological Activity of a 

Gemcitabine Phosphoramidate Prodrug, J. Med. Chem, 50, 

3743-3746 (2007). 

Irene G. Boutselis, Xiao Yu, Zhong-Yin Zhang and Richard 

F. Borch, Synthesis and Cell-Based Activity of a Potent 

and Selective Protein Tyrosine Phosphatase 1B Inhibitor Prodrug, 

J. Med. Chem, 50, 856-864 (2007). 

Jun Young Choi and Richard F. Borch, Highly Efficient 

Synthesis of Enantiomerically Enriched 2-Hydroxymethylaziridines 

by Enzymatic Desymmetrization, Org. Lett, 9, 

215-218 (2007). 

Meihua Luo, Sarah Delaplane, Aihua Jiang, April Reed, 

Ying He, Melissa Fishel, Rodney L. Nyland II, Richard F. 

Borch, Xiaoxi Qiao, Millie M. Georgiadis and Mark R. Kel- 

ley, Role of the Multifunctional DNA Repair and Redox Sig- 

naling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: 

Small-Molecule Inhibition of the Redox Function of Ape1, 

Antioxid. Redox Signaling, 10, 1853-1868 (2008). 

Jonathan W. Wojtkowiak, Farid Fouad, Daniel T. LaLonde, 

Miriam D. Kleinman, Richard A. Gibbs, John J. Reiners, 

Jr., Richard F. Borch and Raymond R. Mattingly, Induc- 

tion of apoptosis in neurofibromatosis type 1 malignant pe- 

ripheral nerve sheath tumor cell lines by a combination of 

COLBY, DAVID A. (b.1977) Assistant Professor. 

Ph.D, 2006, University of California, Irvine. Postdoctoral 

Researcher, 2006-2008, The Scripps Research Institute. 

Medicinal and/or Pharmaceutical Chemistry; Organic 

Chemistry. Our research group blends the science 

of medicinal chemistry and synthetic organic chemistry 

through the use of natural product synthesis, the design 

of structurally-related analogues for structure-activity investigations, 

and the development of new synthetic 

methodologies. Specifically, we seek to use natural products 

as leads for drug discovery in drug-resistant cancer 

and infectious diseases. Also, we develop new synthetic 

methodologies to modify the structures of natural products. 

TEL: (765) 496-3962 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/?uid=dcolby 

Email: dcolby@purdue.edy 

Hayato Ishikawa, David A. Colby and Dale L. Boger, Direct 

Coupling of Catharanthine and Vindoline to Provide 

Vinblastine: Total Synthesis of (+)- and ent-(-)-Vinblastine, 

J. Am. Chem. Soc, 130, 420-421 (2008). 

CUSHMAN, MARK (b.1945) Professor. Pharm.D, 

1969, University of California, San Francisco; Ph.D, 

1973, University of California, San Francisco. NIH Postdoctoral 

Fellowship, 1973-1975, Massachusetts Institute 

of Technology (MIT); Senior Fulbright Scholar, 1983- 

1984, Munich Technical University. Medicinal and/or 

Pharmaceutical Chemistry; Organic Chemistry. Design 

and synthesis of potential antitumor, antiviral, and antibiotic 

agents. TEL: (765) 494-1465 FAX: (765) 494-6790 

Web: www.mcmp.purdue.edu/faculty/cushman.php 

Email: cushman@purdue.edu 

Johannes Kaiser, Boris Illarionov, Felix Rohdich, Wolfgang 

Eisenreich, Sabine Saller, Jan Van Den Brulle, Mark 

Cushman, Adelbert Bacher and Markus Fischer, A high- 

throughput screening platform for inhibitors of the riboflavin 

biosynthesis pathway, Anal. Biochem, 365, 52-61 (2007). 

Ha Young Kim, Richard J. Kuhn, Chinmay Patkar, Ranjit 

+, a novel scanning cysteine accessibility method 

(SCAM) reagent for monoamine transporter studies, Bioorg. 

Med. Chem, 15, 305-311 (2007). 

novel farnesyl transferase inhibitors and lovastatin, J. Pharmacol. 

Exp. Ther, 326, 1-11 (2008). 

Warrier and Mark Cushman, Synthesis of dioxane-based an- 

tiviral agents and evaluation of their biological activities as 

inhibitors of Sindbis virus replication, Bioorg. Med. Chem, 

Ekaterina A. Placzek, Yasuo Okamoto, Natsuo Ueda and 

Eric L. Barker, Mechanisms for recycling and biosynthesis of 

endogenous cannabinoids anandamide and 2-arachidonylgly- 

Rodney L Nyland II, Design and synthesis of novel quinones 

targeting the redox function of APE1/REF-1. (D) 

15, 2667-2679 (2007). 

Smitha Antony, Keli K. Agama, Ze-Hong Miao, Kazutaka 

Takagi, Mollie H. Wright, Ana I. Robles, Lyuba Varticovski, 

cerol, J. Neurochem, 107, 987-1000 (2008). 

Crystal C. Walline, David E. Nichols, F. Ivy Carroll and 

Eric L. Barker, Comparative molecular field analysis using 

selectivity fields reveals residues in the third transmembrane 

helix of the serotonin transporter associated with substrate 

and antagonist recognition, J. Pharmacol. Exp. Ther, 325, 

791-800 (2008). 

Matthew J. McFarland, Tamera K. Bardell, Marla L. 

Yates, Ekaterina A. Placzek and Eric L. Barker, RNA interference-mediated 

knockdown of dynamin 2 reduces endocannabinoid 

uptake into neuronal dCAD cells, Mol. Pharmacol, 

74, 101-108 (2008). 

BERGSTROM, DONALD E. (b.1943) Walther Professor. 

B.S, 1965, University of Washington, Seattle, 

WA; Ph.D, 1970, University of California, Berkeley. 

Postdoctoral Fellowship, 1970-1972, University of Illi- 

nois. Medicinal and/or Pharmaceutical Chemistry; 

Nanochemistry. Nucleic acid chemistry; biotechnology 

and nanotechnology of re-engineered nucleic acids; design 

and synthesis of nucleoside analogs. TEL: (765) 

494-6275 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/?uid=dbergstr 

Email: bergstrom@purdue.edu 

Roya R. Lahiji, Bridget D. Dolash, Donald E. Bergstrom 

and Ronald Reifenberger, Oligodeoxyribonucleotide association 

with single-walled carbon nanotubes studied by SPM, 

Small, 3, 1912-1920 (2007). 

Roman V. Rozhkov, V. Jo Davisson and Donald E. Bergstrom, 

Fluorogenic transformations based on formation of CC 

BOROWITZ, JOSEPH L. (b.1932) Professor. B.S, 

1955, Ohio State University; M.S, 1957, Purdue Univer- 

sity; Ph.D, 1959, Northwestern University. NSF Postdoc- 

toral Fellow, 1960-1962, Harvard Medical School. Cell 

Biology. trimethyltin neurotoxicology; mechanisms of 

cyanide neurotoxicity. TEL: (765) 494-1407 FAX: (765) 

494-1414 

Web: www.mcmp.purdue.edu/faculty/borowitz.php 

Email: borowitz@pharmacy.purdue.edu 

Heather B. Leavesley, Li Li, Krishnan Prabhakaran, Joseph 

L. Borowitz and Gary E. Isom, Interaction of Cyanide and 

Nitric Oxide with Cytochrome c Oxidase: Implications for 

Acute Cyanide Toxicity, Toxicol. Sci, 101, 101-111 (2008). 

Joseph L. Borowitz and Gary E. Isom, Nicotine and Type 2 

Diabetes, Toxicol. Sci, 103, 225-227 (2008). 

CHANG, CHING-JER (b.1942) Professor. B.S, 1965, 

National Taiwan Cheng Kung University; Ph.D, 1972, 

Indiana University. Postdoctoral Fellowship, 1972, Pur- 

due University. Medicinal and/or Pharmaceutical Chemistry; 

Natural Products Chemistry. Discovery and design 

of oncogene signal transduction inhibitors; isolation, 

structure elucidation and synthesis of bioactive natural 

products; natural chemopreventive agents; bioorganic 

chemistry of cyclodextrins; enzymatic synthesis and biotransformation 

of bioactive compounds. TEL: (765) 494- 

1373 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/chang.php 

Muthukaman Nagarajan, Andrew Morrell, Mark Cushman 

and Yves Pommier, Novel Indenoisoquinolines NSC 725776 

and NSC 724998 Produce Persistent Topoisomerase I Cleavage 

Complexes and Overcome Multidrug Resistance, Cancer 

Res, 67, 10397-10405 (2007). 

Smitha Antony, Keli K. Agama, Ze-Hong Miao, Kazutaka 

Takagi, Mollie H. Wright, Ana I. Robles, Lyuba Varticovski, 

Muthukaman Nagarajan, Andrew Morrell, Mark Cushman 

and Yves Pommier, Novel indenoisoquinolines NSC 725776 

and NSC 724998 produce persistent topoisomerase I cleavage 

complexes and overcome multidrug resistance. [Erratum 

to document cited in CA148:092441], Cancer Res, 67, 12034 

(2007). 

Chan Yong Lee, Boris Illarionov, Young-Eun Woo, Kristina 

Kemter, Ryu-Ryun Kim, Sabine Eberhardt, Mark Cush- 

man, Wolfgang Eisenreich, Markus Fischer and Adelbert 

Bacher, Ligand binding properties of the N-terminal domain 

of riboflavin synthase from Escherichia coli, J. Biochem. 

Mol. Biol, 40, 239-246 (2007). 

Ekaterina Morgunova, Sabine Saller, Ilka Haase, Mark 

Cushman, Adelbert Bacher, Markus Fischer and Rudolf Ladenstein, 

Lumazine Synthase from Candida albicans as an 

Anti-fungal Target Enzyme: Structural and Biochemical Ba- 

sis for Drug Design, J. Biol. Chem, 282, 17231-17241 

(2007). 

Andrew Morrell, Michael S. Placzek, Jamin D. Steffen, 

Smitha Antony, Keli Agama, Yves Pommier and Mark Cush- 

man, Investigation of the Lactam Side Chain Length Neces- 

sary for Optimal Indenoisoquinoline Topoisomerase I Inhibition 

and Cytotoxicity in Human Cancer Cell Cultures, J. 

Med. Chem, 50, 2040-2048 (2007).

2 PURDUE 

Arup Maiti, Muriel Cuendet, Vicki L. Croy, Denise C. En- mel, William E. Fogler, Gregory E. Agoston, Phillip E. Fan- tive Syk Tyrosine Kinase for the Study of Signaling Dynamdringer, 

John M. Pezzuto and Mark Cushman, Synthesis and wick and Mark Cushman, Stereoselective Synthesis of 3,3- ics from the B Cell Antigen Receptor, J. Biol. Chem, 282, 

Biological Evaluation of (±)-Abyssinone II and Its Ana- Diarylacrylonitriles as Tubulin Polymerization Inhibitors, J. 33760-33768 (2007). 

logues as Aromatase Inhibitors for Chemoprevention of Org. Chem, 73, 4241-4244 (2008). 

Fei Zhou, Jacob Galan, Robert L. Geahlen and W. Andy 

Breast Cancer, J. Med. Chem, 50, 2799-2806 (2007). 

Yunlong Song and Mark Cushman, The Binding Orienta- Tao, A Novel Quantitative Proteomics Strategy To Study 

Takeshi Sakamoto, Matthew D. Cullen, Tracy L. Hartman, tion of a Norindenoisoquinoline in the Topoisomerase I- Phosphorylation-Dependent Peptide-Protein Interactions, J. 

Karen M. Watson, Robert W. Buckheit, Christophe Pannec- DNA Cleavage Complex Is Primarily Governed by - Proteome Res, 6, 133-140 (2007). 

ouque, Erik De Clercq and Mark Cushman, Synthesis and Stacking Interactions, J. Phys. Chem. B, 112, 9484-9489 Jun Wang, Ning Bao, Leela L. Paris, Hsiang-Yu Wang, 

Anti-HIV Activity of New Metabolically Stable Alkenyldia- (2008). Robert L. Geahlen and Chang Lu, Detection of Kinase Transrylmethane 

Non-Nucleoside Reverse Transcriptase Inhibitors Matthew Cullen, Deborah Miles, Arlene Rothwell, Connie location Using Microfluidic Electroporative Flow Cytometry, 

Incorporating N-Methoxy Imidoyl Halide and 1,2,4-Oxadia- Bonham, Karl V. Wood and Mark Cushman, Hydrolysis of Anal. Chem. (Washington, DC, U. S.), 80, 1087-1093 (2008). 

zole Systems, J. Med. Chem, 50, 3314-3321 (2007). 

thioesters in an ion trap, Rapid Commun. Mass Spectrom, 22, Jun Wang, Ning Bao, Leela L. Paris, Robert L. Geahlen 

Arup Maiti, Muriel Cuendet, Tamara Kondratyuk, Vicki L. 1094-1098 (2008). and Chang Lu, Total Internal Reflection Fluorescence Flow 

Croy, John M. Pezzuto and Mark Cushman, Synthesis and 

Cytometry, Anal. Chem. (Washington, DC, U. S.), 80, 9840- 

Cancer Chemopreventive Activity of Zapotin, a Natural 

Product from Casimiroa edulis, J. Med. Chem, 50, 350-355 

(2007). 

Andrew Morrell, Michael Placzek, Seth Parmley, Brian 

Grella, Smitha Antony, Yves Pommier and Mark Cushman, 

Optimization of the Indenone Ring of Indenoisoquinoline 

Topoisomerase I Inhibitors, J. Med. Chem, 50, 4388-4404 

(2007). 

Andrew Morrell, Michael Placzek, Seth Parmley, Smitha 

Antony, Thomas S. Dexheimer, Yves Pommier and Mark 

Cushman, Nitrated Indenoisoquinolines as Topoisomerase I 

Inhibitors: A Systematic Study and Optimization, J. Med. 

Chem, 50, 4419-4430 (2007). 

Matthew D. Cullen, Bo-Liang Deng, Tracy L. Hartman, 

Karen M. Watson, Robert W. Buckheit, Jr., Christophe Pannecouque, 

Erik De Clercq and Mark Cushman, Synthesis and 

Biological Evaluation of Alkenyldiarylmethane HIV-1 Non- 

Nucleoside Reverse Transcriptase Inhibitors That Possess Increased 

Hydrolytic Stability, J. Med. Chem, 50, 4854-4867 

Juma Hoshino, Design and synthesis of analogs and metabolites 

of resveratrol as chemopreventive agents. (M) 

Katherine E. Peterson, Investigation of the stereochemical 

effects of the indenoisoquinoline side chain on topoisomerase 

i inhibition. (M) 

Yanlei Zhang, Design, synthesis and bioevaluation of lumazine 

synthase inhibitors. (M) 

Andrew Edward O’Dell Morrell, Development of topoisomerase 

I inhibitors as anticancer agents. (D) 

Matthew David Cullen, Investigations on alkenyldiarylmethase 

HIV-1 reverse transcriptase inhibitors: Mechanism of 

action, synthesis, and metabolic evaluation of hydrolytically 

stable analogues. (D) 

DAVISSON, VINCENT JO (b.1955) Professor. B.A, 

1978, Wittenberg University; M.S, 1983, Indiana Uni- 

versity; Ph.D, 1988, University of Utah. Postdoctoral 

Fellowship, 1987-1989, University of California, San 

Francisco, Department of Biochemistry and Biophysics. 

9844 (2008). 

Thibaud Lebouvier, Timothy M. E. Scales, Diane P. Hanger, 

Robert L. Geahlen, Bernard Lardeux, C. Hugh Reynolds, 

Brian H. Anderton and Pascal Derkinderen, The microtubuleassociated 

protein tau is phosphorylated by Syk, Biochim. 

Biophys. Acta, Mol. Cell Res, 1783, 188-192 (2008). 

Manqing Li, Su Sien Ong, Bartek Rajwa, Vivian T. Thieu, 

Robert L. Geahlen and Marietta L. Harrison, The SH3 domain 

of Lck modulates T-cell receptor-dependent activation 

of extracellular signal-regulated kinase through activation of 

Raf-1, Mol. Cell. Biol, 28, 630-641 (2008). 

Yajie Zhang, Hyunju Oh, Robert A. Burton, John W. 

Burgner, Robert L. Geahlen and Carol Beth Post, Tyr130 

phosphorylation triggers Syk release from antigen receptor 

by long-distance conformational uncoupling, Proc. Natl. 

Acad. Sci. U. S. A, 105, 11760-11765 (2008). 

GHOSH, ARUN K.—See Chemistry Section, Purdue 

University, Department of Chemistry. 

(2007). 

Allison B. Edsall, Gregory E. Agoston, Anthony M. Treston, 

Stacy M. Plum, Robert H. McClanahan, Tian-Sheng 

Lu, Wei Song and Mark Cushman, Synthesis and in Vivo 

Antitumor Evaluation of 2-Methoxyestradiol 3-Phosphate, 

17-Phosphate, and 3,17-Diphosphate, J. Med. Chem, 50, 

6700-6705 (2007). 

Yanlei Zhang, Boris Illarionov, Adelbert Bacher, Markus 

Fischer, Gunda I. Georg, Qi-Zhuang Ye, David Vander 

Velde, Phillip E. Fanwick, Yunlong Song and Mark Cushman, 

A Novel Lumazine Synthase Inhibitor Derived from 

Oxidation of 1,3,6,8-Tetrahydroxy-2,7-naphthyridine to a 

Tetraazaperylenehexaone Derivative, J. Org. Chem, 72, 

2769-2776 (2007). 

Arindam Talukdar, Boris Illarionov, Adelbert Bacher, 

Markus Fischer and Mark Cushman, Synthesis and Enzyme 

Inhibitory Activity of the S-Nucleoside Analogue of the Ribitylaminopyrimidine 

Substrate of Lumazine Synthase and 

Product of Riboflavin Synthase, J. Org. Chem, 72, 7167- 

7175 (2007). 

Yanlei Zhang, Guangyi Jin, Boris Illarionov, Adelbert 

Bacher, Markus Fischer and Mark Cushman, A New Series 

of 3-Alkyl Phosphate Derivatives of 4,5,6,7-Tetrahydro-1-Dribityl-1H-pyrazolo[3,4-d]pyrimidinedione 

as Inhibitors of 

Lumazine Synthase: Design, Synthesis, and Evaluation, J. 

Org. Chem, 72, 7176-7184 (2007). 

Muriel Cuendet, Carol P. Oteham, Arup Maiti, Bruce A. 

Craig, Mark Cushman, Richard C. Moon and John M. Pezzuto, 

Zapotin prevents mouse skin tumorigenesis during the 

stages of initiation and promotion, Anticancer Research, 28, 

3705-3709 (2008). 

Tsyr-Yan Yu, Robert D. O’Connor, Astrid C. Sivertsen, 

Colby Chiauzzi, Barbara Poliks, Markus Fischer, Adelbert 

Bacher, Ilka Haase, Mark Cushman and Jacob Schaefer, 

15N{31P} REDOR NMR studies of the binding of phosphonate 

reaction intermediate analogues to saccharomyces cerevisiae 

lumazine synthase, Biochemistry, 47, 13942–13951 

(2008). 

Matthew D. Cullen, York-Fong Cheung, Miles D. Houslay, 

Tracy L. Hartman, Karen M. Watson, Robert W. Buckheit, 

Christophe Pannecouque, Erik De Clercq and Mark 

Cushman, Investigation of the alkenyldiarylmethane non-nucleoside 

reverse transcriptase inhibitors as potential cAMP 

phosphodiesterase-4B2 inhibitors, Bioorg. Med. Chem. Lett, 

18, 1530-1533 (2008). 

Matthew D. Cullen, Taradas Sarkar, Ernest Hamel, Tracy 

L. Hartman, Karen M. Watson, Robert W. Buckheit, Christophe 

Pannecouque, Erik De Clercq and Mark Cushman, Inhibition 

of tubulin polymerization by select alkenyldiarylmethanes, 

Bioorg. Med. Chem. Lett, 18, 469-473 (2008). 

Maris A. Cinelli, Andrew Morrell, Thomas S. Dexheimer, 

Evan S. Scher, Yves Pommier and Mark Cushman, Design, 

Synthesis, and Biological Evaluation of 14-Substituted Aromathecins 

as Topoisomerase I Inhibitors, J. Med. Chem, 51, 

4609-4619 (2008). 

Ze Li, Mansoora Khaliq, Zhigang Zhou, Carol Beth Post, 

Richard J. Kuhn and Mark Cushman, Design, Synthesis, and 

Biological Evaluation of Antiviral Agents Targeting Flavivirus 

Envelope Proteins, J. Med. Chem, 51, 4660-4671 (2008). 

Yanlei Zhang, Boris Illarionov, Ekaterina Morgunova, 

Guangyi Jin, Adelbert Bacher, Markus Fischer, Rudolf Ladenstein 

and Mark Cushman, A New Series of N-[2,4-Dioxo- 

6-D-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic 

Acid Derivatives as Inhibitors of Lumazine Synthase and Riboflavin 

Synthase: Design, Synthesis, Biochemical Evaluation, 

Crystallography, and Mechanistic Implications, J. Org. 

Chem, 73, 2715-2724 (2008). 

Zhenglai Fang, Yunlong Song, Taradas Sarkar, Ernest Ha- 

Chemical Biology; Medicinal and/or Pharmaceutical 

Chemistry. Medicinal Chemistry and cellular pharmacology 

of natural product drugs. Cell based and biomolecular 

assay tools for drug discovery and development in 

cancer and neurodegenerative diseases. Targeting of 

small molecules to disease-specific receptors; analysis of 

small molecules agonists and antagonists of regulatory 

protein interactions. TEL: (765) 494-5238 FAX: (765) 

494-1414 

Web: www.mcmp.purdue.edu/faculty/davisson.php 

Email: davisson@purdue.edu 

R. E. Amaro, R. S. Myers, V. J. Davisson and Z. A. Luthey-Schulten, 

A network of conserved interactions regulates 

the allosteric signal in a glutamine amidotransferase, Biochemistry, 

46, 2156-2173 (2007). 

D. Schweitzer, J. Zhu, G. Jarori, J. J. Kane, J. Tanaka, T. 

Higa, V. J. Davisson and P. Helquist, Synthesis of carbamate 

derivatives of iejimalides. Retention of normal antiproliferative 

activity and localization of binding in cancer cells, 

Bioorganic and Medicinal Chemistry, 15, 3208-3216 (2007). 

R. Rozhkov, V. J. Davisson and D. E. Bergstrom, Fluorogenic 

tranformations based on formation of C-C bonds cata- 

lyzed by palladium: An efficient approach for high through- 

put optimizations and kinetic studies, Advanced Synthesis 

and Catalysis, 350, 71-75 (2008). 

S. K. Deb, B. Davis, D. Ben-Amotz and V. J. Davisson, 

Accurate concentration measurements using surface-enhanced 

raman and deuterium exchanged dye pairs, Applied 

Spectroscopy, 62, 1001-1007 (2008). 

G. M. Knudsen, B. M. Davis, S. K. Deb, Y. Loethen, R. 

Gudihal, P. Perera, D. Ben-Amotz and V. J. Davisson, Quantification 

of isotope encoded proteins in 2-D gels using surface 

enhanced resonance raman, Bioconjugate Chem, 19, 

2212-2220 (2008). 

S. M. Firestine, W. Wu, H. Youn and V. J. Davisson, Interrogating 

the mechanism of a tight binding inhibitor of AIR 

carboxylase, Bioorganic and Medicinal Chemistry, 17, 794- 

803 (2008). 

F. Liu, J. Hindupur, J. L. Nguyen, K. J. Ruf, J. Zhu, J. L. 

Schieler, C. C. Bonham, K. V. Wood, V. J. Davisson and J.- 

L. Rochet, Methionine sulfoxide reductase A protects dopaminergic 

cells from Parkinson’s disease-related insults, Free 

Radical Biology & Medicine, 45, 242-255 (2008). 

S. K. Deb, B. Davis, G. M. Knudsen, R. Gudihal, D. Ben- 

Amotz and V. J. Davisson, Detection and relative quantification 

of proteins by surface enhanced raman using isotopic labels, 

J. Am. Chem. Soc, 30, 9624-9625 (2008). 

Y. L. Loethen, G. M. Knudsen, B. Davis, R. Gudihal, V. J. 

Davisson and D. Ben-Amotz, Protein quantitation in 2-D gels 

using fluorescence with water raman as an internal standard, 

J. Proteome Res, 7, 1341-1345 (2008). 

GEAHLEN, ROBERT L. (b.1953) Professor. B.S, 

1975, University of Southern Colorado; Ph.D, 1978, 

University of Wyoming. Postdoctoral Fellowship, 1978, 

University of Washington; NIH Fellowship, 1978, University 

of Washington; Juvenile Diabetes Foundation 

Fellowship, 1980, University of Washington. Biochemistry; 

Immunology. Protein-tyrosine kinases and lymphocyte 

activation; tyrosine kinases and breast cancer; protein 

acylation; antitumor agents. TEL: (765) 494-1457 

FAX: (765) 494-9193 

Web: www.mcmp.purdue.edu/faculty/geahlen.php 

Email: geahlen@purdue.edu 

Hyunju Oh, Elif Ozkirimli, Kavita Shah, Marietta L. Harrison 

and Robert L. Geahlen, Generation of an Analog-sensi- 

GIBBS, RICHARD A. (b.1961) Professor. B.S, 1983, 

Johns Hopkins University; Ph.D, 1988, University of California, 

Riverside. NSF Fellowship, 1988-1991, Penn 

State University. Chemical Biology; Medicinal and/or 

Pharmaceutical Chemistry. Chemical probes of protein 

prenylation; mechanistic studies of the enzyme proteinfarnesyl 

transferase; inhibitors of the enzyme isoprenylcysteine 

methyltransferase; novel methods for the synthesis 

of isoprenoid analogs. TEL: (765) 494-1456 FAX: 

(765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/gibbs.php 

Email: rgibbs@purdue.edu 

Amanda J. Krzysiak, Diwan S. Rawat, Sarah A. Scott, June 

E. Pais, Misty Handley, Marietta L. Harrison, Carol A. 

Fierke and Richard A. Gibbs, Combinatorial Modulation of 

Protein Prenylation, ACS Chem. Biol, 2, 385-389 (2007). 

Amanda J. Krzysiak, Sarah A. Scott, Katherine A. Hicks, 

Carol A. Fierke and Richard A. Gibbs, Evaluation of protein 

farnesyltransferase substrate specificity using synthetic peptide 

libraries, Bioorg. Med. Chem. Lett, 17, 5548-5551 

(2007). 

Michelle K. Clark, Sarah A. Scott, Jonathan Wojtkowiak, 

Rosemarie Chirco, Patricia Mathieu, John J. Reiners, Jr., 

Raymond R. Mattingly, Richard F. Borch and Richard A. 

Gibbs, Synthesis, Biochemical, and Cellular Evaluation of 

Farnesyl Monophosphate Prodrugs as Farnesyltransferase In- 

hibitors, J. Med. Chem, 50, 3274-3282 (2007). 

Linda Henneman, Arno G. van Cruchten, Simone W. 

Denis, Michael J. Amolins, Andrew T. Placzek, Richard A. 

Gibbs, Willem Kulik and Hans R. Waterham, Isoprenoid de- 

tection by tandem mass spectrometry, Analytical Biochemis- 

try, 383, 18-24 (2008). 

Michelle Maynor, Sarah A. Scott, Emily L. Rickert and 

Richard A. Gibbs, Synthesis and evaluation of 3- and 7-sub- 

stituted geranylgeranyl pyrophosphate analogs, Bioorg. Med. 

Chem. Lett, 18, 1889-1892 (2008). 

Diwan S. Rawat, Amanda J. Krzysiak and Richard A. 

Gibbs, Synthesis and Biochemical Evaluation of 3,7-Disubstituted 

Farnesyl Diphosphate Analogues, J. Org. Chem, 73, 

1881-1887 (2008). 

Jonathan W. Wojtkowiak, Farid Fouad, Daniel T. LaLonde, 

Miriam D. Kleinman, Richard A. Gibbs, John J. Reiners, 

Jr., Richard F. Borch and Raymond R. Mattingly, Induction 

of apoptosis in neurofibromatosis type 1 malignant pe- 

ripheral nerve sheath tumor cell lines by a combination of 

novel farnesyl transferase inhibitors and lovastatin, J. Pharmacol. 

Exp. Ther, 326, 1-11 (2008). 

Amanda J. Krzysiak, Modulating Farnesyltransferase substrate 

specificity: Tools for altering protein function in vivo. 

(D) 

James L. Donelson, A new solid-phase route to prenylcysteine 

derivatives: Development of isoprenylcysteine carboxyl 

methyltransferase inhibitors. (D) 

HARRISON, MARIETTA L. (b.1948) Professor. 

B.A, 1970, University of New Hampshire; Ph.D, 1980, 

University of Wyoming. Cancer Research Institute Fellowship, 

1980, Fred Hutchinson Cancer Research Cen- 

ter; NIH Fellowship, 1981, Fred Hutchinson Cancer Research 

Center and Purdue University. Biochemistry; Immunology. 

Our research involves investigating the role of 

cellular protein-tyrosine kinases in cell division and dif- 

ferentiation. TEL: (765) 494-1442 FAX: (765) 494-9193 

Web: www.mcmp.purdue.edu/faculty/harrison.php

PURDUE 3 

Email: harrisom@purdue.edu 

Amanda J. Krzysiak, Diwan S. Rawat, Sarah A. Scott, June 

E. Pais, Misty Handley, Marietta L. Harrison, Carol A. 

Fierke and Richard A. Gibbs, Combinatorial Modulation of 

Protein Prenylation, ACS Chem. Biol, 2, 385-389 (2007). 

Maia M. Donahue, Wei Zhang, Marietta L. Harrison, Jianghai 

Hu and Ann E. Rundell, Employing optimization and 

sensitivity analyses tools to generate and analyze mathematical 

models of T cell signaling events, AIP Conf. Proc, 953, 

43-63 (2007). 

Hyunju Oh, Elif Ozkirimli, Kavita Shah, Marietta L. Harrison 

and Robert L. Geahlen, Generation of an Analog-sensitive 

Syk Tyrosine Kinase for the Study of Signaling Dynamics 

from the B Cell Antigen Receptor, J. Biol. Chem, 282, 

33760-33768 (2007). 

Manqing Li, Su Sien Ong, Bartek Rajwa, Vivian T. Thieu, 

Robert L. Geahlen and Marietta L. Harrison, The SH3 domain 

of Lck modulates T-cell receptor-dependent activation 

of extracellular signal-regulated kinase through activation of 

Raf-1, Mol. Cell. Biol, 28, 630-641 (2008). 

A. T. Krans, Dephosphorylation of Phosphoserine 59 in the 

Protein Tyrosine Kinase, Lck. (M) 

M. B. Baker, The Effect of Serine 59 Phosphorylation on 

the Conformation of the Protein Binding Domains of the Pro- 

tein Tyrosine Kinase Lck. (D) 

M. D. Handley, Anchors away: An alternative role for farnesylation 

of Ras. (D) 

M. L. Vázquez, Biological Consequences of the Phosphorylation 

of Serine 59 on the Tyrosine Kinase Lck. (D) 

HAZBUN, TONY R. Assistant Professor. B.Sc, 1989, 

University of Queensland; Ph.D, 1997, University of Notre 

Dame. Research Associate, 1998-2005, Howard 

Hughes Medical Institute. Bioinformatics; Genetics. 

Functional genomics, Systems Biology, Mitosis, Proteinprotein 

interactions, Two-hybrid, Chemical genetics, Aurora 

kinase, Bub1 kinase, genetic interactions. TEL: 

(765) 496-8228 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/?uid=hazbun 

Email: thazbun@purdue.edu 

J. Wong, Y. Nakajima, S. Westermann, C. Shang C. Goodner, 

P. Houshmand, C. Chan, S. Fields, D. G. Drubin, G. 

Barnes and T. Hazbun, A protein interaction map of the mitotic 

spindle, Mol Biol Cell, 18, 3800-09 (2007). 

HOCKERMAN, GREGORY H. (b.1961) Associate 

Professor. B.S, 1983, Olivet Nazarene College; Ph.D, 

1991, University of Wisconsin. NIH Fellowship, 1991- 

1997, University of Washington. Pharmacology; Physi- 

ology. Molecular determinants of dihydropyridine, phenylalkylamine 

and benzothiazepine block of L-type cal- 

cium channels; synthesis of novel calcium channel 

blockers as research tools, L-type calcium channel mod- 

ulation of insulin secretion. TEL: (765) 496-3874 FAX: 

(765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/hockerman.php 

Email: gregh@pharmacy.purdue.edu 

Kenneth B. Walsh, Jining Zhang, John W. Fuseler, Nathan 

Hilliard and Gregory H. Hockerman, Adenoviral-mediated 

expression of dihydropyridine-insensitive L-type calcium 

channels in cardiac ventricular myocytes and fibroblasts, 

Eur. J. Pharmacol, 565, 7-16 (2007). 

X. Wang, R. Xu, G. Abernathey, J. Taylor, M. Alzghoul, 

K. Hannon, G. H. Hockerman and A Pond, Kv11.1 channel 

subunit composition varies developmentally in mouse cardiac 

muscle, Developmetal Dynamics, 237, 2430-2437 (2008). 

Pierre-Alexandre Vidi, Benjamin R. Chemel, Chang-Deng 

Hu and Val J. Watts, Ligand-dependent oligomerization of 

dopamine D2 and adenosine A2A receptors in living neuronal 

cells, Mol. Pharmacol, 74, 544-551 (2008). 

Y. John Shyu, Christopher D. Suarez and Chang-Deng Hu, 

Visualization of ternary complexes in living cells by using a 

BiFC-based FRET assay, Nat. Protoc, 3, 1693-1702 (2008). 

Y. John Shyu, Susan M. Hiatt, Holli M. Duren, Ronald E. 

Ellis, Tom K. Kerppola and Chang-Deng Hu, Visualization 

of protein interactions in living Caenorhabditis elegans using 

bimolecular fluorescence complementation analysis, Nat. 

Protoc, 3, 588-596 (2008). 

Y. John Shyu, Christopher D. Suarez and Chang-Deng Hu, 

Visualization of AP-1-NF-B ternary complexes in living 

cells by using a BiFC-based FRET, Proc. Natl. Acad. Sci. U. 

S. A, 105, 151-156 (2008). 

Y. John Shyu and Chang-Deng Hu, Fluorescence complementation: 

An emerging tool for biological research, Trends 

Biotechnol, 26, 622-630 (2008). 

Susan M. Hiatt, Understanding AP-1 dimerization in vivo: 

Genetic and BiFC analysis of C. elegans FOS-1 and JUN-1 

in regulation of ovulation. (D) 

Yeong-Shiun John Shyu, Understanding the role of ATF-1 

homodimers in Caenorhabditis elegans development using a 

novel bimolecular fluorescence complementation-based 

dominant dimeric repressor assay. (D) 

ISOM, GARY E. (b.1946) Professor. B.S, 1969, Idaho 

State University; Ph.D, 1973, Washington State University. 

Neuroscience; Toxicology. Biochemical mechanisms 

of neurotoxicity; excitotoxic neurotransmitters in 

xenobiotic neurotoxicity. TEL: (765) 494-5905 FAX: 

(765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/isom.php 

Email: geisom@purdue.edu 

Heather B. Leavesley, Li Li, Krishnan Prabhakaran, Joseph 

L. Borowitz and Gary E. Isom, Interaction of Cyanide and 

Nitric Oxide with Cytochrome c Oxidase: Implications for 

Acute Cyanide Toxicity, Toxicol. Sci, 101, 101-111 (2008). 

Joseph L. Borowitz and Gary E. Isom, Nicotine and Type 2 

Diabetes, Toxicol. Sci, 103, 225-227 (2008). 

LACOUNT, DOUGLAS J. (b.1970) Assistant professor. 

B.S, 1992, University of Wisconsin-Madison; Ph.D, 

1998, University of Wisconsin-Madison. post-doc, 1998- 

1002, University of Iowa; post-doc, 2001-2005, University 

of Washington. Molecular Biology; Virology. My 

current research focuses on interactions between host 

cells and obligate intracellular parasites. We seek to 

identify physical interactions between host cell proteins 

and viral or malaria proteins in order to better understand 

how intracellular parasites manipulate their hosts and to 

discover host cell proteins that are required for growth of 

multiple pathogens. TEL: (765) 496-7835 FAX: (765) 

494-1414 

Web: www.mcmp.purdue.edu/faculty/?uid=dlacount 

Email: dlacount@pharmacy.purdue.edu 

M. Vignali A. McKinlay, D. J. LaCount, R. Chettier, R. 

Bell, S. Sahasrabudhe, R. E. Hughes and S. Fields, Interaction 

of an atypical Plasmodium falciparum ETRAMP with 

human apolipoproteins, Malar J, 20, 211 (2008). 

LILL, MARKUS A. (b.1974) Assistant Professor. 

M.Sc, 1998, University of Erlangen-Nuernberg, Germany; 

Ph.D, 2002, Max Planck Institute for Biophysics, 

Germany. Research Associate, 2002-2006, Biographics 

Louisiana State University; Ph.D, 1968, University of 

California, Berkeley. Postdoctoral Fellowship, 1968- 

1970, University of California, Berkeley, Department of 

Biochemistry. Bioorganic Chemistry; Chemistry Education. 

Chemical mechanisms, bioorganic chemistry, 

chemical education with emphasis on organic chemistry. 

TEL: (765) 494-1462 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/loudon.php 

Email: loudonm@purdue.edu 

Animesh Aditya, David E. Nichols and G. Marc Loudon, 

Borohydride reduction of estrone. Demonstration of diaster- 

eoselectivity in the undergraduate organic chemistry labora- 

tory, Journal of Chemical Education, 85, 1585-1587 (2008). 

MORRÉ, D. JAMES (b.1935) Dow Distinguished 

Professor. B.S, 1957, University of Missouri; M.S, 1959, 

Purdue University; Ph.D, 1963, Caltech; D.h.c, 1985, 

University of Geneva; D.h.c, 2000, Universite Victor 

Segalen, Bordeaux, France. Biochemistry. Researches 

the biochemistry of cell growth and dynamics of intracellular 

membranes and is familiar with a wide range of in- 

vestigative approaches to elucidation of structure-function 

correlations in cell biology, subcellular biochemis- 

try, and medicinal chemistry. Recently described a novel 

universal cancer marker, designated tNOX, a protein lo- 

cated at the cell surface and having protein disulfide-thiol 

interchange/NADH oxidase activity that is growth re- 

lated and inhibited by anticancer drugs. TEL: (765) 494- 

1388 FAX: (765) 494-4007 

Web: www.mcmp.purdue.edu/faculty/morre.php 

Email: morred@purdue.edu 

Xiaoyu Tang, Zengsui Tian, Pin-Ju Chueh, Ssuhen Chen, 

Dorothy M. Morre and D. James Morre, Alternative Splicing 

as the Basis for Specific Localization of tNOX, a Unique Hy- 

droquinone (NADH) Oxidase, to the Cancer Cell Surface, 

Biochemistry, 46, 12337-12346 (2007). 

Raymond Cooper, Talash A. Likimani, D. James Morre 

and Dorothy M. Morre, Catechins and caffeine in tea: A review 

of health risks and benefits, Caffeine Act. Theory, 351- 

364 (2007). 

D. James Morre and Hilton H. Mollenhauer, Microscopic 

morphology and the origins of the membrane maturation 

model of Golgi apparatus function, Int. Rev. Cytol, 262, 191- 

218 (2007). 

Kader Yagiz, Lion-Ying Wu, Charles P. Kuntz, D. James 

Morre and Dorothy M. Morre, Mouse embryonic fibroblast 

cells from transgenic mice overexpressing tNOX exhibit an 

altered growth and drug response phenotype, J. Cell. Biochem, 

101, 295-306 (2007). 

D. James Morre, Steve Heald, Jason Coleman, John Orczyk, 

Ziying Jiang and Dorothy M. Morre, Structural observa- 

tions of time dependent oscillatory behavior of copper (II) 

chloride solutions measured via extended X-ray absorption 

fine structure, J. Inorg. Biochem, 101, 715-726 (2007). 

D. James Morre, P.-J. Chueh, Kader Yagiz, Andrew Balicki, 

Chinpal Kim and Dorothy M. Morre, ECTO-NOX target 

for the anticancer isoflavene phenoxodiol, Oncol. Res, 

16, 299-312 (2007). 

Connie M. Weaver, Stephen Barnes, J. Michael Wyss, Hel- 

en Kim, Dorothy M. Morre, D. James Morre, James E. Si- 

mon, Mary Ann Lila, Elsa M. Janle and Mario G. Ferruzzi, 

Botanicals for age-related diseases: from field to practice, 

Am. J. Clin. Nutr, 87, 493S-497S (2008). 

D. James Morre, Sara Dick, Elena Bosneaga, Andrew Bal- 

icki, Lian-Ying Wu, Nicole McClain and Dorothy M. Morre, 

tNOX (ENOX1) target for chemosensitization—low-dose re- 

Sarah Melissa P. Jacobo, Dichotomy of Cav1.2 and Cav1.3 

L-type Ca2+ channel function and modulation in GLP-1mediated 

insulin exocytosis and ERK1/2 activation in pancreatic 

beta cells. (D) 

HU, CHANG-DENG (b.1961) Associate Professor. 

M.D, 1984, Bengbu Medical College, China; M.S, 1987, 

Tongji Medical University, China; Ph.D, 1997, Kobe 

University School of Medicine, Japan. Research Investigator/Specialist, 

2000-2003, Univ. of Michigan School 

of Medicine. Cell Biology; Developmental Biology. Our 

lab is developing novel technologies to study AP-1 in 

cancer cells and in C. elegans. Our recent publications 

include papers published in The EMBO Journal, 

(25:1058,2006), BioTechniques(40:61, 2006), Nature 

protocol (3:588, 3:1693, 2008), PNAS (105:101, 2008), 

Cancer Research (68:9663, 2008), and Trends in Biotechnology 

(26:622, 2008). TEL: (765) 496-1971 FAX: 

(765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/hu.php 

Email: cdhu@pharmacy.purdue.edu 

Xuehong Deng, Han Liu, Jiaoti Huang, Liang Cheng, Evan 

T. Keller, Sarah J. Parsons and Chang-Deng Hu, Ionizing radiation 

induces prostate cancer neuroendocrine differentiation 

through interplay of CREB and ATF2: Implications for 

Laboratory 3R and University of Basel. Computational 

Chemistry; Medicinal and/or Pharmaceutical Chemistry. 

Development of novel concepts for computer-aided drug 

discovery with incorporation of protein flexibility. Focus 

on quantifying binding affinities. Application focus on 

lead optimization and drug metabolism. TEL: (765) 496- 

9375 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/?uid=mlill 

Email: mlill@purdue.edu 

Angelo Vedani, Martin Zumstein, Markus A. Lill and Beat 

Ernst, Simulating / selectivity at the human thyroid hormone 

receptor: consensus scoring using multidimensional 

QSAR, ChemMedChem, 2, 78-87 (2007). 

Markus A. Lill and Angelo Vedani, Computational modeling 

of receptor-mediated toxicity, Comput. Toxicol, 315-351, 

4 plates (2007). 

Markus A. Lill, Multi-dimensional QSAR in drug discovery, 

Drug Discovery Today, 12, 1013-1017 (2007). 

Nima Sharifi, Ernest Hamel, Markus A. Lill, Prabhakar 

Risbood, Charles T. Kane, Jr., Md Tafazzal Hossain, Amanda 

Jones, James T. Dalton and William L. Farrar, A bifunctional 

colchicinoid that binds to the androgen receptor, Mol. 

Cancer Ther, 6, 2328-2336 (2007). 

Qing Jiang, Xinmin Yin, Markus A. Lill, Matthew L. Danielson, 

Helene Freiser and Jianjie Huang, Long-chain carbox- 

ychromanols, metabolites of vitamin E, are potent inhibitors 

sponses in the hormetic concentration range, Amer. J. Pharmacol. 

Toxicol, 3, 16-26 (2008). 

Ziying Jiang, Nina M. Gorenstein, Dorothy M. Morre and 

D. James Morre, Molecular cloning and characterization of a 

candidate human growth-related and time-keeping constitu- 

tive cell surface hydroquinone (NADH) oxidase, Biochemis- 

try, 47, 14018-14038 (2008). 

Dorothy M. Morre, D. James Morre, Winfield Rehmus and 

Dale Kern, Supplementation with CoQ10 lowers age-related 

(ar) NOX levels in healthy subjects, BioFactors, 32, 221-230 

(2008). 

D. James Morre and Dorothy M. Morre, arNOX activity of 

saliva as a non-invasive measure of coenzyme Q10 response 

in human trials, BioFactors, 32, 231-235 (2008). 

Kader Yagiz, P. W. Snyder, D. James Morre and Dorothy 

M. Morre, Cell size increased in tissues from transgenic mice 

overexpressing a cell surface growth-related and cancer-spe- 

cific hydroquinone oxidase, tNOX, with protein disulfide-thiol 

interchange activity, J. Cell. Biochem, 105, 1437-1442 

(2008). 

Elsa Janle, Dorothy M. Morre, D. James Morre, Q. Zhou, 

H. Chang and Y. Zhu, Pharmacokinetics of green tea catech- 

ins in extract and sustained-release preparations, J. Dietary 

Supplements, 5, 248-263 (2008). 

D. James Morre, Ziying Jiang, Milorad Marjanovic, John 

Orczyk and Dorothy M. Morre, Response of the regulatory 

behavior of copperII disease progression, Cancer Res, 68, 9663-9670 (2008). of cyclooxygenases, Proc. Natl. Acad. Sci, 105, 20464-20469 

-containing ECTO-NOX proteins and 

CuII Susan M. Hiatt, Y. John Shyu, Holli M. Duren and Chang- (2008). 

Cl2 in solution to electromagnetic fields, J. Inorg. Biochem, 

102, 1812-1818 (2008). 

Deng Hu, Bimolecular fluorescence complementation (BiFC) 

analysis of protein interactions in Caenorhabditis elegans, 

Methods (Oxford, U. K.), 45, 185-191 (2008). 

LOUDON, G. MARC (b.1942) Cwalina Distinguished 

Professor of Med. Chem. & Mol. Pharm. B.S, 1964, 

D. James Morre, John Orczyk, Heather Hignite and Chinpal 

Kim, Regular oscillatory behavior of aqueous solutions of 

CuII salts related to equilibrium dynamics of ortho/para hy-

4 PURDUE 

drogen spin isomers of water, J. Inorg. Biochem, 102, 260- 

267 (2008). 

Jessica Kromkowski, Heather Hignite, Dorothy M. Morre 

and D. James Morre, Response to lithium of a cell surface 

ECTO-NOX protein with time-keeping characteristics, Neurosci. 

Lett, 438, 121-125 (2008). 

Xiaoyu Tang, D. James Morre and Dorothy M. Morre, Antisense 

experiments demonstrate an exon 4 minus splice variant 

mRNA as the basis for expression of tNOX, a cancer-specific 

cell surface protein, Oncol. Res, 16, 557-567 (2008). 

D. James Morre and Dorothy M. Morre, ENOX proteins, 

copper hexahydrate-based ultridian oscillators of the cells’ 

biological clock, Ultradian Rhythms from Molecules to 

Mind: A New Vision of Life, 43-84 (2008). 

gy landscapes of proteins by using proteolysis as a structural 

probe. By using proteolysis we can monitor protein 

folding and unfolding under unconventional conditions, 

such as cell lysates, or on a proteomic scale. We also develop 

proteomic tools to identify cellular drug targets by 

monitoring stability changes upon drug binding on a proteomic 

scale. TEL: (765) 496-7513 FAX: (765) 494- 

1414 

Web: people.pharmacy.purdue.edu/~park6/index.html 

Email: chiwook@purdue.edu 

Chiwook Park, Sharleen Zhou, Jacqueline Gilmore and Susan 

Marqusee, Energetics-based Protein Profiling on a Pro- 

teomic Scale: Identification of Proteins Resistant to Proteolysis, 

J. Mol. Biol, 368, 1426-1437 (2007). 

Email: driese@purdue.edu 

David J. Riese, II, Richard M. Gallo and Jeffrey Settleman, 

Mutational activation of ErbB family receptor tyrosine ki- 

nases: insights into mechanisms of signal transduction and 

tumorigenesis, BioEssays, 29, 558-565 (2007). 

Nadia Godin-Heymann, Ianthe Bryant, Miguel N. Rivera, 

Lindsey Ulkus, Daphne W. Bell, David J. Riese, II, Jeffrey 

Settleman and Daniel A. Haber, Oncogenic Activity of Epidermal 

Growth Factor Receptor Kinase Mutant Alleles Is Enhanced 

by the T790M Drug Resistance Mutation, Cancer 

Res, 67, 7319-7326 (2007). 

Richard M. Gallo and David J. Riese, II, The antibody sc- 

33040-R fails to specifically recognize phosphorylation of 

ErbB4 on tyrosine1056, Growth Factors, 25, 329-333 

(2007). 

NICHOLS, DAVID E. (b.1944) Professor. B.S, 1969, 

University of Cincinnati; Ph.D, 1973, University of 

Iowa. Postdoctoral Fellowship, 1973-1974, University of 

Iowa. Medicinal and/or Pharmaceutical Chemistry; Neuroscience. 

Synthesis and structure-activity relationships 

of drugs affecting the central nervous system. Synthesis 

of rigid analogs of neurotransmitters and related molecules. 

Hallucinogens. Molecular pharmacology. Molecular 

modeling of GPCRs. Drugs to treat Parkinson’s disease, 

and to improve memory and cognitive deficits in 

schizophrenia. TEL: (765) 494-1461 FAX: (765) 494- 

1414 

Web: www.mcmp.purdue.edu/faculty/nichols.php 

Email: drdave@purdue.edu 

Alejandra Gallardo-Godoy, Melissa I. Torres-Altoro, Kellie 

J. White, Eric L. Barker and David E. Nichols, 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) 

iodide, MTS- 

MPP 

Chiwook Park, Effects of salt and pH on binding and catalysis 

by ribonuclease A. (D) 

PARKER, LAURIE L. Assistant Professor. B.A, 

2000, University of St. Thomas; Ph.D, 2003, University 

of Glasgow. Postdoctoral Fellow, 2003-2008, University 

of Chicago. Bioengineering; Chemical Biology. Ourlab 

uses chemical biology and proteomics to develop biosen- 

sors for intracellular phosphorylation signaling. We will 

use synthetic peptide and protein chemistry to design and 

synthesize probes for multiplexed analysis of cancer-related 

signaling proteins e.g. Abl, other Src-family kinases, 

receptor tyrosine kinases, etc. TEL: (765) 496- 

3974 FAX: (765) 494-1414 

Web: ccehub.org/groups/parkerlab 

Email: llparker@purdue.edu 

Ding Wu, Michael R. Mand, Darren R. Veach, Laurie L. 

Richard M. Gallo and David J. Riese, II, Activating mutations 

of ErbB family receptor tyrosine kinases, Recent Prog. 

Cancer Res, 1-10 (2007). 

Jennifer L. GIlmore, Jeffrey A. Scott, Zhor Bouizar, Alex 

Robling, Sarah E. Pitfield, David J. Riese, II and John Foley, 

Amphiregulin-EGFR signaling regulates PTHrP gene expression 

in breast cancer cells, Breast Cancer Res. Treat, 110, 

493-505 (2008). 

S. Michael Rothenberg, Jeffrey A. Engelman, Sheila Le, 

David J. Riese, II, Daniel A. Haber and Jeffrey Settleman, 

Modeling oncogene addiction using RNA interference, Proc. 

Natl. Acad. Sci. U. S. A, 105, 12480-12484 (2008). 

Ianthe Nancy Bryant-Gawthrop, Regulation of tumor suppression 

by ErbB4. (M) 

Richard Michael Gallo, ErbB4 signal transduction and subcellular 

localization during prostate tumor suppression. (D) 

ROCHET, JEAN-CHRISTOPHE (b.1969) Asso- 

+ , a novel scanning cysteine accessibility method 

(SCAM) reagent for monoamine transporter studies, Bioorg. 

Med. Chem, 15, 305-311 (2007). 

Matthew L. Banks, Jon E. Sprague, David F. Kisor, Paul 

W. Czoty, David E. Nichols and Michael A. Nader, Ambient 

temperature effects on 3,4-methyl- 

enedioxymethamphetamine-induced thermodysregulation 

and pharmacokinetics in male monkeys, Drug Metab. Dispos, 

35, 1840-1845 (2007). 

Jonathan D. Urban, William P. Clarke, Mark von Zastrow, 

David E. Nichols, Brian Kobilka, Harel Weinstein, Jonathan 

A. Javitch, Bryan L. Roth, Arthur Christopoulos, Patrick M. 

Sexton, Keith J. Miller, Michael Spedding and Richard B. 

Mailman, Functional selectivity and classical concepts of 

quantitative pharmacology, J. Pharmacol. Exp. Ther, 320, 1- 

13 (2007). 

Michael R. Braden and David E. Nichols, Assessment of 

the roles of serines 5.43(239) and 5.46(242) for binding and 

potency of agonist ligands at the human serotonin 5-HT2A receptor, 

Mol. Pharmacol, 72, 1200-1209 (2007). 

Danuta Marona-Lewicka and David E. Nichols, Further 

evidence that the delayed temporal dopaminergic effects of 

LSD are mediated by a mechanism different than the first 

temporal phase of action, Pharmacol., Biochem. Behav, 87, 

453-461 (2007). 

Jennifer Selken and David E. Nichols, 1-Adrenergic receptors 

mediate the locomotor response to systemic administration 

of (±)-3,4-methylenedioxymethamphetamine 

(MDMA) in rats, Pharmacol., Biochem. Behav, 86, 622-630 

(2007). 

Matthew A. Parker, Deborah M. Kurrasch and David E. 

Nichols, The role of lipophilicity in determining binding affinity 

and functional activity for 5-HT2A receptor ligands, Bioorg. 

Med. Chem, 16, 4661-4669 (2008). 

David E. Nichols, Stewart P. Frescas, Benjamin R. Che- 

mel, Kenneth S. Rehder, Desong Zhong and Anita H. Lewin, 

High specific activity tritium-labeled N-(2-methoxybenzyl)- 

2,5-dimethoxy-4-iodophenethylamine (INBMeO): A high-affinity 

5-HT2A receptor-selective agonist radioligand, Bioorg. 

Med. Chem, 16, 6116-6123 (2008). 

Danielle M. Schultz, Jennifer A. Prescher, Stephanie Kidd, 

Danuta Marona-Lewicka, David E. Nichols and Aaron 

Monte, Hybrid benzofuran-benzopyran congeners as rigid 

analogs of hallucinogenic phenethylamines, Bioorg. Med. 

Chem, 16, 6242-6251 (2008). 

David E. Nichols and Charles D. Nichols, Serotonin Re- 

ceptors, Chem. Rev. (Washington, DC, U. S.), 108, 1614- 

1641 (2008). 

Crystal C. Walline, David E. Nichols, F. Ivy Carroll and 

Eric L. Barker, Comparative molecular field analysis using 

selectivity fields reveals residues in the third transmembrane 

helix of the serotonin transporter associated with substrate 

and antagonist recognition, J. Pharmacol. Exp. Ther, 325, 

791-800 (2008). 

Parker, Bayard Clarkson and Stephen J. Kron, A solid-phase 

Bcr-Abl kinase assay in 96-well hydrogel plates, Anal. Biochem, 

375, 18-26 (2008). 

Laurie L. Parker and Stephen J. Kron, Kinase activation in 

circulating cells: opportunities for biomarkers for diagnosis 

and therapeutic monitoring, Expert Opin. Med. Diagn, 2, 33- 

46 (2008). 

L. L. Parker, A. Engel-Hall, K. Drew, G. Steinhardt, D. L. 

Helseth, D. S. Angulo, D. Jabon, S. B. H. Kent and S. J. 

Kron, Investigating quantitation of phosphorylation using 

MALDI-TOF mass spectrometry, Journal of Mass Spectrometry, 

43, 518-527 (2008). 

POST, CAROL B. (b.1952) Professor. B.A, 1975, 

University of Arizona; Ph.D, 1981, University of California, 

San Diego. NIH Fellowship, 1982, Harvard University. 

Biophysics/Biophysical Chemistry; Computation- 

al Chemistry. Protein structure, protein-ligand interac- 

tions, and enzymatic catalysis using experimental NMR 

and molecular dynamics. TEL: (765) 494-5980 FAX: 

(765) 496-1189 

Web: bilbo.bio.purdue.edu/~postgrp 

Email: cbp@purdue.edu 

Carol B. Post, Transition states: substrate-induced conformational 

transitions, Handb. Proteins, 1, 541-547 (2007). 

Z. Zhou, C. Patkar, J. Suk, M. Khaliq, L. Li and C. B. Post, 

Antiviral compounds discovered by virtual screening of 

small-molecule libraries against dengue virus E protein, ACS 

Chemical Biology (cover title), 3, 765-775 (2008). 

Z. Li, M. Khaliq, Z. Zhou, C. B. Post, R. J. Kuhn and M. 

Cushman, Design, synthesis, and biological evaluation of an- 

tiviral agents targeting flavivirus envelope protein, J. Med. 

Chem, 1, 4660-4671 (2008). 

V. M. Dadarlat and C. B. Post, Contribution of charged 

groups to the enthalpic stabilization of the folded states of 

globular proteins, J. Phys. Chem. B, 112, 6159-6167 (2008). 

Y. Zhang, H. Oh, R. A. Burton, J. W. Burgner, R. L. Geahlen 

and C. B. Post, Tyr130 phosphorylation triggers Syk release 

from antigen receptor by long-distance conformational 

uncoupling, PNAS, 105, 11760-11765 (2008). 

E. Ozkirmili, S. Singh, W. T. Miller and C. B. Post, An 

electrostatic network is functional in the long-range regula- 

tion of Src kinases, Protein Science (cover illustration), 

(2008). 

Elif Ozkirimli, Src kinase activation investigated by computational 

methods. (D) 

Jae-eun Suk, Structure and dynamic studies of viral capsid 

proteins. (D) 

Yajie Zhang, Characterization of structural and dynamic 

properties of Syk tandem SH2 domain and its interaction 

with diphosphorylated-ITAM Important in B cell signaling 

regulation. (D) 

ciate Professor. B.Sc, 1991, University of Alberta; Ph.D, 

1998, University of Alberta. Post-doctoral Fellow, 1999- 

2002, Harvard Medical School. Biochemistry; Neuroscience. 

Neurodegeneration, Parkinson’s disease, protein 

misassembly, amyloid, aggresome, synuclein, synuclein- 

opathy, protein-membrane interactions, chaperones, 

Hsp70, Hsp27, proteasome, autophagy, protein oxida- 

tion, mitochondria, mitochondrial toxins, neuroprotective 

agents, antioxidant response, DJ-1, methionine sulfoxide 

reductase, endoplasmic reticulum stress, neuron-glia interactions, 

methamphetamine neurotoxicity. TEL: (765) 

494-1413 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/rochet.php 

Email: jrochet@purdue.edu 

rochet@pharmacy.purdue.edu 

Stephanie D. Tammam, Jean-Christophe Rochet and Marie 

E. Fraser, Identification of the cysteine residue exposed by 

the conformational change in pig heart succinyl-CoA:3-keto- 

acid coenzyme A transferase on binding coenzyme A, Biochemistry, 

46, 10852-10863 (2007). 

Stanislav D. Zakharov, John D. Hulleman, Elena A. Dutseva, 

Yuri N. Antonenko, Jean-Christophe Rochet and William 

A. Cramer, Helical -Synuclein Forms Highly Conductive 

Ion Channels, Biochemistry, 46, 14369-14379 (2007). 

John D. Hulleman, Hamid Mirzaei, Emmanuel Guigard, 

Kellie L. Taylor, Soumya S. Ray, Cyril M. Kay, Fred E. Regnier 

and Jean-Christophe Rochet, Destabilization of DJ-1 by 

Familial Substitution and Oxidative Modifications: Implica- 

tions for Parkinson’s Disease, Biochemistry, 46, 5776-5789 

(2007). 

Lee R. Cambrea, Farzin Haque, Jeremy L. Schieler, Jean- 

Christophe Rochet and Jennifer S. Hovis, Effect of ions on 

the organization of phosphatidylcholine/phosphatidic acid bilayers, 

Biophys. J, 93, 1630-1638 (2007). 

J.-C. Rochet, Novel therapeutic strategies for the treatment 

of protein misfolding diseases, Expert Rev. Mol. Med, 9, 1-34 

(2007). 

S. Padalkar, J. D. Hulleman, R. Colby, P. Deb, K. Cunze- 

man, J.-C. Rochet, E. Stach and L. Stanciu, Diameter con- 

trolled silver and platinum nanowires on a new biological 

template, Nanotechnology, 18 (2007). 

Tiago Fleming Outeiro, Eirene Kontopoulos, Stephen M. 

Altmann, Irina Kufareva, Katherine E. Strathearn, Allison M. 

Amore, Catherine B. Volk, Michele M. Maxwell, Jean-Christophe 

Rochet, Pamela J. McLean, Anne B. Young, Ruben 

Abagyan, Mel B. Feany, Bradley T. Hyman and Aleksey G. 

Kazantsev, Sirtuin 2 Inhibitors Rescue -Synuclein-Mediat- 

ed Toxicity in Models of Parkinson’s Disease, Science 

(Washington, DC, U. S.), 317, 516-519 (2007). 

Fang Liu, Jagadish Hindupur, Jamie L. Nguyen, Katie J. 

Ruf, Junyi Zhu, Jeremy L. Schieler, Connie C. Bonham, Karl 

V. Wood, V. Jo Davisson and Jean-Christophe Rochet, Me- 

thionine sulfoxide reductase A protects dopaminergic cells 

J. P. Cueva, Inquiry into the structural and conformational 

requirements of -phenyldopamine-type ligands for selective 

dopamine D1 receptor activation. (D) 

M. R. Braden, Towards a biophysical understanding of hallucinogen 

action. (D) 

PARK, CHIWOOK Assistant Professor. B.S, 1991, 

Seoul National University; M.S, 1993, Seoul National 

University; Ph.D, 2000, University of Wisconsin-Madison. 

Postdoctoral Researcher, 2001-2005, University of 

California, Berkeley. Biophysics/Biophysical Chemistry; 

Structural Biology. We investigate conformational ener- 

RIESE, DAVID J., II (b.1965) Associate Professor. 

A.B, 1987, Wabash College; M.Phil, 1989, Yale Univer- 

sity; Ph.D, 1993, Yale University. USAMRMC Fellow, 

1993-1995, Yale University; ASAMRMC Assoc. Research 

Scientist, 1995-1997, Yale University. Molecular 

Biology; Pharmacology. ErbB family receptor tyrosine 

kinase signal transduction; Epidermal Growth Factor receptor 

(EGFR); tumor cell biology; mammary, prostate, 

lung, and pancreatic tumorigenesis. TEL: (765) 494- 

6091 FAX: (765) 494-1414 

Web: www.mcmp.purdue.edu/faculty/riese.php 

from Parkinson’s disease-related insults, Free Radical Biol. 

Med, 45, 242-255 (2008). 

J.-C. Rochet and J. L. Schieler, The use of cell-free systems 

to characterize Parkinson’s disease-related gene products, 

In: Nass, R. & Przedborski, S., eds. Parkinson’s Disease: 

Molecular and Therapeutic Insights from Model Sys- 

tems. San Diego, CA: Elsevier, 597-627 (2008). 

J.-C. Rochet and J. D. Hulleman, Alpha-synuclein self-assembly 

in Parkinson’s disease: Insights from biophysical 

analyses, In: Outeiro, T. F., ed. Protein Misfolding in Biolo- 

gy and Disease. Trivandrum, India: Research Signpost, 151- 

180 (2008). 

R. Colby, J. D. Hulleman, S. Padalkar, J.-C. Rochet and L.

A. Stanciu, Biotemplated synthesis of metallic nanoparticle 

chains on an alpha-synuclein fiber scaffold, J. Nanosci. Nanotechnol, 

8, 973-978 (2008). 

Fang Liu, Jamie L. Nguyen, John D. Hulleman, Li Li and 

Jean-Christophe Rochet, Mechanisms of DJ-1 neuroprotection 

in a cellular model of Parkinson’s disease, J. Neurochem, 

105, 2435-2453 (2008). 

S. Padalkar, J. D. Hulleman, J.-C. Rochet, E. A. Stach and 

L. A. Stanciu, Protein-templated semiconductor nanoparticle 

chains, Nanotechnology, 19 (2008). 

Aaron D. Gitler, Brooke J. Bevis, James Shorter, Katherine 

E. Strathearn, Shusei Hamamichi, Linhui Julie Su, Kim A. 

Caldwell, Guy A. Caldwell, Jean-Christophe Rochet, J. Michael 

McCaffery, Charles Barlowe and Susan Lindquist, The 

Parkinson’s disease protein -synuclein disrupts cellular Rab 

homeostasis, Proc. Natl. Acad. Sci. U. S. A, 105, 145-150 

(2008). 

J. D. Hulleman, Regulation of DJ-1 structure and function: 

Implications for Parkinson’s disease. (D) 

SVENSSON, CRAIG K. (b.1957) Dean and Professor. 

D.Phil, 1981, University of Maryland; Ph.D, 1985, 

State University of New York at Buffalo. Postdoctoral 

Research Associate, 1984-1985, State University of New 

York at Buffalo. Pharmacology. Adverse Drug Reactions; 

Drug Hypersensitivity. TEL: (765) 494-1368 

FAX: (765) 494-7880 

Web: www.mcmp.purdue.edu/faculty/?uid=svensson 

Email: svensson@purdue.edu 

Sanjoy Roychowdhury, Albert E. Cram, Al Aly and Craig 

K. Svensson, Detection of haptenated proteins in organotypic 

human skin explant cultures exposed to dapsone, Drug Metab. 

Dispos, 35, 1463-1465 (2007). 

Sanjoy Roychowdhury, Piyush M. Vyas and Craig K. 

Svensson, Formation and uptake of arylhydroxylamine-haptenated 

proteins in human dendritic cells, Drug Metab. Dispos, 

35, 676-681 (2007). 

Farah D. Khan, Piyush M. Vyas, Anthony A. Gaspari and 

Craig K. Svensson, Effect of arylhydroxylamine metabolites 

of sulfamethoxazole and dapsone on stress signal expression 

in human keratinocytes, J. Pharmacol. Exp. Ther, 323, 771- 

777 (2007). 

Craig K. Svensson and Jean-Michel Scherrmann, Current 

advances and future directions for CNS delivery, AAPS Journal, 

10, 587-588 (2008). 

Craig K. Svensson, Drug Eruptions, Clinical and Basic Immunodermatology, 

263-276 (2008). 

Sree D. Panuganti and Craig K. Svensson, Drug clearance, 

Preclin. Dev. Handb.: ADME Biopharm. Prop, 715-742 

(2008). 

WATTS, VAL J. (b.1966) Associate Professor. B.S, 

1990, Ohio Northern University; Ph.D, 1994, University 

of North Carolina. NARSAD Young Investigator, NIH 

Training Fellowship, 1995-1998, Oregone Health and 

Science University. Neuroscience; Pharmacology. D2 

dopamine receptor signaling, selective modulators of D1 

and D5 dopamine receptors, G proteins, Dexras1, PKC 

modulation of adenylyl cyclases, RGS proteins, heterologous 

sensitization of recombinant adenylyl cyclases, behavioral 

sensitization. TEL: (765) 496-3872 FAX: (765) 

494-1414 

Web: people.pharmacy.purdue.edu/~vwatts/ 

Email: wattsv@pharmacy.purdue.edu 

V. J. Watts, Adenylyl cyclase isoforms as novel therapeutic 

targets: an exciting example of excitotoxicity neuroprotection, 

Mol. Interventions, 7, 70-73 (2007). 

J. A. Chester and V. J. Watts, Adenylyl cyclase 5: A new 

clue in the search for the “fountain of youth‘?, Sci STKE, 

pe64 (2007). 

P. A. Vidi, J. Chen, J. M. K. Irudayaraj and V. J. Watts, 

Adenosine A2A receptors assemble into higher-order oligomers 

at the plasma membrane, FEBS Letters, 582, 3985- 

3990 (2008). 

F. S. Willard, Z. Zheng, J. Guo, G. J. Digby, A. J. Kimple, 

J. M. Conley, C. A. Johnston, D. Bosch, M. D. Willard, V. J. 

Watts, K. A. Lambert, S. R. Ikeda, Q. Du and D. P. Siderovski, 

A point mutation to Galphai selectively blocks GoLoco 

motif binding: Direct evidence for Galpha.GoLoco complexes 

in mitotic spindle dynamics, J. Biol. Chem, 283, 

36698-36710 (2008). 

P. A. Vidi, B. R. Chemel, C.-D. Hu and V. J. Watts, Ligand-dependent 

oligomerization of dopamine D2 and adenosine 

A2A receptors in living neuronal cells, Mol. Pharmacol, 

74, 544-551 (2008). 

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