Your Daily Poison - Pesticide Action Network UK

APPENDIX 9
Lethal dose data, human and animal: inter- and intraspecies
variability (see page 15)
Results from all studies held by the Pesticides Safety Directorate are listed.
Active
substance
48
Regulatory
status
NOAEL*
(mg/kgbw/
d)
ADI(mg/
kgbw/d)
ArfD (mg/
kgbw/d)
Human leathal
dose (LD LO )
Rat (LD 50 ) Mouse
(LD 50 )
Aldicarb Essential uses 0.025 0.0025 0.0025 N/A 0.84 (M)
0.93 (M)
0.67-1.23 (M)
0.62-1.07 (F)
0.5 (M)
Atrazine Essential uses 0.5 0.005 - N/A 1869
3090
3125 (M)
10000
>6400
>6400
>15000
Chlorothalonil Annex 1 1.5 0.015 0.015 N/A >10000
>5000
>5000
Chorpyrifos Annex 1 1 0.01 0.1 N/A 163 (M) 135 (F)
169 (F) 276 (M)
350 (F) 134264 (M)
141 (F) 475 (M)
337 (F) 221 (M)
144 (F) 205 (M)
96 (F) 248 (M)
97 (F) 270 (M)
174 (F)
Diuron Undecided 1.7 (LOAEL) 0.007 0.016 N/A 4150 (F) 5000 (M)
>5000 (M)
3000-5000 (M)
>5000 (M)
4138 (M)
>2000
1182 (F)
1258 (M)
2390
437
1017
Lambdacyhalothrin
Annex 1 0.5 0.005 0.0075 56 (M) 79 (F)
632 (M) 696 (F)
0.382 (M) 1.3
3992
>1332 (M)
>5000
102
(M)152
(F)109
Rabbit
(LD 50 )
Dog
(LD 50 )
>8000 >8000
>5000
Linuron Annex 1 1.3 (LOAEL) 0.003 0.03 N/A 4000-4500
1000-4500
1146 (M)* 1508 (F)*
2120 young
2400 500
Paraquat Annex 1 0.45 0.004 0.005 The LD LO of
paraquat is
variously
reported in the
scientific
literature to be
>20-30 mg/kg
bw and ~35
mg/kg bw.
344 (M) 283 (F)
Simazine Essential uses 0.5 0.005 - N/A >10000>5000>2000
LD 50 = the theoretical lethal dose for 50 per cent of a group of animals
NOAEL = No adverse effect level
LOAEL = Lowest observed adverse effect level
(M) = male
(F) = Female
19.9
1000-
2000
LD LO = estimated human lethal dose
mg/kgbw/day = migrograms per kilogram of body weight per day
Your daily poison