Smooth Muscle Cells in Atherosclerosis Originate - Arteriosclerosis ...

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Supplementary Figure I Supplementary Figure I. Not a single plaque SMC derived from donor bone marrow cells administered at bone marrow transplantation was found. Two high power fields of an aortic root plaque from an eGFP + apoE -/- BM → apoE -/- transplanted mouse (32 weeks of age) are shown. All SMαA + cells are eGFP + . Color channels are shown separately [SMαA in (a,d), eGFP in (b,e) and combined (c,f)] to facilitate interpretation. L. Lumen. C. Fibrous cap. F. Foam cells. M. Tunica media. Red, SMαA. Green, eGFP. Greyscale, differential interference contrast. Scale bar 50 μm. Downloaded from http://atvb.ahajournals.org/ by guest on June 4, 2013
Supplementary Figure II Supplementary Figure II. Collar-induced atherosclerosis in transplanted common carotid artery (CCA) segments is pathoanatomically reminiscent of spontaneously developed atherosclerosis in apoE -/- mice. In this figure the occurrence of foam cells is shown in an eGFP + apoE -/- CCA graft anastomosed into an apoE -/- recipient mouse. As expected, foam cells in the plaque are derived from the circulation (eGFP - ) and positive for the macrophage marker Mac2. Red, Mac2. Green, eGFP. L, lumen, C. fibrous cap. F, foam cells. Scale bar 50 μm. Downloaded from http://atvb.ahajournals.org/ by guest on June 4, 2013
Page 1 and 2: Smooth Muscle Cells in Atherosclero
Page 3 and 4: BM as performed in that experiment
Page 5 and 6: plaques from the control apoE / and
Page 7 and 8: The finding of intimal SMCs that do
Page 9 and 10: Supplementary Methods Transgenic mi
Page 11 and 12: and immersion-fixed for 6 hours at
Page 13: Supplementary Table I. Plasma lipid

Smooth Muscle Cells in Atherosclerosis Originate - Arteriosclerosis ...

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