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Laboratory program and seminars Fall Semester Week 1. Introduction, safety rules Week 2. Acid-base titrations I. Factorization, titration of NaOH Week 3. Acid-base titrations II., Titration of strong and weak acids. Week 4. Acid-base titrations III., Titration curves. Week 5. Consultation/seminar, preparation for the first midterm exam. Week 6. Midterm exam I. Week 7. Titration based on redoxi reactions (Permanganometry, iodometry) Week 8. Titration based on complex formation.* Week 9. Spectrophotometry. Determination of pKa of phenol red Week 10. Electrochemistry. Week 11. Conductometry. Determination of the ionization constant of acetic acid. Week 12. Consultation. Preparation for the second midterm exam. Week.13. Midterm exam II. Week 14. Titration based on precipitation. Laboratory exam (written) Teaching Secretary Dr. András Hrabák Tel.: (+36-1) 4591500/ext. 60181 Student Affairs Secretary Mr. Zsolt Ozsváth Tel: 4591500/ext. 60061 Lab coordinator Dr. Gergely Keszler Lab Staff Mrs Mária Kövecses Mrs Márta Stroe Mrs Kinga Pelczer SEMMELWEIS UNIVERSITY / FACULTY OF MEDICINE Laboratory programs are on the 1 st floor, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, “D” passage. Faculty of Medicine 87
SEMMELWEIS UNIVERSITY / FACULTY OF MEDICINE 88 MEDICAL BIOCHEMISTRY, MOLECULAR AND CELL BIOLOGY I. Second (Spring) Semester Week Topics of the lectures Amino acids. Amino acids as electrolytes. Structure and chirality of amino acids. Reactions of amino 1 acids. Proteins. The peptide bond. Structure levels in proteins. Primary structure of proteins. 2 Steric structure of globular proteins. Conformation of proteins. Purification of proteins. Structural characteristics of fibrous proteins. Collagen. 3 Myoglobin and hemoglobin. Enzymes. Enzymes as proteins, enzyme activity. Isoenzymes. Coenzymes. 4 Enzyme kinetics. Mechanism of action of some important enzymes (serine proteases). Reversible and irreversible inhibitions of enzymes. Regulation of enzyme activity. Allosteric enzymes. 5 6 7 8 9 10 11 12 13 14 Compartmentation in the eukaryotic cells. Membrane structure. Intracellular membranes. Cell nucleus. Movement of cellular organelles. Cytoskeleton, microfilaments, microtubuli, actomyosin. Mechanism of vesicular transport. Metabolism and transport, the principle of metabolom. Metabolic profile of various organelles (endoplasmic retikulum, peroxisomes, lysosomes, mitochondria). Nucleic acids – structure and function. Bases, nucleosides, nucleotides, DNA structure, DNA denaturation, hybridization. DNA replication. Replication in procaryotes, leading and lagging strand. Okazaki fragments. DNA-dependent DNA polymerases. DNA ligase. Telomerase. topoizomerases. Replication in eucaryotes. Structure of eucaryotic chromosomes. Mitochondrial DNA. Nucleosome structure. DNA repair. Types of DNA damages; mutations, frame shift, nonsense mutations, mismatch repair. Coordination of repair and replication. Transcription in procaryotes. Structure of RNA; t-RNA, r-RNA, m-RNA, differences between the procaryotic and eucaryotic genomes. Transcription complexes, initiation, elongation, termination in procaryotes. Transcription in eucaryotes, RNA polymerases, promoters, enhancers silencers. Processing of mRNA, mechanism of splicing. Alternative splicing. The genetic code. Activation of tRNA. Mechanism of translation, initiation, elongation, termination. Antibiotics. Posttranslation modifications. Protein transport into intracellular compartments. Proteolysis. Regulation of gene expression in procaryotes. Operon model. Positive and negative regulation in the lac operon. Regulation of gene expression in procaryotes at transcrytikon level. Role of chromatine structure. DNS metilation. Enhancer sequences. Post-transcriptional regulation in eucaryotes. Regulation by the lifetime of mRNA. Translational regulation. Cell cycle in eucaryotes. Cyclins and cyclin dependent protein kinases. Proteases in the cell cycle. Regulation of G0/G1, G1/S and G2/M transitions. Integration of the repair into the cell cycle. The role of apoptosis in the cellular homeostasis. The apoptotic cell. Biochemical processes during apoptosis: role of mitochondria, activation of caspases, degradation of DNA. Molecular biology of malignant tumors. Protooncogenes and cellular oncogenes. Tumor induction by retroviruses. Possible mechanisms of the activation of oncogenes. Anti-oncogens and their roles. Oncogenic effect of DNA viruses. Relationship between cell cycle and oncogenesis. Principles of gene technology. Cloning, genomic and cDNA libraries. Blotting techniques and their utilizations. PCR and its utilization in molecular biology. Vectors and endonucleases in the gene manipulation. Synthesis of recombinant proteins. Expression of transgenes in mammalian cells. Transgenic, „knock out” animals in medical research. The Human Genome Project and its results. The DNA chip. Human gene therapy. Utilization of informatical methods in biological and medical research.
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C A L E N D A R SEMMELWEIS UNIVERSI
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Contents Government of the Universi
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SEMMELWEIS UNIVERSITY
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SEMMELWEIS UNIVERSITY 8 Faculty of
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SEMMELWEIS UNIVERSITY 10 Last day o
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SEMMELWEIS UNIVERSITY 12 previous g
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SEMMELWEIS UNIVERSITY 14 c) use the
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SEMMELWEIS UNIVERSITY 16 curriculum
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SEMMELWEIS UNIVERSITY 18 8. A subje
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SEMMELWEIS UNIVERSITY 20 one-week t
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SEMMELWEIS UNIVERSITY 22 University
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SEMMELWEIS UNIVERSITY 24 - second:
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SEMMELWEIS UNIVERSITY In case of a
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SEMMELWEIS UNIVERSITY 28 Act, Secti
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SEMMELWEIS UNIVERSITY 30 Act, Secti
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SEMMELWEIS UNIVERSITY 32 (2) The di
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SEMMELWEIS UNIVERSITY 34 (3) When t
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138 SEMMELWEIS UNIVERSITY / FACULTY
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140 SEMMELWEIS UNIVERSITY / FACULTY
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15. Tumors of childhood. 16. Tumors
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38. Etiology of cirrhosis.Primary b
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1. Prerequisites: Not more than 2 a
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ecord. Since there is no possibilit
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O60 %:1 61-70 %: 2 71-80 %: 3 81-90
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Tutors Group 1 Dr. Attila KOVÁCS /
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The common medical syndromes demons
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MEDICAL PSYCHOLOGY General Medicine
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MEDICAL ETHICS (BIOETHICS) Institut
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SEMMELWEIS UNIVERSITY / FACULTY OF
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PHARMACOLOGY AND PHARMACOTHERAPY Tu
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Requirement and attendance Requirem
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5. Introduction to human genetics (
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OBLIGATORY ELECTIVE AND ELECTIVE SU
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CLINICAL MODULE Faculty of Medicine
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Fourth Year 8th semester Subject co
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Sign up for the exam: Registration
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PUBLIC HEALTH Institute: Department
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CARDIOLOGY Tutor: Dr. György Bárc
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Title of the lecture Introduction.
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OTORHINOLARYNGOLOGY, HEAD AND NECK
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The goal of the training: a. Knowle
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and therapy of the functional scoli
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Practices Demonstration of imaging
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CLINICAL MODULE Faculty of Medicine
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Fifth Year 10th semester Subject co
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INTERNAL MEDICINE V. (1st Dept. of
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OBSTETRICS AND GYNECOLOGY Tutors: 1
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Nutrition of Infants Nutrition of T
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Second Semester Lectures Child and
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Second Semester Forensic examinatio
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...pregnancy ...morbid obesity ...r
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TRAUMATOLOGY Department of Traumato
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Absence from the exam: We can only
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NEUROLOGY General information Tutor
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11. Examination of polyneuropathies
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EMERGENCY MEDICINE - OXIOLOGY Dept.
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PREHOSPITAL AND EMERGENCY MEDICINE
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infections, urinary tract and intra
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VALUE OF ULTRASONOGRAPHY IN THE CLI
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Diseases of amino acid metabolism H
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EMERGENCY IN SURGERY Course Directo
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hospitals, but in dentist and docto
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Requirement: Participation at the l
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Justification for non-attendance at
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9. Parasomnias 10. Sleep-related br
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INFLAMMATION BIOLOGY Department of
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CHEMOTAXIS - its significance in bi
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NEUROSURGERY - Introduction to neur
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Social media in medicine Institute
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OBLIGATORY ELECTIVE AND ELECTIVE SU
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Faculty of Medicine 6 th year
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Pediatrics 1 st Department of Pedia
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INTERNAL MEDICINE - To be present f
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TRAUMATOLOGY Department of Traumato
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Exam registration: Neptun program M
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- Abnormal labor - breech delivery,
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A. Lumbar puncture (investigation o
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Neurology Examination Question List
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26. Craniocervical developmental ma
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5. Case reports should not include
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The certification of the practice s
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BASIC MODULE Faculty of Dentistry 2
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LIST OF TEXTBOOKS 1 Textbook: Berne
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Week Lecture Dissecting room Histol
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Week 9. 10. 11. 12. (Competition 1s
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Measuring ion transport across frog
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ODONTOTECHNOLOGY Dental Technology
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prepared 3-unit bridges and single
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ELECTIVE SUBJECT FOR Dentistry 2 nd
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PRE-CLINICAL MODULE Faculty of Dent
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ELECTIVE SEMMELWEIS UNIVERSITY / FA
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Lectures (2 hours per week) Practic
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PATHOLOGY 1 st Department of Pathol
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GENERAL AND ORAL MICROBIOLOGY Depar
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CONSERVATIVE DENTISTRY AND ENDODONT
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PREVENTIVE DENTISTRY II Department
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Stages of constructing complex dent
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Odontotechnology and Prostodontics
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ORAL AND MAXILLOFACIAL SURGERY Tuto
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Practices (1 hour per week) Measure
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CLINICAL MODULE Faculty of Dentistr
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LIST OF TEXTBOOKS 1 Katzung,B.: Bas
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PHARMACOLOGY, TOXICOLOGY Second Sem
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INTERNAL MEDICINE Second Semester L
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Treatment of cervical lesion Clinic
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Surgery of the liver, pancreas and
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ORTHODONTICS PRE-CLINICAL First sem
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findings can be brought home, for p
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GENERAL AND DENTAL RADIOLOGY Depart
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Bedside practice, patient demonstra
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Lectures (1,5 hours per week) Pract
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DENTAL ETHICS First Semester Bioeth
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9. week (Lecture) Justice in Health
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Textbook: Conrad Fischer—Caterina
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GNATHOLOGY - lectures and practices
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CLINICAL MODULE Faculty of Dentistr
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10th semester subjects code subject
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OTORHINOLARYNGOLOGY AND HEAD AND NE
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CONSERVATIVE DENTISTRY Tutor: Dr. K
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PEDODONTICS Department of Orthodont
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ORTHODONTICS Second Semester Week L
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ORAL MEDICINE Head of department: P
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DERMATOLOGY Lecturer: Prof. Dr. Má
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Practical guide (0,5 hour/week) Ana
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8. Dehypnosis, posthypnotic evaluat
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FACULTY OF PHARMACY Faculty of Phar
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2 nd semester Subjects Lectures Pra
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MATHEMATICS University Pharmacy, De
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Definition of a function. General a
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BIOPHYSICS Tutor: Dr. Károly Módo
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PRACTICAL GENERAL AND INORGANIC CHE
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Weeks Introduction Chemistry of coo
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6 Lipid metabolism. Fatty acid poly
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Week Lectures (2 hours per week) 10
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INTRODUCTION TO HEALTH INFORMATICS
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Faculty of Pharmacy 2 nd year
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4 th semester Subjects Lectures Pra
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QUANTITATIVE ANALYTICAL CHEMISTRY T
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Lectures (2 hours per week) Practic
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ORGANIC CHEMISTRY Second Semester W
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Week Lectures (4 hours per week) 13
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PHARMACEUTICAL BOTANY Department of
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Lectures (3 hours per week) Betaoxi
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Faculty of Pharmacy 5 th year
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* COMPULSORY PRACTICAL TRAINING AND
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Basic concepts and importance of th
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How to communicate the bad news to
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SOCIOLOGY (14 hours) Course objecti
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First semester Program: Lectures: S
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PHYTOTHERAPY Institute of Pharmacog
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4. Sequence determination of natura
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PHYSICAL ORGANIC CHEMISTRY Institut
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Pharmaceutical Compounding Departme
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EVALUATION OF PROGRESS Grading syst
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DIPLOMA WORK (Thesis) 1. In all kin
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GENERAL BOARD EXAMINATION - GBE (Co
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COST OF THE PROGRAM FOR TWO SEMESTE
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STUDENT SERVICES CENTER College Int
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REDUCTION OF TUITION FEE 1. Student
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HOW TO GET A CERTIFICATE WHICH PROV
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SAMPLE APPLICATION FORM IN ENGLISH
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EXTRA CURRICULAR FEES 1. First reta
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EXTRA CURRICULAR FEES AFTER GRADUAT
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Summary of the most important infor
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Registering for, but failing to att
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How can I log on to www.sote.hu and
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FACULTY OF HEALTH SCIENCES Faculty
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Government, Dean’s Office, Staff
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Department for Epidemiology Head of
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Training levels, obtainable degrees
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- select and apply models of nursin
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Level of qualification BSc (Bachelo
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SCHOOL OF PH.D. STUDIES School of P
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SEMMELWEIS UNIVERSITY / SCHOOL OF P
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Members of the Doctoral Council Dr.
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II. CLINICAL MEDICINE Chairman: Pro
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VIII. PATHOLOGICAL SCIENCES Chairma
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