semmelweis university 2 0 1 2 / 2 0 1 3

SEMMELWEIS UNIVERSITY / FACULTY OF PHARMACY
474
HEALTH INFORMATICS
Institute of Health Informatics Development and Further Training
Tutor: Mariann Dr. Dinyane - Szabo (dinyane.mariann@public.semmelweis-univ.hu)
Credit: 2
2 hours/week
THEMES
Introduction to usage of SAS program. Command of Edit menu in the SAS program: file
1-2. menu, edit menu, view menu, data menu, transform menu, graphs menu, utilities menu,
help menu
3. Biostatistics principles: descriptive statistics, hypothesis theorem, CI intervals.
4. Case study of descriptive statistics
5. ANOVA models: Student’s test, one way and multiple-way ANOVA designs
6. Case study of ANOVA
7. Regression analysis: correlation coefficient, one and multiple variable regression models
8. Case study of regression analysis
9. Nonparametrics methods : khi-square, Fisher’s exact test, associations.
10. Case study of nonparametrics models
11. Logistic model
12. Case study of logistic models
13. Taxonomy: clusters, factorial analysis
14. Final test: solution of a data processing problem
BIOORGANIC CHEMISTRY
Institute of Organic Chemistry
Organic compounds are produced by nature in inexhaustible richness. One of the basic sources of
therapeutically useful compounds is the molecular storage of the pharmacy of nature. Natural
products are generally environment friendly. Their chemistry is in rapid development in our days, too.
What are the most important steps of molecular evolution in the cosmos and on our Earth? What
is the origin of the chirality of life? How can natural products be isolated from the sources? How
can their structure be elucidated? How can the ingenious synthetic methods of nature be imitated
in laboratory? How can the chirality of natural products be transferred to synthetic drug molecules?
How can the complete base sequence of the human genom be determined? These are some
questions of the many others, which are tried to be answered in the special collegium.
Programme
1. Isolation of natural products (e.g. iridioids, peptides).
2. Structure elucidation of natural products.
3. Application of NMR spectroscopy for the stereostructure of organic micromolecules
(e.g. alkaloids, iridoids).