semmelweis university 2 0 1 2 / 2 0 1 3

SEMMELWEIS UNIVERSITY / FACULTY OF PHARMACY
440
Practice (2 hours per week)
Association colloids
Determination of critical micelle formation concentration by conductometric titration.
Solubilization of organic acids, determination of solubilization saturation.
Macromolecular colloids
Determination of the relative molecular mass of polymers by viscosity measurements.
Dependence of the viscosity of polyelectrolyte solutions on pH.
Phase states and structures of polymers
Determination of the thermomechanical curve of a polymer by Höppler consistometer.
Determination of the relative deformation of a polymer at various loading times.
PHYSIOLOGY
Institute of Human Physiology and Clinical Experimental Research
Tutor: Dr. Tamás Ivanics
First Semester
Week
Lecture (5 hours per week)
1 Historic overview, concepts of physiological control, homeostasis. Basics in cell
physiology. Cell-to-cell interactions. Cellular membranes and transmembrane transport.
Membrane receptors. Ionic equilibria and resting membrane potentials, ion channels and
gates. Action potentials, synaptic transmission.
2 Muscle. Contractile mechanism. Skeletal, cardiac, and smooth muscles. Biomechanics,
electrical properties, metabolism.
3 Physiology of blood circulation. Introduction. Functional organization of the cardiovascular
system, basic principles and conditions of its healthy functioning. Dynamics of blood and
Iymph flow: Physiological functions of the blood vessels, their significance in the healthy
functioning of the organism. Principles of hemodynamics. Rheology of blood.
4 Biomechanical properties of the vessel waII. Significance of vessel geometry. Signal
transduction in the blood vessels. Pressure & flow in large vessels. Circulatory resistance.
Measurement of pressure, flow and cardiac output. Factors influencing blood pressure.
Venous circulation.
5 Cardiac functions: Biomechanical basis of cardiac functions. Cardiac pump. Signal
transduction in the cardiomyocytes.
6 Cardiac cycle. Electrical activity of the heart. Transmembrane potentials. Conduction in
cardiac fibers, cardiac excitability, cardiac rhythmicity, electrocardiography.
7 Microcircuiation. Tissue oxygenization. Fluid movement across the capillary waII. Control of
lymphatic flow and interstitial fluid volume.
8 Cardiovascular control mechanisms: Systemic control mechanisms. Local control
mechanisms. Control of cardiac output.
9 Circulation through organs and special regions: Coronary circulation. Circulation of blood
and cerebrospinal fluid in the brain. The blood-brain barrier. Regulation of cerebral
circulation. Brain metabolism & oxygen requirements.
10 Splanchnic circulation. Circulation through skeletal muscles. Circulation of the skin.
Thermoregulation. Placental & fetal circulation. Physiological aspects of circulatory shock.