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SEMMELWEIS UNIVERSITY / FACULTY OF PHARMACY<br />

434<br />

PHARMACEUTICAL CHEMISTRY<br />

Second Semester<br />

Week Lectures (4 hours per week) Practicals (5 hours per week)<br />

1 Protonspeciation of drugs Equipping, identification<br />

2<br />

Determination of protonation constants<br />

Optimization of pH-dependent processes<br />

Cardiac glycosides, sugars<br />

Analysis of cardiac glycosides, sugars<br />

Drugs acting on the vegetative nervous<br />

system I.<br />

Drugs acting on the vegetative nervous<br />

system II.<br />

3<br />

4 Local anaesthetics Local anaesthetics<br />

5<br />

Cardiovascular drugs: antiarrhythmic agents<br />

Cardiovascular drugs: antianginal agents<br />

Digitalis glycosides, sugars<br />

6<br />

Cardiovascular drugs: antilipaemic agents<br />

Cardiovascular drugs: antihypertensive agents<br />

Determination of protonation<br />

macroconstants<br />

7 Diuretics Determination of protonation microconstants<br />

8 Vitamines Determination of logP<br />

9<br />

Quality assurrance, GLP, validation<br />

Non-steroid antiinflammatory agents<br />

Diuretics<br />

10<br />

Corticosteroids<br />

Sexual hormones<br />

Steroidal hormones<br />

11<br />

NMR:??phenomena<br />

NMR:??d, J, T1, T2<br />

Complete pharmacopoeial qualification of an<br />

organic compound official in Ph. Eur.<br />

12<br />

NMR:??multiplicity, 1D NMR<br />

NMR:??spin echo, 2D NMR, MRI, MRS<br />

Non-steroidal antiinflammatory agents<br />

13<br />

Desinfectants<br />

Chemotherapeutic agents: sulfonamides<br />

Chemotherapeutic agents: antimalarial drugs,<br />

Quality assurance, GLP, validation I.<br />

14 fluoroquinolones<br />

Antidiabetics<br />

Quality assurance, GLP, validation II.

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