semmelweis university 2 0 1 2 / 2 0 1 3

242
SEMMELWEIS UNIVERSITY / FACULTY OF MEDICINE
8. Epigenetic effects; genome imprinting.
9. Causes of male infertility. Y chromosome mutations and ICSI.
10. Importance of Y chromosomal and mitochondrial polymorphisms in population genetics
11. Influence of sex on heredity
12. Aggressivity and sex
13. Genetics of sexual orientation
14. Ecology and sex; role of endocrine disruptors
Attendance of a minimum of 75% of the lessons is necessary for the end-term signature. No
possibility to make up of absences.
Exam: no midterms, practice grade
Core texts: Chapters from Strachan & Read: Human Molecular Genetics 2nd Ed. and Gilbert:
Developmental Biology 8th Ed. Both are downloadable from Pubmed Bookshelf.
Lecture presentations and additional texts are available on the homepage: www.dgci.sote.hu
EPIGENETICS
Department of Genetics, Cell and Immunobiology
Course directors: Dr. Sára Tóth, Prof. Dr. András Falus
Credits: 2
First Semester
Lectures (2 hours per week):
1. Timeline of epigenetics; levels of epigenetic changes; targets of epigenetics
2. DNA methylation; de novo and maintenance methylation; Dnmt interactions
3. Histone modifications; histone code; histone modifying enzymes
4. Polycomb and trithorax complexes; Methylated DNA binding proteins
5. Transposons, and non-coding RNAs in epigenetic regulation; RNAi
6. Genome imprinting; skewed X inactivation their connection to DNA methylation
7. Epigenetic changes during early development and gametogenesis;
Epigenetic consequences of cloning and ART
8. Transgenerational epigenetics; epigenetics of endocrine disruptors;
meternal behaviour and its epigenetic consequences
9. Paramutation, transvection and mitotic bookmarking
10. Role of epigenetics in carcinogenesis; epigenetic therapy in cancer
11. Epigenetics in aging and autoimmunity
12. Epigenetic changes in diseases of the central nervous system
13. Methods used for the detection and analysis of epigenetic alterations.
Important notes:
Only for third and upper year students. There are no midterm exams. Attandance of 75% of
lectures is necessary for the end-term signature. Exam: Written or oral exam (depending on the
number of students).
No possibility to make up of absences.
Core texts: CSHL Epigenetics textbook 2006. Downloadable from
http://www-nmr.cabm.rutgers.edu/academics/biochem694/reading/Allisetal_2006.pdf
Lecture presentations and additional texts are available on the homepage: www.dgci.sote.hu