semmelweis university 2 0 1 2 / 2 0 1 3

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SEMMELWEIS UNIVERSITY / FACULTY OF MEDICINE
Important notes: No possibility to make up of absences.
There are no mid-term exams.
Attendance of 75% of lectures is neccessary for the end-term signature.
Requirement: practice grade based on the result of the written or oral exam.
(depending on the number of students).
Core text:
Alberts et al.: Essential Cell Biology. (second edition) Garland Publ. Inc. 2004.
Optional text:
Alberts et al.: Molecular Biology of the Cell. (4 th ot 5 th edition)
Lecture presentations and additional texts are available on the homepage: www.dgci.sote.hu
2. GENETICS AND GENOMICS
Department of Genetics, Cell- and Immunobiology
Lecturer: Prof. Dr. András Falus
Second semester
Lecture: 2 hours per week
Practice: 2 hour per week
Credit: 4
Purpose and aim: Genetics and genomic course is an introduction to classical, molecular
genetics and functional genomics. Topics include the types and rules of human inheritance,
structure and organization of human genom and the methods applied in theoretical and clinical
medicine, too. The mechanisms and different forms of genetic and epigenetic variations and their
effect on human health are also discussed. In some selected cases the pathway from a gene to
the manifestation of a disease phenotype is analyzed by the help of system biology approach.
Thematics:
Lectures:
1. Introduction to human genetics
2. Cell cycle, mitosis and meiosis
3. Mutations and polymorphisms
4. Cytogenetics
5. Epigenetics
6-7. Genetics of biological processes I-II.
8. Mendelien inheritance: Autosomal inheritance
9. Role of sex in inheritance
10. Population and evolution genetics
11. Human genom, comparative genomics
12. Relationship of of genom and environment; complex inheritance
13. Pharmacogenetics and pharmacogenomics
14. Social, ethical and legal aspects of human genetics
Practices:
1-2. Cell cycle and cell divisions
3-4. Cytogenetics I-II.