semmelweis university 2 0 1 2 / 2 0 1 3

MEDICAL BIOCHEMISTRY, MOLECULAR AND CELL BIOLOGY III.
Teaching secretary: István Léránt Ph.D.
Spring semester
Schedule of lectures
1. Na + ,K + ATP-ase. Structure and isoforms of Na + K + ATP-ase.
2. Cholinergic and noradrenergic neurotransmission. Molecular mechanism of exocytosis.
3.
Adrenergic receptors, dopaminerg, serotoninerg and glutamaterg neurotransmission, NO, its regulatory
role
4. Metabolism of brain
5. General properties of ion channels, K+ channels, voltage-gated, Ca 2+ -activated, and ATP-sensitive K +
channels. Voltage-gated Cl - channels. The CFTR chloride channel. Nicotinic Ach receptor.
6. Molecular and cellular elements of hemostasis, Initiation, regulation and termination of blood coagulation
7.
Initiation, regulation and termination of fibrinolysis; polymorphonuclear cells and fibrinolysis. Adhesion
molecules and platelets
8. Endothelial cells; hemostasis and cancer.
9. Pathobiochemistry of atherothrombosis and atherosclerosis. Biotransformation I.
10. Biotransformation II
11.
Hypothalamus, pituitary gland and endocrine system. Thyroid hormones. Growth factors, growth factor
receptors. Cytokines
12. Steroid hormones of adrenal cortex I.
13. Steroid hormones of adrenal cortex II, sex steroids
14. Biosynthesis and biological role of eicosanoids
Spring semester
Schedule of laboratory lessons and seminars
SEMMELWEIS UNIVERSITY / FACULTY OF MEDICINE
1. LDH isoenzymes (laboratory lesson)
2. Acute and chronic liver disease (consultation)
3. Determination of serum transaminase and creatine kinase activities (laboratory lesson)
4. Metabolism of exercise (consultation)
5. Determination of blood sugar level, glycosylated haemoglobin (laboratory lesson)
6. Cystic fibrosis (Consultation)
7. Na + ,K + – ATP-ase activity (laboratory lesson)
8. Cell adhesion molecules and signal transduction (consultation)
9. Biochemistry of haemostasis (laboratory lesson)
10. Haemostatic abnormalities (Consultation)
11. Microsomal drug metabolism (laboratory lesson)
12. Extracellular matrix – wound healing and tumor angiogenesis
13. Bioinformatics (Consultation)
14. Research of professional literature in Biochemistry. Presentation of research in our department
Faculty of Medicine
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