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Invent The Future - UC Davis Health System

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– Etiology<br />

Calcific degenerative<br />

Aortic Stenosis<br />

• Degenerative process with proliferative &<br />

inflammatory changes, lipid accumulation, up<br />

regulation ACE, infiltration with macrophages & T<br />

lymphocytes . Bone formation (vascular<br />

calcification)<br />

Congenital - Bicuspid<br />

• Turbulent flow - traumatizes leaflet<br />

fibrosis, rigidity, calcification & narrowed orifice<br />

Rheumatic<br />

• Adhesion & fusion of commissures & cusps<br />

retraction & stiffening cusps borders.<br />

• Calcific nodules both surfaces - small round or<br />

triangular opening

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