GHS Classification Guidance for the Japanese Government

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2-3-15 Organic Peroxides (1)Definitions Definitions of organic peroxides in UN GHS are as follows, and they are adopted in this guidance. 【GHS 2 nd revised edition】(2.15.1) 2.15.1.1 Organic peroxides are liquid or solid organic substances w hich contain the bivalent -0-0- structure and may be considered derivatives of hydrogen peroxide, where one or both of the hydrogen atoms have been replaced by organic radicals. The term also includes organic peroxide formulations (mixtures). Organic peroxides are thermally unstable substances or mixtures, which may undergo exothermic selfaccelerating decomposition. I n addition, they may have one or more of the following properties: (a) be liable to explosive decomposition; (b) burn rapidly; (c) be sensitive to impact or friction; (d) react dangerously with other substances. 2.15.1.2 An organic peroxide is regarded as possessing explosive properties when in laboratory testing the formulation is liable to detonate, to deflagrate rapidly or to show a violent effect when heated under confinement. (2)Classification criteria in GHS 【GHS 2 nd revised edition】(2.15.2) 2.15.2.1 Any organic peroxide shall be considered for classification in this class, unless it contains: (a) not more than 1.0% available oxygen from the organic peroxides when containing not more than 1.0% hydrogen peroxide; or (b) not more than 0.5% available oxygen from the organic peroxides when Containing more than 1.0% but not more than 7.0% hydrogen peroxide. NOTE: The available oxygen content (%) of an organic peroxide mixture is given by the formula: where: ni = number of peroxygen groups per molecule of organic peroxide i; ci = concentration (mass %) of organic peroxide i; mi = molecular mass of organic peroxide i. 2.15.2.2 Organic peroxides are classified in one of the seven categories of “Types A to G” for 82
this class, according to the following principles: (a) Any organic peroxide which, as packaged, can detonate or deflagrate rapidly will be defined as organic peroxide TYPE A; (b) Any organic peroxide possessing explosive properties and which, as packaged, neither detonates nor deflagrates rapidly, but is liable to undergo a thermal explosion in that package will be defined as organic peroxide TYPE B; (c) Any organic peroxide possessing explosive properties when the substance or mixture as packaged cannot detonate or deflagrate rapidly or undergo a thermal explosion will be defined as organic peroxide TYPE C; (d) Any organic peroxide which in laboratory testing: (i) detonates partially, does not deflagrate rapidly and shows no violent effect when heated under confinement; or (ii) does not detonate at all, deflagrates slowly and shows no violent effect when heated under confinement; or (iii) does not detonate or deflagrate at all and shows a medium effect when heated under confinement; will be defined as organic peroxide TYPE D; (e) Any organic peroxide which, in laboratory testing, neither detonates nor deflagrates at all and shows low or no effect when heated under confinement w ill be defined as organic peroxide TYPE E; (f) Any organic peroxide which, in laboratory testing, neither detonates in the cavitated state nor deflagrates at all and shows only a low or no effect when heated under confinement as well as low or no explosive power w ill be defined as organic peroxide TYPE F; (g) Any organic peroxide which, in laboratory testing, neither detonates in the cavitated state nor deflagrates at all and show s no effect when heated under confinement nor any explosive power, provided that it is thermally stable (self-accelerating decomposition temperature is 60°C or higher for a 50 kg package), and, for liquid desensitization, will be defined as organic peroxide TYPE G. If the organic peroxide desensitization, it shall be defined as organic peroxide TYPE F. NOTE 1: Type G has no hazard communication elements assigned but should be considered for properties belonging to other hazard classes. NOTE 2: Types A to G may not be necessary for all systems. 2.15.2.3 Criteria for temperature control The following organic peroxides need to be subjected to temperature control: 83
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GHS Classification Guidance for the
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2-3-12 Substances and mixtures whic
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Japanese judgments and consideratio
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(2) Points to remember when describ
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① ② Information Gathering Class
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Part2. Physical Hazards Guidance 2-
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described in the next section is of
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Information in the book can be sear
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(8) International Chemical Safety C
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guidelines can be compared with GHS
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“Liquids” are defined as substa
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When a substance does not contain c
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Table 2-2 Filled examples of "Not a
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oxygen balance = -1600 [2x +(y/2) -
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GHS classification 8)Self-reactive
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The “Dangerous Goods Regulations,
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Page 37 and 38: Table 2-5 Filled examples of “Cla
Page 39 and 40: explosion hazard: (i) combustion of
Page 41 and 42: water, by mass (n)GUANYLNITROSAMINO
Page 43 and 44: substance 0224 BARIUM AZIDE, dry or
Page 45 and 46: 1337 NITROSTARCH, WETTED with not l
Page 47 and 48: (4) Data availability Physical prop
Page 49 and 50: flame distance (ignition distance)
Page 51 and 52: Nitrogen trifluoride C і = 1.6 Nit
Page 53 and 54: 2-3-5 Gases Under Pressure (1)Defin
Page 55 and 56: 2-3-6 Flammable Liquids (1)Definiti
Page 57 and 58: Category 3 =UNRTDG3 III Category 4
Page 59 and 60: Table 2.7.1: Criteria for flammable
Page 61 and 62: 2-3-8 Self-reactive Substances and
Page 63 and 64: 2.8.2.3 Criteria for temperature co
Page 65 and 66: 3225 There is no article with a spe
Page 67 and 68: classified according to it. If not,
Page 69 and 70: classified”. Reference: UN GHS se
Page 71 and 72: Table 2.11.1: Criteria for self-hea
Page 73 and 74: than 30% water of crystallization 1
Page 75 and 76: transport, the same chemical is to
Page 77 and 78: 138: Water-reactive substances - em
Page 79 and 80: orohydrides, alkyl compounds, etc.)
Page 81 and 82: 2-3-13 Oxidizing Liquids (1)Definit
Page 83 and 84: 2-1-14 Oxidizing Solids (1)Definiti
Page 85: (Example of category 3)2067 AMMONIU
Page 89 and 90: The flow chart of 2.15.2.2 is exact
Page 91 and 92: 2-3-16 Corrosive to Metals (1)Defin
Page 93: Note: In GHS, it is defined that if
Page 96 and 97: 1-1) Organization National Institut
Page 98 and 99: URL http://www.ecetoc.org/publicati
Page 100 and 101: List 2: Useful information sources
Page 102 and 103: http://www.cdc.gov/niosh/npg/npgdrt
Page 104 and 105: 3-1-3 Management of information in
Page 106 and 107: Relation between concentration(ppm)
Page 108 and 109: follows: Category 1 (100 ppmV), Cat
Page 110 and 111: (ii) the appropriate conversion val
Page 112 and 113: UNRTDG Class 6.1 is not sub-categor
Page 114 and 115: possible” unless the obvious conc
Page 116 and 117: whereas the reference value is set
Page 118 and 119: 3-2-2 Skin Corrosion/Irritation (1)
Page 120 and 121: Table 3.2.2 Skin irritation categor
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Page 126 and 127: 【GHS 2 nd revised edition】 Figu
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Page 130 and 131: B) Classification criteria in GHS (
Page 132 and 133: (4)Guidance for classification and
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2c Structure activity Skin corrosiv
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done in parallel. This stage should
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criteria given below:” a) If ther
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[Decision Criteria 1]: In the cases
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substance shall be classified in Ca
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The classification is based on any
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7) Data from various kinds of tests
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Table 3-8 Test data as the basis of
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Category 1B. Mutagens classified a
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c)Exceptionally, strong positive re
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3-2-6 Carcinogenicity (1)Definition
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The principles of GHS classificatio
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B) Substance for which GHS classifi
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metabolic system, a cautious invest
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hazard warning for pregnant women a
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OECD414 Prenatal development toxici
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D) Decision logic and classificatio
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e considered to be sufficient. (Sub
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No. Test guideline Limit dose 414 P
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3-2-8 Specific Target Organ Toxicit
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specifically for these effects as d
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existing MSDSs. A literature search
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* Unless a description that definit
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g) When the affected organ can be i
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3-2-9 Specific Target Organ Toxicit
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Table 3-16: Guidance value ranges f
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(c) Any consistent and significant
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has received some degree of approva
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As for the classification of specif
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formed in the mouth, which then may
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The classification criteria refer t
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194
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(1)Sources for test data for Hazard
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List 2: Useful information sources
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3-3)EU classification When classif
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4-2 Classification of Hazardous to
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water solubility, and which are not
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Tests shall be conducted by using f
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e categorized based on chronic aqua
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endpoint. When it is not clear whet
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that the relevant information sourc
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214
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R39 Danger of very serious irrevers
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R52 Harmful to aquatic organisms. R
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GHS Classification Guidance for the Japanese Government

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