GHS Classification Guidance for the Japanese Government

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137: Water-reactive substances - corrosive Example: PHOSPHORUS PENTOXIDE, SULFURIC ACID 144: Oxidant (Water-reactive) SODIUM PEROXIDE 155: Toxic substances/corrosive substances (flammable/water-reactive) ACETONE CYANOHYDRIN 156: Toxic substances/corrosive substances (flammable/water-reactive) BENZYL CHLORIDE 157: Toxic substances/corrosive substances (inflammable/water-reactive) ANTIMONY TRICHLORIDE 166: Radioactive substances – corrosive (URANIUM HEXAFLUORIDE – water-reactive) These should be considered separately from “Water-reactive flammable”in GHS. (7) Discussion on GHS Water-Reactive Flammable Substances and Metalloids A)Description of UN GHS second revised edition 2.12 Section 2.12.4.2 of UN GHS second revised edition 2.12 “Substances and mixtures which, in contact with water, emit flammable gases” includes a description: “The classification procedure for this class need not be applied if the chemical structure of the substance or mixture does not contain metals or metalloids”. For smooth classification according to GHS, the definition of “metalloids” is summarized as follows: B) Metalloid A metalloid is defined as an element having an intermediate property between those of metals and nonmetals. The property is related to the electric conduction property of single element solids. In the website of Institute for Molecular Science (Okazaki Institute), National Institute of Nature Sciences, Inter-University Research Institute Corporation, B, C, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At are listed as metalloids. For example, it is presumed that carbon is classified as metalloid because it has a peculiar conductivity in the form of graphite structure. C) Water-reactive flammable substances Water-reactive flammable substances are the substances which, on contact with water, deprive it of oxygen and emit flammable gases (hydrogen, hydrocarbon, hydrogen sulfide, etc). Therefore, the category “Water-reactive flammable substances” has no direct causal relation with metalloids, which are defined based on the electric conduction property. Giving a theoretical explanation for the description of UN GHS second revised edition 2.12.4.2(a), requires the application of quite an advanced electron theory. Most of the substances listed in Class 4.3 in TDG classification, however, are actually metals or metal compounds (hydrides, phosphides, carbides, silicon compounds, 74
orohydrides, alkyl compounds, etc.), and a few metalloid compounds shown below (excluding N.O.S.) are also included in the list. UN-1183 ETHYLDICHLOROSILANE UN-1242 METHYLDICHLOROSILANE UN-1295 TRICHLOROSILANE UN-1340 PHOSPHORUS PENTASULFIDE UN-2965 BORON TRIHYDRIDE・DIMETHYL ETHER SOLUTION As substances included in Class 4.3, the following two carbon compounds (excluding metal alkylates) are listed: UN-1394 ALUMINUM CARBIDE UN-1402 CALCIUM DICARBIDE Since these substances contain a metal, they are not excluded from “water-reactive flammable substances” even if carbon is excluded from metalloids. It is presumed that the description of UN GHS second revised edition 2.12.4.2(a) intends to eliminate the discussion on classification assessment for huge amounts of organic compounds composed of only carbon, hydrogen, nitrogen, oxygen, sulfur, and four halogen elements. The aim will be lost if carbon is included in metalloids. D) Scope of the metalloid If phosphorus is interpreted to be excluded from “metalloids” defined in UN GHS second revised edition 2.12.4.2(a), phosphorus pentasulfide is excluded. Although compounds composed of selenium, tellurium and nonmetal elements are not considered to be water-reactive, they are included in the substances containing metalloids. Alternatively, it is easier to understand if the description in 2.12.4.2(a) is rephrased as follows: “The classification procedure for this class need not be applied to a substance composed of carbon, hydrogen, nitrogen, oxygen, sulfur, and one or more of four halogen elements, as well as a mixture (solid or liquid) composed of these elements only”. Nevertheless, the description of UN GHS second revised edition adopting the term “metalloids” shall be followed. If a substance or mixture falls under the exemption described in 2.12.4.2(a), fill the model classification with “Not applicable”, and fill “Grounds” with “Not containing metal or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)”. E) Assessment of inorganic metal compounds Substances and mixtures exempted from the assessment, based on UN GHS second revised edition 2.12.4.2(a), are the most part of organic compounds (except for organic metal compounds) and a part of inorganic compounds. Thus, the large majority of inorganic metal compounds remain unmentioned. With regard to them, those known to be stable in water according to UN GHS second revised edition 2.12.4.2(b) (c) shall be classified as “Not 75
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GHS Classification Guidance for the
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2-3-12 Substances and mixtures whic
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Japanese judgments and consideratio
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(2) Points to remember when describ
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① ② Information Gathering Class
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Part2. Physical Hazards Guidance 2-
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described in the next section is of
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Information in the book can be sear
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(8) International Chemical Safety C
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guidelines can be compared with GHS
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“Liquids” are defined as substa
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When a substance does not contain c
Page 27 and 28: Table 2-2 Filled examples of "Not a
Page 29 and 30: oxygen balance = -1600 [2x +(y/2) -
Page 31 and 32: GHS classification 8)Self-reactive
Page 33 and 34: The “Dangerous Goods Regulations,
Page 35 and 36: 4.2 4.3 5.1(I) 5.1(II) 5.1(III) 6.1
Page 37 and 38: Table 2-5 Filled examples of “Cla
Page 39 and 40: explosion hazard: (i) combustion of
Page 41 and 42: water, by mass (n)GUANYLNITROSAMINO
Page 43 and 44: substance 0224 BARIUM AZIDE, dry or
Page 45 and 46: 1337 NITROSTARCH, WETTED with not l
Page 47 and 48: (4) Data availability Physical prop
Page 49 and 50: flame distance (ignition distance)
Page 51 and 52: Nitrogen trifluoride C і = 1.6 Nit
Page 53 and 54: 2-3-5 Gases Under Pressure (1)Defin
Page 55 and 56: 2-3-6 Flammable Liquids (1)Definiti
Page 57 and 58: Category 3 =UNRTDG3 III Category 4
Page 59 and 60: Table 2.7.1: Criteria for flammable
Page 61 and 62: 2-3-8 Self-reactive Substances and
Page 63 and 64: 2.8.2.3 Criteria for temperature co
Page 65 and 66: 3225 There is no article with a spe
Page 67 and 68: classified according to it. If not,
Page 69 and 70: classified”. Reference: UN GHS se
Page 71 and 72: Table 2.11.1: Criteria for self-hea
Page 73 and 74: than 30% water of crystallization 1
Page 75 and 76: transport, the same chemical is to
Page 77: 138: Water-reactive substances - em
Page 81 and 82: 2-3-13 Oxidizing Liquids (1)Definit
Page 83 and 84: 2-1-14 Oxidizing Solids (1)Definiti
Page 85 and 86: (Example of category 3)2067 AMMONIU
Page 87 and 88: this class, according to the follow
Page 89 and 90: The flow chart of 2.15.2.2 is exact
Page 91 and 92: 2-3-16 Corrosive to Metals (1)Defin
Page 93: Note: In GHS, it is defined that if
Page 96 and 97: 1-1) Organization National Institut
Page 98 and 99: URL http://www.ecetoc.org/publicati
Page 100 and 101: List 2: Useful information sources
Page 102 and 103: http://www.cdc.gov/niosh/npg/npgdrt
Page 104 and 105: 3-1-3 Management of information in
Page 106 and 107: Relation between concentration(ppm)
Page 108 and 109: follows: Category 1 (100 ppmV), Cat
Page 110 and 111: (ii) the appropriate conversion val
Page 112 and 113: UNRTDG Class 6.1 is not sub-categor
Page 114 and 115: possible” unless the obvious conc
Page 116 and 117: whereas the reference value is set
Page 118 and 119: 3-2-2 Skin Corrosion/Irritation (1)
Page 120 and 121: Table 3.2.2 Skin irritation categor
Page 122 and 123: possible, and to classify the subst
Page 124 and 125: and scaling persist to the end of 1
Page 126 and 127: 【GHS 2 nd revised edition】 Figu
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[Note for the above figure] (a) Cla
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B) Classification criteria in GHS (
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(4)Guidance for classification and
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G) Strategy of testing and evaluati
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2c Structure activity Skin corrosiv
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done in parallel. This stage should
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criteria given below:” a) If ther
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[Decision Criteria 1]: In the cases
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substance shall be classified in Ca
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The classification is based on any
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7) Data from various kinds of tests
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Table 3-8 Test data as the basis of
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Category 1B. Mutagens classified a
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c)Exceptionally, strong positive re
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3-2-6 Carcinogenicity (1)Definition
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The principles of GHS classificatio
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B) Substance for which GHS classifi
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metabolic system, a cautious invest
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hazard warning for pregnant women a
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OECD414 Prenatal development toxici
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D) Decision logic and classificatio
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e considered to be sufficient. (Sub
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No. Test guideline Limit dose 414 P
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3-2-8 Specific Target Organ Toxicit
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specifically for these effects as d
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existing MSDSs. A literature search
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* Unless a description that definit
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g) When the affected organ can be i
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3-2-9 Specific Target Organ Toxicit
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Table 3-16: Guidance value ranges f
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(c) Any consistent and significant
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has received some degree of approva
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As for the classification of specif
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formed in the mouth, which then may
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The classification criteria refer t
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194
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(1)Sources for test data for Hazard
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List 2: Useful information sources
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3-3)EU classification When classif
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4-2 Classification of Hazardous to
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water solubility, and which are not
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Tests shall be conducted by using f
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e categorized based on chronic aqua
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endpoint. When it is not clear whet
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that the relevant information sourc
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214
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R39 Danger of very serious irrevers
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R52 Harmful to aquatic organisms. R
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GHS Classification Guidance for the Japanese Government

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