GHS Classification Guidance for the Japanese Government

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Examples of the functional groups are as follows: Inter-reacting group Aminonitriles, haloanilines, organic salts of oxidizing acids S=O Halogenated sulfonyl compounds, sulfonyl cyanides, sulfonyl hydrazides P–O Phosphites Strained ring Epoxides, aziridines Unsaturated bond Olefines, oxidized cyanides N–halogen Chloroamines, fluoroamines O–halogen Chlorates, perchlorates, iodosyl compounds (UNRTDG: Manual of Tests and Criteria, Appendix 6, Table A6.2) 2-2-8 Guidance for classification and examples of classification results indication This section schematically explains guidelines for classification and illustrates classification results indication for 16 types of physical hazards. When you are actually engaged in classification, please refer to items on each hazard in sections 2-3. (1) Judgment of Not applicable A) A substance the state of which is different from the definition for the relevant GHS hazard class or which does not meet the definition in terms of chemical structure, according to Table 2-1, shall be designated as “not applicable” with regard to that class. B) In case a substance meets conditions for a hazard class with higher priority: Example: A substance that should be considered as “self-reactive substances and mixtures” contains explosive or self-reacting chemical groups and is classified as “explosives”, “organic peroxides”, “oxidizing liquids”, or “oxidizing solids.” Example entry:Not applicable (classified as “explosives”) A substance that should be considered as “self-heating substances and mixtures” is classified as either “pyrophoric liquids” or “pyrophoric solids.” Example entry:not applicable (classified as “pyrophoric liquids”) Table 2-2 shows example entries for grounds for classification of substances that are judged to be “not applicable” based on A) or B). 22
Table 2-2 Filled examples of "Not applicable" Hazard class Classification result Classification Grounds and Problems 1 Explosives Not applicable Not containing chemical groups related to explosibility 3 Flammable Aerosols Not applicable Not an aerosol product 6 Flammable Liquids Not applicable “Solids” according to GHS definition 8 Self-reactive Substances and Not applicable Classified as “explosives” Mixtures Not applicable Containing neither chemical groups related to 11 Self-heating Substances and Mixtures Not applicable explosibility nor those related to self-reactivity Classified as “pyrophoric liquids” 12 Substances and Not applicable Not containing metals or semimetals (B, Si, P, Ge, As, mixtures which,in Se, Sn, Sb, Te, Bi, Po, At) contact with 13 water,emit flammable gases Oxidizing Liquids Not applicable An inorganic compound that does not contain oxygen or halogen 14 Oxidizing Solids Not applicable An organic compound that does not contain fluorine and chlorine but contains oxygen which is not bound to elements other than carbon and hydrogen 15 Organic Peroxides Not applicable An organic compound that does not contain–O–O– structure (2) Judgment of Not Classified A substance subject to classification that obviously falls under none of the relevant hazard categories according to definitions of the second revised edition of UN GHS or its well-known scientific properties (for example, “non-combustibility”) shall be classified as “not classified”. Example entries for the grounds for classification of substances judged as “not classified” are given in Table 2-3. Table 2-3 Filled examples of “Not classified” Hazard class Classification result Grounds and Example Entries 1 Explosives Not classified Not classified Based on the result of oxygen balance calculation Desensitized explosives (Title of the review document, year) 6 Flammable Liquids Not classified Non-combustibility (based on experience, name of the evaluating organization) 7 Flammable Solid Not classified Non-combustibility (Title of the review document, year) 8 Self-reactive Substances and Mixtures Not classified Enter the concrete value ( ℃ ) of self-accelerating decomposition temperature (SADT). (Title of the review document, year) 23
Page 1: GHS Classification Guidance for the
Page 4 and 5: 2-3-12 Substances and mixtures whic
Page 6 and 7: Japanese judgments and consideratio
Page 8 and 9: (2) Points to remember when describ
Page 10 and 11: ① ② Information Gathering Class
Page 13 and 14: Part2. Physical Hazards Guidance 2-
Page 15 and 16: described in the next section is of
Page 17 and 18: Information in the book can be sear
Page 19 and 20: (8) International Chemical Safety C
Page 21 and 22: guidelines can be compared with GHS
Page 23 and 24: “Liquids” are defined as substa
Page 25: When a substance does not contain c
Page 29 and 30: oxygen balance = -1600 [2x +(y/2) -
Page 31 and 32: GHS classification 8)Self-reactive
Page 33 and 34: The “Dangerous Goods Regulations,
Page 35 and 36: 4.2 4.3 5.1(I) 5.1(II) 5.1(III) 6.1
Page 37 and 38: Table 2-5 Filled examples of “Cla
Page 39 and 40: explosion hazard: (i) combustion of
Page 41 and 42: water, by mass (n)GUANYLNITROSAMINO
Page 43 and 44: substance 0224 BARIUM AZIDE, dry or
Page 45 and 46: 1337 NITROSTARCH, WETTED with not l
Page 47 and 48: (4) Data availability Physical prop
Page 49 and 50: flame distance (ignition distance)
Page 51 and 52: Nitrogen trifluoride C і = 1.6 Nit
Page 53 and 54: 2-3-5 Gases Under Pressure (1)Defin
Page 55 and 56: 2-3-6 Flammable Liquids (1)Definiti
Page 57 and 58: Category 3 =UNRTDG3 III Category 4
Page 59 and 60: Table 2.7.1: Criteria for flammable
Page 61 and 62: 2-3-8 Self-reactive Substances and
Page 63 and 64: 2.8.2.3 Criteria for temperature co
Page 65 and 66: 3225 There is no article with a spe
Page 67 and 68: classified according to it. If not,
Page 69 and 70: classified”. Reference: UN GHS se
Page 71 and 72: Table 2.11.1: Criteria for self-hea
Page 73 and 74: than 30% water of crystallization 1
Page 75 and 76: transport, the same chemical is to
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138: Water-reactive substances - em
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orohydrides, alkyl compounds, etc.)
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2-3-13 Oxidizing Liquids (1)Definit
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2-1-14 Oxidizing Solids (1)Definiti
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(Example of category 3)2067 AMMONIU
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this class, according to the follow
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The flow chart of 2.15.2.2 is exact
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2-3-16 Corrosive to Metals (1)Defin
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Note: In GHS, it is defined that if
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1-1) Organization National Institut
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URL http://www.ecetoc.org/publicati
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List 2: Useful information sources
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http://www.cdc.gov/niosh/npg/npgdrt
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3-1-3 Management of information in
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Relation between concentration(ppm)
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follows: Category 1 (100 ppmV), Cat
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(ii) the appropriate conversion val
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UNRTDG Class 6.1 is not sub-categor
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possible” unless the obvious conc
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whereas the reference value is set
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3-2-2 Skin Corrosion/Irritation (1)
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Table 3.2.2 Skin irritation categor
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possible, and to classify the subst
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and scaling persist to the end of 1
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【GHS 2 nd revised edition】 Figu
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[Note for the above figure] (a) Cla
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B) Classification criteria in GHS (
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(4)Guidance for classification and
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G) Strategy of testing and evaluati
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2c Structure activity Skin corrosiv
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done in parallel. This stage should
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criteria given below:” a) If ther
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[Decision Criteria 1]: In the cases
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substance shall be classified in Ca
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The classification is based on any
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7) Data from various kinds of tests
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Table 3-8 Test data as the basis of
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Category 1B. Mutagens classified a
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c)Exceptionally, strong positive re
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3-2-6 Carcinogenicity (1)Definition
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The principles of GHS classificatio
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B) Substance for which GHS classifi
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metabolic system, a cautious invest
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hazard warning for pregnant women a
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OECD414 Prenatal development toxici
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D) Decision logic and classificatio
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e considered to be sufficient. (Sub
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No. Test guideline Limit dose 414 P
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3-2-8 Specific Target Organ Toxicit
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specifically for these effects as d
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existing MSDSs. A literature search
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* Unless a description that definit
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g) When the affected organ can be i
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3-2-9 Specific Target Organ Toxicit
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Table 3-16: Guidance value ranges f
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(c) Any consistent and significant
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has received some degree of approva
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As for the classification of specif
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formed in the mouth, which then may
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The classification criteria refer t
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194
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(1)Sources for test data for Hazard
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List 2: Useful information sources
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3-3)EU classification When classif
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4-2 Classification of Hazardous to
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water solubility, and which are not
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Tests shall be conducted by using f
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e categorized based on chronic aqua
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endpoint. When it is not clear whet
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that the relevant information sourc
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214
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R39 Danger of very serious irrevers
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R52 Harmful to aquatic organisms. R
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GHS Classification Guidance for the Japanese Government

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