GHS Classification Guidance for the Japanese Government

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water solubility, and which are not rapidly degradable and have a log Kow ≥4, indicating a potential to bioaccumulate, will be classified in this category unless other scientific evidence exists showing classification to be unnecessary. Such evidence would include an experimentally determined BCF 1 mg/l, or evidence of rapid degradation in the environment B) Classification criteria in GHS(Reference information) The classification criteria described in the UN GHS second revised edition 4.1.2 can be summarized as follows. In the coming UN GHS third edition (which will come into force in July 2009), however, it is agreed that "Categories of chronic hazards shall be classified based on chronic hazard values. If chronic hazard values are not available, classification shall be performed by using acute toxicity categories below. " Category: Acute 1 96 hr LC50 (for fish) ≤1 mg/l and/or 48 hr EC50 (for crustacea) ≤1 mg/l and/or 72 or 96hr ErC50 (for algae or other aquatic plants) ≤1 mg/ Category: Acute 2 96 hr LC50 (for fish) >1 - ≤10 mg/l and/or 48 hr EC50 (for crustacea) >1 - ≤10 mg/l and/or 72 or 96hr ErC50 (for algae or other aquatic plants) >1 - ≤10 mg/l Category: Acute 3 96 hr LC50 (for fish) >10 -≤100 mg/L and/or 48 hr EC50 (for crustacea) >10 -≤100 mg/L and/or 72 or 96hr ErC50 (for algae or other aquatic plants) >10 -≤100 mg/L Category: Chronic 1 96 hr LC50 (for fish) ≤1 mg/l and/or 48 hr EC50 (for crustacea) ≤1 mg/l and/or 72 or 96hr ErC50 (for algae or other aquatic plants) ≤1 mg/ and the substances is not rapidly degradable and/or the log Kow ≥ 4 (unless the experimentally determined BCF is
96 hr LC50 (for fish) >1 to ≤10 mg/l and/or 48 hr EC50 (for crustacea) >1to ≤10 mg/l and/or 72 or 96hr ErC50 (for algae or other aquatic plants) >1 to ≤10 mg/l and the substance is not rapidly degradable and/or the log Kow ≥ 4 (unless the experimentally determined BCF is 1mg/L Category: Chronic 3 96 hr LC50 (for fish) >10 to ≤100 mg/L and/or 48 hr EC50 (for crustacea) >10 to ≤100 mg/L and/or 72 or 96hr ErC50 (for algae or other aquatic plants) >10 to ≤100 mg/L and the substance is not rapidly degradable and/or the log Kow ≥ 4 (unless the experimentally determined BCF is 1mg/L Category: Chronic 4 Poorly soluble substances for which no acute toxicity is recorded at levels up to the water solubility, and which are not rapidly degradable and have a log Kow ≥4, indicating a potential to bioaccumulate, will be classified in this category unless other scientific evidence exists showing classification to be unnecessary. Such evidence would include an experimentally determined BCF 1 mg/l, or evidence of rapid degradation in the environment (3)Items on information sources and data A) Data availability Most information sources (shown in 4-1) of data for classification on acute aquatic toxicity, bioconcentration (Bioconcentration factor, octanol/water partition coefficient), rapid degradability (biotic or abiotic), and chronic aquatic toxicity can be easily accessed from web sites. Broad collection of related information is important since data on stability of substances in water, water-solubilities, etc. are also used in classification. EU classification results, which are similar to GHS classification, are available as reference information. They cannot, however, be directly used in GHS classification since classification criteria for chronic aquatic toxicity in EU classification is different from that in GHS classification and since its evidence information is hard to obtain. B) Requirements for data to be collected and utilized 1) Information on hazardous to the aquatic environment; Values of acute toxicity by aquatic exposure a) Requirements for data to be collected 205
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GHS Classification Guidance for the
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2-3-12 Substances and mixtures whic
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Japanese judgments and consideratio
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(2) Points to remember when describ
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① ② Information Gathering Class
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Part2. Physical Hazards Guidance 2-
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described in the next section is of
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Information in the book can be sear
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(8) International Chemical Safety C
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guidelines can be compared with GHS
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“Liquids” are defined as substa
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When a substance does not contain c
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Table 2-2 Filled examples of "Not a
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oxygen balance = -1600 [2x +(y/2) -
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GHS classification 8)Self-reactive
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The “Dangerous Goods Regulations,
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4.2 4.3 5.1(I) 5.1(II) 5.1(III) 6.1
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Table 2-5 Filled examples of “Cla
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explosion hazard: (i) combustion of
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water, by mass (n)GUANYLNITROSAMINO
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substance 0224 BARIUM AZIDE, dry or
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1337 NITROSTARCH, WETTED with not l
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(4) Data availability Physical prop
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flame distance (ignition distance)
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Nitrogen trifluoride C і = 1.6 Nit
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2-3-5 Gases Under Pressure (1)Defin
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2-3-6 Flammable Liquids (1)Definiti
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Category 3 =UNRTDG3 III Category 4
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Table 2.7.1: Criteria for flammable
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2-3-8 Self-reactive Substances and
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2.8.2.3 Criteria for temperature co
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3225 There is no article with a spe
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classified according to it. If not,
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classified”. Reference: UN GHS se
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Table 2.11.1: Criteria for self-hea
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than 30% water of crystallization 1
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transport, the same chemical is to
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138: Water-reactive substances - em
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orohydrides, alkyl compounds, etc.)
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2-3-13 Oxidizing Liquids (1)Definit
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2-1-14 Oxidizing Solids (1)Definiti
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(Example of category 3)2067 AMMONIU
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this class, according to the follow
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The flow chart of 2.15.2.2 is exact
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2-3-16 Corrosive to Metals (1)Defin
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Note: In GHS, it is defined that if
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1-1) Organization National Institut
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URL http://www.ecetoc.org/publicati
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List 2: Useful information sources
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http://www.cdc.gov/niosh/npg/npgdrt
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3-1-3 Management of information in
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Relation between concentration(ppm)
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follows: Category 1 (100 ppmV), Cat
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(ii) the appropriate conversion val
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UNRTDG Class 6.1 is not sub-categor
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possible” unless the obvious conc
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whereas the reference value is set
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3-2-2 Skin Corrosion/Irritation (1)
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Table 3.2.2 Skin irritation categor
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possible, and to classify the subst
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and scaling persist to the end of 1
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【GHS 2 nd revised edition】 Figu
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[Note for the above figure] (a) Cla
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B) Classification criteria in GHS (
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(4)Guidance for classification and
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G) Strategy of testing and evaluati
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2c Structure activity Skin corrosiv
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done in parallel. This stage should
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criteria given below:” a) If ther
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[Decision Criteria 1]: In the cases
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substance shall be classified in Ca
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The classification is based on any
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7) Data from various kinds of tests
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Table 3-8 Test data as the basis of
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Category 1B. Mutagens classified a
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c)Exceptionally, strong positive re
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3-2-6 Carcinogenicity (1)Definition
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Page 166 and 167: OECD414 Prenatal development toxici
Page 168 and 169: D) Decision logic and classificatio
Page 170 and 171: e considered to be sufficient. (Sub
Page 172 and 173: No. Test guideline Limit dose 414 P
Page 174 and 175: 3-2-8 Specific Target Organ Toxicit
Page 176 and 177: specifically for these effects as d
Page 178 and 179: existing MSDSs. A literature search
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Page 212 and 213: e categorized based on chronic aqua
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Page 220 and 221: R39 Danger of very serious irrevers
Page 222: R52 Harmful to aquatic organisms. R
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GHS Classification Guidance for the Japanese Government

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