GHS Classification Guidance for the Japanese Government

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List 2: Useful information sources of other assessment documents than listed in List1. 2-1) Organisation AQUIRE Source Aquatic Toxicity Information Retrieval(AQUIRE) URL http://cfpub.epa.gov/ecotox/ Note Database on chemical substance and aquatic toxicity established in 1981 by EPA. It is now combined with terrestrial hazardous database, making it as Ecotox database. Japanese Version: http://www.jaici.or.jp/stn/dbsummary/db.html 2-2) Organisation EU European Chemicals Bureau (ECB) Source International Uniform Chemical Information Database (IUCLID) IUCLID CD-ROM (Update Version Edition 2 - 2000) URL http://ecb.jrc.it/esis/esis.php?PGM=hpv&DEPUIS=autre 2-3) Organisation National Library of Medicine(NLM) Source Hazardous Substance Data Bank(HSDB) URL http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB 2-4) Organisation EU European Chemicals Bureau (ECB) Source The N-CLASS Database on Environmental Hazard Classification (N-Class) URL http://www.kemi.se/nclass/ (in maintenance as of 29.Sep.2008) Note Database established in corporation of ECB and The Nordic Council of Ministers. The information on N(R50-53) of EU lists of dangerous goods can be obtained. 2-5) Organisation German Chemical Society-Advisory Committee on Existing Chemicals of Environmental Relevance Source BUA Report(BUA) URL http://www.hirzel.de/bua-report/download.html Note Full report can not be available from web site. 198
List 3: These are databases for searching and accessing primary literatures. In the case where data are available in List 1 or 2, these databases sould be referred to if appropriate. Although hazard information of an individual product is available from existing MSDSs, etc., its direct use for GHS classification should be avoided. 3-1)Database for primary literatures ● Pub-Med/NLM(For original litearture) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi ● NLM TOXNET(Online database including original literature) http://toxnet.nlm.nih.gov/index.html ● JICST (JDream II) http://pr.jst.go.jp/db/db.html 3-2)General information database on chemical substances ● National Institute of Technology and Evaluation Chemical Risk Information Platform(CHRIP):http://www.safe.nite.go.jp/japan/db.html ● Berufsgenossenschaftliches Institute for Arbeitssicherheit (BIA) “GESTIS-database on hazardous substances” (GESTIS): http://www.hvbg.de/e/bia/fac/stoffdb/index.html ● Ministry of the Environment Government:Chemical Substanes Fact Sheets http://www.env.go.jp/chemi/communication/factsheet.html ● National Institute for Environmental Studies ”WebKis-Plus Chemical Substanes Database” (WebKis-Plus):http://w-chemdb.nies.go.jp/ ● National Institute of Advanced Industrial Science and Technology “Risk Assessment Documents”:http://unit.aist.go.jp/riss/crm/mainmenu/1.html ● Chemicals Evalution and Reserch Institute,Japan(CERI) ”Chemical Substance Hazard Data”: http://www.cerij.or.jp/db/sheet/sheet_indx.htm ● Hazardous Substance Fact Sheet (New Jersey Department of Health and Senior Services): http://web.doh.state.nj.us/rtkhsfs/indexfs.aspx ● “Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens (4th edition,2002)”(Sittig) ● The National Institute for Occupational Safety and Health (NIOSH)[Registry of Toxic Effects of Chemical Substances](RTECS):http://www.cdc.gov/niosh/npg/npgdrtec.html ● WHO/IPCS “International Chemical Safety Cards” (ICSC): http://www.ilo.org/public/english/protection/safework/cis/products/icsc/dtasht/index.htm (ICSC Japanese Version:http://www.nihs.go.jp/ICSC/) 199
Page 1:
GHS Classification Guidance for the
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2-3-12 Substances and mixtures whic
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Japanese judgments and consideratio
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(2) Points to remember when describ
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① ② Information Gathering Class
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Part2. Physical Hazards Guidance 2-
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described in the next section is of
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Information in the book can be sear
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(8) International Chemical Safety C
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guidelines can be compared with GHS
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“Liquids” are defined as substa
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When a substance does not contain c
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Table 2-2 Filled examples of "Not a
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oxygen balance = -1600 [2x +(y/2) -
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GHS classification 8)Self-reactive
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The “Dangerous Goods Regulations,
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4.2 4.3 5.1(I) 5.1(II) 5.1(III) 6.1
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Table 2-5 Filled examples of “Cla
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explosion hazard: (i) combustion of
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water, by mass (n)GUANYLNITROSAMINO
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substance 0224 BARIUM AZIDE, dry or
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1337 NITROSTARCH, WETTED with not l
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(4) Data availability Physical prop
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flame distance (ignition distance)
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Nitrogen trifluoride C і = 1.6 Nit
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2-3-5 Gases Under Pressure (1)Defin
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2-3-6 Flammable Liquids (1)Definiti
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Category 3 =UNRTDG3 III Category 4
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Table 2.7.1: Criteria for flammable
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2-3-8 Self-reactive Substances and
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2.8.2.3 Criteria for temperature co
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3225 There is no article with a spe
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classified according to it. If not,
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classified”. Reference: UN GHS se
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Table 2.11.1: Criteria for self-hea
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than 30% water of crystallization 1
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transport, the same chemical is to
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138: Water-reactive substances - em
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orohydrides, alkyl compounds, etc.)
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2-3-13 Oxidizing Liquids (1)Definit
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2-1-14 Oxidizing Solids (1)Definiti
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(Example of category 3)2067 AMMONIU
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this class, according to the follow
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The flow chart of 2.15.2.2 is exact
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2-3-16 Corrosive to Metals (1)Defin
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Note: In GHS, it is defined that if
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1-1) Organization National Institut
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URL http://www.ecetoc.org/publicati
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List 2: Useful information sources
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http://www.cdc.gov/niosh/npg/npgdrt
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3-1-3 Management of information in
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Relation between concentration(ppm)
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follows: Category 1 (100 ppmV), Cat
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(ii) the appropriate conversion val
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UNRTDG Class 6.1 is not sub-categor
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possible” unless the obvious conc
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whereas the reference value is set
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3-2-2 Skin Corrosion/Irritation (1)
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Table 3.2.2 Skin irritation categor
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possible, and to classify the subst
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and scaling persist to the end of 1
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【GHS 2 nd revised edition】 Figu
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[Note for the above figure] (a) Cla
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B) Classification criteria in GHS (
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(4)Guidance for classification and
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G) Strategy of testing and evaluati
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2c Structure activity Skin corrosiv
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done in parallel. This stage should
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criteria given below:” a) If ther
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[Decision Criteria 1]: In the cases
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substance shall be classified in Ca
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The classification is based on any
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7) Data from various kinds of tests
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Table 3-8 Test data as the basis of
Page 152 and 153: Category 1B. Mutagens classified a
Page 154 and 155: c)Exceptionally, strong positive re
Page 156 and 157: 3-2-6 Carcinogenicity (1)Definition
Page 158 and 159: The principles of GHS classificatio
Page 160 and 161: B) Substance for which GHS classifi
Page 162 and 163: metabolic system, a cautious invest
Page 164 and 165: hazard warning for pregnant women a
Page 166 and 167: OECD414 Prenatal development toxici
Page 168 and 169: D) Decision logic and classificatio
Page 170 and 171: e considered to be sufficient. (Sub
Page 172 and 173: No. Test guideline Limit dose 414 P
Page 174 and 175: 3-2-8 Specific Target Organ Toxicit
Page 176 and 177: specifically for these effects as d
Page 178 and 179: existing MSDSs. A literature search
Page 180 and 181: * Unless a description that definit
Page 182 and 183: g) When the affected organ can be i
Page 184 and 185: 3-2-9 Specific Target Organ Toxicit
Page 186 and 187: Table 3-16: Guidance value ranges f
Page 188 and 189: (c) Any consistent and significant
Page 190 and 191: has received some degree of approva
Page 192 and 193: As for the classification of specif
Page 194 and 195: formed in the mouth, which then may
Page 196 and 197: The classification criteria refer t
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Page 200 and 201: (1)Sources for test data for Hazard
Page 204 and 205: 3-3)EU classification When classif
Page 206 and 207: 4-2 Classification of Hazardous to
Page 208 and 209: water solubility, and which are not
Page 210 and 211: Tests shall be conducted by using f
Page 212 and 213: e categorized based on chronic aqua
Page 214 and 215: endpoint. When it is not clear whet
Page 216 and 217: that the relevant information sourc
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Page 220 and 221: R39 Danger of very serious irrevers
Page 222: R52 Harmful to aquatic organisms. R
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GHS Classification Guidance for the Japanese Government

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