GHS Classification Guidance for the Japanese Government
GHS Classification Guidance for the Japanese Government
GHS Classification Guidance for the Japanese Government
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Category 2:Suspected human carcinogens<br />
The placing of a chemical in Category 2 is done on <strong>the</strong> basis of evidence obtained from<br />
human and/or animal studies, but which is not sufficiently convincing to place <strong>the</strong> chemical in<br />
Category 1. Based on strength of evidence toge<strong>the</strong>r with additional considerations, such<br />
evidence may be from ei<strong>the</strong>r limited evidence of carcinogenicity in human studies or from<br />
limited evidence of carcinogenicity in animal studies.<br />
<strong>Classification</strong>: Category 2 Carcinogen<br />
B) <strong>Classification</strong> criteria in <strong>GHS</strong> (Reference in<strong>for</strong>mation)<br />
In classification criteria of JIS classification and that of <strong>GHS</strong>, <strong>the</strong> same categories are<br />
adopted.<br />
(3)Items on in<strong>for</strong>mation sources and data<br />
* <strong>Classification</strong> procedure can be referred to "3-1-1 Sources of In<strong>for</strong>mation available <strong>for</strong><br />
classification".<br />
A) Data availability<br />
Many descriptions on carcinogenicity can be found in hazard-related reviews and databases.<br />
Useful rankings of carcinogenicity are reported by many organizations, which can be of<br />
reference in classification (WHO International Agency <strong>for</strong> Research on Cancer (IARC),<br />
<strong>Classification</strong> results of EU classification, <strong>the</strong> U.S. National Toxicology Program(NTP),<br />
carcinogens in “Recommendations <strong>for</strong> Acceptable Concentrations” by <strong>the</strong> Japan Society For<br />
Occupational Health, Carcinogenicity notes in “TLVs and BEIs” by ACGIH, Integrated Risk<br />
In<strong>for</strong>mation System(IRIS) by <strong>the</strong> U.S. EPA、Carcinogenicity notes in “List of MAK and<br />
BAT Values” by Germany DFG, etc. See [3-1]).<br />
OECD Test Guidelines include <strong>the</strong> following test methods relating to Carcinogenicity.<br />
OECD451 Carcinogenicity studies<br />
OECD453 Combined chronic toxicity / carcinogenicity studies<br />
B) Order of Precedence when Conflicting Data Exist<br />
By referring to “3-1-2 Order of Precedence when Conflicting Data Exist” (p.97),<strong>the</strong><br />
following points should be taken into consideration.<br />
In<strong>for</strong>mation by IARC and EU represents conclusions by many experts, and takes<br />
precedence. Besides, in<strong>for</strong>mation by <strong>the</strong> Japan Society For Occupational Health, US-EPA,<br />
US-NTP, ACGIH, and <strong>the</strong> Germany DFG, if any, can be of reference.<br />
C) Comparison with conventional classification systems<br />
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