GHS Classification Guidance for the Japanese Government
GHS Classification Guidance for the Japanese Government GHS Classification Guidance for the Japanese Government
G) Strategy of testing and evaluation for Serious Eye Damage/Eye Irritation The strategy of tiered testing and evaluation for Serious Eye Damage/Eye Irritation described in the UN GHS the second revised edition, Fig. 3.3.1 is as follows. As described in D), structure-activity relationship or structure-property relationship (Steps 2a, 2b, and 2c) is not adopted in this guidance. (Also, refer to Skin irritation/corrosion test and summary of the results.) 130
【GHS 2 nd revised edition】 Figure 3.3.1: Testing and evaluation strategy for serious eye damage and eye irritation (see also: “Testing and evaluation strategy for skin irritation/corrosion” Figure 3.2.1) Step Parameter Findings Conclusions 1a Data relating to historical Serious eye Category 1 human or animal damage experience Eye irritant Category 2 No or don’t know 1b Data relating to historical Skin corrosive No evaluation of effects human or animal on eyes; deemed to be experience Category 1 No or don’t know 1c Data relating to historical Skin irritant No evaluation of effects human or animal on eyes; deemed to be experience Category 2 No or don’t know [2a、2b and 2c are not adopted in this guidance] 2a Structure activity Severe damage to Category 1 relationships/Structure eyes property relationships (SAR/SPR) No or don’t know 2b Structure activity Eye irritant No evaluation of effects relationships/Structure on eyes; deemed to be property relationships Category 2 (SAR/SPR) No or don’t know 131
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G) Strategy of testing and evaluation <strong>for</strong> Serious Eye Damage/Eye Irritation<br />
The strategy of tiered testing and evaluation <strong>for</strong> Serious Eye Damage/Eye Irritation described<br />
in <strong>the</strong> UN <strong>GHS</strong> <strong>the</strong> second revised edition, Fig. 3.3.1 is as follows. As described in D),<br />
structure-activity relationship or structure-property relationship (Steps 2a, 2b, and 2c) is not<br />
adopted in this guidance.<br />
(Also, refer to Skin irritation/corrosion test and summary of <strong>the</strong> results.)<br />
130
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