GHS Classification Guidance for the Japanese Government

OECD405 Acute eye irritation / corrosion
B) Order of Precedence when Conflicting Data Exist
Refer to “3-1-2 Order of Precedence when Conflicting Data Exist” (p.97).
C) Comparison with conventional classification systems
Substances classified as R41 in EU classification fall under Category 1.
Substances classified in R36 and combination of R-Phrases 7 (R36/37, R36/38,
R36/37/38) in EU classification fall under Category 2.
D) Guidance concerning data
In many cases, findings of test reports are given using the evaluative scale of “severe”,
“moderate”, and “mild”, and these can be considered to correspond to Categories 1, 2A, and "B,
respectively. Depending, however, on the test method used, application conditions of test
materials, and criteria for “severe”, “moderate”, and “mild”, the extent of eye reactions may
differ. It is preferable to confirm the final findings, as well as to review the cited original
literature, and to examine its scientific validity. From the point of view, Category 1 is applied to
substances that cause irreversible effects on such as cotnea and iris within the observation
period of eye damage/ eye irritation test. A substance evaluated as “Severe” including no
irreversible effects fall under Category 2A.
Findings of test reports
GHS Category
7 For R-Phrase, see Appendix.
Corrosive Severe Moderate Mild
+irreversible
effects
Serious Eye Damage/ 1 2A 2B
Eye Irritation
127