GHS Classification Guidance for the Japanese Government

4 Existing skin data in Yes Possibly no further testing
animals indicate no need for may be deemed corrosive/
animal testing (d) irritant
No indication or no data
5 Valid and accepted in vitro Positive response Classify as corrosive (a)
skin corrosion test (e)
Negative response or no
data
6 Valid and accepted in vitro Positive response Classify as irritant (a)
skin irritation test (f)
Negative response or no
data
7 In vivo skin corrosion test Positive response Classify as corrosive (a)
(1 animal)
Negative response
8 In vivo skin irritation test Positive response Classify as irritant (a)
(3 animals total) (h)
Negative response No further testing No further testing, not
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classified
9 When it is ethical to Positive response Classify as irritant (a)
perform human patch
testing (g)
Not as above Negative response No further testing, not
classified