GHS Classification Guidance for the Japanese Government
GHS Classification Guidance for the Japanese Government GHS Classification Guidance for the Japanese Government
whereas the reference value is set in mg/L in the column of vapour inhalation of the main body of the table since a test described as conducted for “vapour” actually has “inclusion of mist” in some cases, in which cases the concentration cannot be indicated accurately unless indicated in mg/L. The values shown here are the same as the classification reference values of gas. In text 3.1.2.6.2, the same point is repeatedly described. In accordance with the gist of Note (d) of Table 3.1.1. and the text paragraph 3.1.2.6.2 of the UN GHS second revised edition, classification of acute toxicity in the case of “inhalation” is performed as follows. 1) As for gas based on the definition of GHS, the category reference values (ppmV) of gas are applied. 2) When an experiment is performed at the concentration of the saturated vapour pressure or more with the vapour generated from liquids, the substance is determined as “mists”, and the category reference values of “dusts and mists” are applied. 3) When an experiment is performed at the concentration of the saturated vapour pressure or less with the vapour generated from liquids, the substance is handled as “vapours”. When handled as "vapours", since there are cases where mists are estimated to be included and where mist is estimated to be hardly included in accordance with GHS, categorization is performed based on the following a) to d). a) When mists are estimated to be included, categorization is performed based on the reference values in the unit of mg/L shown in the row of “vapours” in the Table. b) When mist is estimated to be hardly included, categorization is performed based on the reference values (the same values as for gases) in the unit of ppmV shown in the Note (d) of Table 3.1.1 c) When the ATE(LC50)value obtained from a test is between the value for the saturated vapour pressure concentration of the substance and a value corresponding to that of the saturated vapour pressure concentration, the substance is determined as “vapour with included mists” with consideration of the possibility of mist inclusion, and 1) is applied. In case of lower concentration, the substance is determined as “vapour with hardly included mist”, and 2) is applied. d) When description in a document is in mg/L, values therein are converted into those in ppmV based on the molecular weight and temperature, and the above method is applied. If the temperature during the inhalation test is not described, the unit conversion is performed by assuming that the temperature is 25°C and the volume of gas of 1 mole is 24.45 L. 4) When it is described that a test is conducted definitely for “mists”, the substance tested is treated as mist. 5) Since it is also presumed that vapour generated from solid is inhaled, the vapour which is 112
generated from solid (other than gases/ liquids) is treated as “Vapour” when it is clearly indicated as “vapour” or the inhalation concentration is indicated in unit of ppmV. However, when a concentration is at the value of the saturated vapour pressure concentration or greater, dust may be included. Since GHS has no special definition for this case, specify as follows: “Doubtful description as vapour because the described pressure exceeds the saturated vapour pressure: high possibility of dust inclusion”. When a concentration is at the value that corresponds to the saturated vapour pressure or less, and when the unit is mg/L, and when there is no clear indication of vapour or dust, generally, classification is not possible. In this case, it is desirable to indicate specially, “Category ○○ if it is vapour, Category ○○ if it is dust”. 113
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- Page 81 and 82: 2-3-13 Oxidizing Liquids (1)Definit
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- Page 85 and 86: (Example of category 3)2067 AMMONIU
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- Page 89 and 90: The flow chart of 2.15.2.2 is exact
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- Page 93: Note: In GHS, it is defined that if
- Page 96 and 97: 1-1) Organization National Institut
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- Page 100 and 101: List 2: Useful information sources
- Page 102 and 103: http://www.cdc.gov/niosh/npg/npgdrt
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- Page 108 and 109: follows: Category 1 (100 ppmV), Cat
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- Page 112 and 113: UNRTDG Class 6.1 is not sub-categor
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- Page 118 and 119: 3-2-2 Skin Corrosion/Irritation (1)
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generated from solid (o<strong>the</strong>r than gases/ liquids) is treated as “Vapour” when it is clearly<br />
indicated as “vapour” or <strong>the</strong> inhalation concentration is indicated in unit of ppmV.<br />
However, when a concentration is at <strong>the</strong> value of <strong>the</strong> saturated vapour pressure<br />
concentration or greater, dust may be included. Since <strong>GHS</strong> has no special definition <strong>for</strong><br />
this case, specify as follows: “Doubtful description as vapour because <strong>the</strong> described<br />
pressure exceeds <strong>the</strong> saturated vapour pressure: high possibility of dust inclusion”. When a<br />
concentration is at <strong>the</strong> value that corresponds to <strong>the</strong> saturated vapour pressure or less, and<br />
when <strong>the</strong> unit is mg/L, and when <strong>the</strong>re is no clear indication of vapour or dust, generally,<br />
classification is not possible. In this case, it is desirable to indicate specially, “Category ○○<br />
if it is vapour, Category ○○ if it is dust”.<br />
113
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