GHS Classification Guidance for the Japanese Government

UNRTDG Class 6.1 is not sub-categorized by exposure route.
Category 1 2 3 4
(Oral) GHS 5 50 300 2000
mg/kg EU classification R28 25 R25 200 R22 2000
(Dermal)
GHS 50 200 1000 2000
mg/kg EU classification R27 50 R24 400 R21 2000
(Vepours) GHS 0.5 2 10 20
mg/L EU classification R26 0.5 R23 2 R20 20
(Dust・mist) GHS 0.05 0.5 1 5
mg/L EU classification R26 0.25 R23 1 R20 5
(Note)”Oral” and “Dermal” are LD50 values, and “Vapours” and “Dusts and Mists” are LC50
values. As for “Gases”, the description is omitted because they are not defined in the present EU
classification.
D) Guidance concerning data
Care should be taken since, even when test data within 4 hours are not available, findings of
other test reports suggest that units for halation toxicity vary depending on the shape of the
inhaled substance. Classification should be performed on the basis of the values for gases
(ppmV) if the test atmosphere consists of a gaseous phase including vapour that is substantially
a gaseous phase, values for vapours (mg/L)if the test atmosphere consists of a liquid with a
relatively low boiling point, and values for mists (mg/L)for other cases.
(Reference)Conversion of ppmV and mg/L units(at 25°C and atmospheric pressure)
(ppmV ) = {( mg/L)× 24.45 × 10 3 } / molecular weight
(mg/L) = {( ppmV )× molecular weight × 10 -3 } / 24.45
(4)Guidance for classification and judgment
A) Background of this item and points to be noted
As for background of this item, refer to Part 1, Introduction.
As for substances of which only mixture data are available (only mixed or diluted with
solvents without toxicity), their GHS classification as pure substances are performed by
appropriately estimating corresponding values from concentrations, and the estimation
processes should be described.
B) Decision when there are multiple descriptions related to Acute Toxicity
When multiple descriptions related to Acute Toxicity with highly reliable data are available,
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