E. Coli

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Review of Literature
Dobrgan et al. (2006) reported that Salmonella enterica serovars
typhi, paratyphi A, and sendai are human-adapted pathogens that
cause typhoid (enteric) fever. The acute prevalence in some global
regions and the disease severity of typhoid salmonella have
necessitated the development of rapid and specific detection tests.
Most of methodologies currently used to detect serovar typhi don’t
identify serovars paratyphi A or sendai. To assist in this aim,
comparative sequence analyses were performed at the loci of core
bacterial genetic determinants and salmonella pathogenecity island 2
genes encoded by clinically significant S. enterica serovars. Genetic
polymorphisms specific for serovars typhi (at tarps), as well as
polymorphisms unique to human-adapted typhoidal serovars (at
second step), were observed. Further more, entire coding sequence
unique to human-adapted Typhoidal salmonella strains (i.e. serovar
specific genetic loci rather than polymorphisms) were observed in
publicly available comparative genomic DNA micro array data sets.