Syn-ake-Pentapharm

EFFICACY
SMOOTHING AND ANTI WRINKLE EFFECT OF SYN ® -AKE
The study was performed on 45 volunteers. SYN ® -AKE has been compared against
placebo and against a reference substance. Both products have been used at the
recommended use level. The study lasted 28 days with a twice-daily application.
SIGNIFICANT DECREASE OF EXPRESSION LINES ON THE FOREHEAD
Both products have been used at
the recommended use level.
SYN ® -AKE at 4% and the
reference substance acetyl
hexapeptide-3 at 10 %.
SYN ® -AKE clearly showed a
higher efficacy for all tested
parameters.
Ra: average roughness
Rt: maximum difference between the
highest peak and the deepest furrows
Rz: mean value of these different
maxima
A decrease of the Ra expresses a
smoothed relief.
A decrease of the Rt and Rz expresses
a decrease of the wrinkles’ depth.
Using the PRIMOS ® technique,
parallel stripe patterns are
projected on the sample with
successive phase shift. The
analysis of fringe deformations
provided a qualitative as well as
quantitative evaluation of each
height profile.
The skin relief of Volunteer #9 is
shown on the illustration on the
right. The red profile presents the
relief observed on the print at Day
0 and the green profile the relief
at Day 28.
We can observe a decrease of
depth of the deepest wrinkles.
Ra Rz Rt
105
Smoothing Effect: - 4% (Ra)
100
95
Anti-wrinkle Effect: - 2% (Rz)
90
85
80
75
70
Smoothing Effect: - 21% (Ra)
Anti-wrinkle Effect: - 20% (Rz)
(**)
65
60
Day 0 Placebo Competitive
Product (10%)
SYN-AKE (4%)
(**)
Measurement of decrease
against Day 0 [%]
(*)
(**) p≤0.01
(*) p