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The Contribution of cocoa additive to cigarette smoking addiction

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RIVM report 650270002 Page 92 <strong>of</strong> 207<br />

Tryp<strong>to</strong>phan<br />

3.5 Tryp<strong>to</strong>phan<br />

GENERAL<br />

IUPAC systematic name: L-2-Amino-3-(indol-3-yl)propionic acid (1).<br />

Synonyms: L-Tryp<strong>to</strong>phan; Tryp<strong>to</strong>phanum (1) (S)-alpha-amino-1H-indole-3propanoic<br />

acid; l-alpha-aminoindole-3-propionic acid; l-alpha-amino-3indolepropionic<br />

acid; 2-amino-3-indolylpropanoic acid; l-beta-3-indolylalanine (2).<br />

Molecular formula: C11H12N2O2 (1-4)<br />

N<br />

H<br />

O<br />

NH 2<br />

OH<br />

Molecular weight: 204.2 g/mol (1-4)<br />

Alifatic: propyl-chain (4)<br />

Aromatic: indole ring (4)<br />

N containing: yes (4)<br />

Halogen containing: No (4)<br />

CAS registry no.: 73-22-3 (3).<br />

S<strong>to</strong>rage: Not stable in light (3).<br />

R/S classification: No data available.<br />

dangercode (transport): No data available.<br />

Properties:<br />

melting point: E 280 ºC (3).<br />

boiling point: No data available<br />

density: E 1340 kg/m 3 (3).<br />

refractive index: No data available<br />

solubility: Sparingly soluble in water; slightly soluble in alcohol; practically<br />

insoluble in ether; dissolves in dilute mineral acids and in dilute solutions <strong>of</strong> alkali<br />

hydroxides (1). Moderate soluble in water (E 1.1 g/100 ml) (3).<br />

substance:<br />

color: white/light yellow (3).<br />

liquid/gas/powder: a white or almost white crystalline or amorphous powder<br />

(1).<br />

odor/taste: odourless (3).<br />

volatility: No data available<br />

pKa: pKa = 2.38, pKb = 9.34 and pI = 5.89 (4).<br />

PA: kcal/mol: No data available<br />

flammability: No data available<br />

FP =<br />

FL Limits =<br />

IT =<br />

decomposition temperature: E 280ºC (3), 290 – 295ºC (5).<br />

vapour pressure/ vapour tension (20 °C): No data available<br />

vapour pressure (50 °C): No data available

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