The Contribution of cocoa additive to cigarette smoking addiction

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Theobromine
(22) Wilkinson JM, Pollard I. Accumulation of theophylline, theobromine and
paraxanthine in the fetal rat brain following a single oral dose of caffeine.
Brain research Developmental brain research, 1993; 75(2): 193-199.
(23) Shi D, Daly JW. Chronic effects of xanthines on levels of central receptors in
mice. Cellular and molecular neurobiology, 1999; 19(6): 719-732.
(24) Slattery ML, West DW. Smoking, alcohol, coffee, tea, caffeine, and
theobromine: risk of prostate cancer in Utah (United States). Cancer causes
and control, 1993; 4(6): 559-563.
(25) Wang Y, Waller DP. Theobromine toxicity on Sertoli cells and comparison
with cocoa extract in male rats. Toxicology letters, 1994; 70(2): 155-164.
(26) Wang Y, Waller DP, Hikim AP, Russell LD. Reproductive toxicity of
theobromine and cocoa extract in male rats. Reproductive toxicology, 1992;
6(4): 347-353.
(27) Martinez L, Gutierrez P, Hernandez A, Martinez PJ, Thomas J. Interactions
between lignocaine and caffeine, theophylline and theobromine. An. R. Acad.
Farm., 1986; 52(3): 505 - 515.
(28) Miners Jo, Attwood J, Wing L-MH, Birkett DJ. Influence of cimetidine,
sulfinpyrazone, and cigarette smoking on theobromine metabolism in man.
Drug Metabolism And Disposition, 1985; 13(5): 598 - 601.
(29) Gale GR, Smith AB. Interaction of caffeine with acetaminophen in mice:
schedule dependency of the antagonism by caffeine of acetaminophen
hepatotoxicity and the effects of caffeine metabolites, allopurinol, and diethyl
ether. Res Commun Chem Pathol Pharmacol, 1988; 59(3): 305-320.
(30) Vallerand AL, Wang LC, Jacobs I. Influence of Theobromine on Heat
Production and Body Temperatures in Cold-Exposed Humans: A Preliminary
Report. Govt Reports Announcements & Index (GRA &I ), 1990; Issue 10:
NTIS/AD-A217 203/9.
(31) Schiffman SS, Gill JM, Diaz C. Methyl xanthines enhance taste: evidence for
modulation of taste by adenosine receptor. Pharmacol Biochem Behav, 1985;
22 (2): 195-203.
(32) Liu DK, Owens GF. Methylxanthine treatment of rats reduces 2,5oligoadenylate
synthesis in liver nuclei. J Toxicol Environ Health, 1987;
20(4): 379-386.
(33) Coulson R, Scheinman SJ. Xanthine effects on renal proximal tubular
function and cyclic AMP metabolism. J Pharmacol. Exp. Ther., 1989; 248 (2):
589-595.
(34) McPhee MD, Whiting SJ. The effect of adenosine and adenosine analogs on
methylxanthine-induced hypercalciuria in the rat. Canadian Journal of
Physiology and Pharmacology, 1989; 67 (10): 1278-1282.