Occupational Intakes of Radionuclides Part 1 - ICRP

2093
2094
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2100
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2110
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DRAFT REPORT FOR CONSULTATION
Table 4 Sources of data on thoracic retention used in Figure 7
COBALT URANIUM PLUTONIUM
Co1 Newton and Rundo
(1971)
U1 Ronen (1969) Pu1 Newton et al (1983)
Co2 Gupton and Brown
(1972)
U2 Saxby et al (1964) Pu2 Ramsden (1976)
Co3 Raghavendran et al U3 Rundo (1965) Pu3 Ramsden et al (1978);
(1978)
Ramsden (1984)
Co4 Ramsden (1984) U4 Schultz (1966) Pu4 Bihl et al (1988a,b,c)
Co5 Davis et al (2007) U5 Scott and West (1967) Pu5 Foster (1991)
U6 West and Scott (1966) Pu6 ORAUT (2007)
CERIUM U7 West and Scott (1969) Pu7 Carbaugh and La Bone
(2003)
Ce1 Tyler and Lister
(1973)
U8 West et al (1979)
U9 Crawford-Brown and
Wilson (1984)
AMERICIUM
TANTALUM U10 Kvasnicka (1987) Am1 Fry (1976)
Ta1 Newton (1977) U11 Price (1989) Am2 Toohey and Essling
(1980)
Am3 Newton et al (1983)
195
Au-LABELLED
Am4 Wernli and Eikenberg
TEFLON
T1 Philipson et al (1996)
(2007)
(123) A review of long-term lung retention data has therefore been conducted
(Gregoratto et al, 2010). Three other major relevant studies were identified that were
published since the HRTM was finalised. Their results, together with those on which
the HRTM was based, were used to develop a new compartment model of particle
transport from the AI region.
(124) Philipson et al (1996) followed lung retention in 10 volunteers for about 3
years after inhalation of 195 Au-labelled Teflon particles. The duration of this study
was about three times longer than for the experiments available when the HRTM was
developed, and it seems likely that there was less leakage of the radioactive label from
the test particles. Lung retention has been followed for over thirty years in workers
who inhaled plutonium oxide during a fire at the Rocky Flats Plant (RFP) in October
1965 (Mann and Kirchner, 1967; ORAUT 2007): another group who should be
representative of nuclear industry workers (Gregoratto et al, 2010). Kuempel et al
(2001) developed a model of particle retention in the AI region that is both
physiologically more realistic and simpler than that in the original HRTM. Instead of
the three AI compartments in the HRTM, it has an alveolar compartment which clears
both to the bronchial tree and to an interstitial compartment which clears to lymph
nodes. This model was applied to a group of U.S. coal miners with exposure histories
from which particle mass deposition rates could be assessed, and autopsy
measurements of dust concentration in lung (and also for lymph nodes in about 50%
of cases). The model was considered to be the simplest consistent with the data and
no evidence was found for impaired clearance at high lung loadings over the range
60