Occupational Intakes of Radionuclides Part 1 - ICRP
Occupational Intakes of Radionuclides Part 1 - ICRP
Occupational Intakes of Radionuclides Part 1 - ICRP
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DRAFT REPORT FOR CONSULTATION<br />
Biokinetic model<br />
A mathematical model adopted in this report for the Reference Worker.<br />
Reference biokinetic model describes the intake, uptake and retention <strong>of</strong> a<br />
radionuclide in various organs or tissues <strong>of</strong> the body and the subsequent<br />
excretion from the body by various pathways.<br />
Bronchial Region (BB)<br />
<strong>Part</strong> <strong>of</strong> the respiratory tract, consisting <strong>of</strong> the trachea (generation 0) and<br />
bronchi, airway generations 1 through 8.<br />
Bronchiolar Region (bb)<br />
<strong>Part</strong> <strong>of</strong> the respiratory tract, consisting <strong>of</strong> the bronchioles and terminal<br />
bronchioles; airway generations 9 through 15.<br />
Bone surfaces<br />
See ‘Endosteum’.<br />
Class SR-0<br />
Insoluble and nonreactive. Negligible deposition in the respiratory tract.<br />
Class SR-1<br />
Soluble or reactive. Deposition throughout the respiratory tract, which may be<br />
complete or incomplete.<br />
Class SR-2<br />
Highly soluble or reactive. Complete deposition in the respiratory tract with<br />
instantaneous uptake to body fluids.<br />
Clearance<br />
The removal <strong>of</strong> material from the respiratory tract by particle transport and by<br />
absorption into body fluids.<br />
Compartment<br />
In this report series: Mathematical pool <strong>of</strong> radioactive materials in the body<br />
which can be characterised by first order kinetics; a compartment can be<br />
associated with an organ (as for example the liver), a part <strong>of</strong> an organ (as for<br />
example the bronchial region <strong>of</strong> the lungs), a tissue (as for example the bone),<br />
a part <strong>of</strong> a tissue (as for example the bone surface) or another substance <strong>of</strong> the<br />
body (as for example the body fluids). Activity is considered to be uniformly<br />
distributed in a compartment.<br />
Compartments in the particle transport model representing retention <strong>of</strong> material in<br />
each region defined in the Human Respiratory Tract Model:<br />
Original HRTM<br />
AI1 relatively short-term retention (half-time, t½ about 35 d) <strong>of</strong> a fraction,<br />
taken to be 0.3, <strong>of</strong> the deposit in the alveolar-interstitial region.<br />
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