Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

24 AMINOLEVULINIC ACID
AMINOLEVULINIC ACID
Trade name: Levulan Kerastick (Dusa)
Indications: Non-hyperkeratotic actinic keratoses of face & scalp
Category: Photosensitizer; Protoporphyrin IX (PpIX)
Half-life: 30 ± 10 hours
Reactions
Skin
Burning (>50%)
(2006): Schleyer V+, J Eur Acad Dermatol Venereol 20(7), 823
(1997): Jeffes EW+, Arch Dermatol 133, 727
(1996): Stender IM+, Br J Dermatol 135, 454
Crusting (64–71%)
(2000): Hongcharu W+, J Invest Dermatol 115, 183
(1995): Lang S+, Laryngorhinootologie (German) 74, 85
Dermatitis
(2004): Wulf HC+, Br J Dermatol 150(1), 143
(1998): Gnaizdowska B+, Contact Dermatitis 38, 348
Edema (35%)
(2004): Dragieva G+, Transplantation 77(1), 115
(2004): Piacquadio DJ+, Arch Dermatol 140(1), 41
(2003): Alster TS+, J Drugs Dermatol 2(5), 501
(1997): Jeffes EW+, Arch Dermatol 133, 727
(1995): Lang S+, Laryngorhinootologie (German) 74, 85
Erosions (14%)
Erythema (99%)
(2006): Misra A+, Plast Reconstr Surg 117(7), 2522
(2006): Wiegell SR+, Br J Dermatol 154(5), 969
(2004): Dragieva G+, Transplantation 77(1), 115
(2004): Piacquadio DJ+, Arch Dermatol 140(1), 41
(2003): Alster TS+, J Drugs Dermatol 2(5), 501
(2003): Wiegell SR+, Arch Dermatol 139(9), 1173
(1997): Jeffes EW+, Arch Dermatol 133, 727
(1995): Lang S+, Laryngorhinootologie 74, 85
Exfoliative dermatitis (when treated for acne)
(2006): Wiegell SR+, Br J Dermatol 154(5), 969
(2000): Hongcharu W+, J Invest Dermatol 115, 183
(1996): Stender IM+, Br J Dermatol 135(3), 454
Hypomelanosis (22%)
Keratoacanthoma
(2006): Maydan E+, J Drugs Dermatol 5(8), 804
Koebner phenomenon (psoriasis)
(1996): Stender IM+, Acta Derm Venereol 76, 392
Melanoma
(1997): Wolf P+, Dermatology 194, 53 (on scalp)
Photosensitivity
(2002): Hinnen P+, J Photochem Photobiol B 68(1), 8
(1999): Ackroyd R+, Photochem Photobiol 70(4), 656
Phototoxicity
(2007): Angell-Petersen E+, Br J Dermatol 156(2), 301
Pigmentation (when treated for acne) (22%)
(2003): Clark C+, Photodermatol Photoimmunol Photomed
19(3), 134 (2%)
(2002): Monfrecola G+, J Photochem Photobiol B 68(2-3), 147
(2000): Hongcharu W+, J Invest Dermatol 115, 183
Pruritus (25%)
Pustules (50%)
(1997): Jeffes EW+, Arch Dermatol 133, 727
Ulcerations (4%)
Urticaria
(2005): Yokoyama S+, JDermatol32(10), 843 (photocontact)
Vesiculation (4%)
Hair
Hair – alopecia
(1999): Ackroyd R+, Photochem Photobiol 70(4), 656
Other
Pain
(2006): Schleyer V+, J Eur Acad Dermatol Venereol 20(7), 823
(2006): Wiegell SR+, Br J Dermatol 154(5), 969
(2003): Clark C+, Photodermatol Photoimmunol Photomed
19(3), 134 (2%)
(2003): Wiegell SR+, Arch Dermatol 139(9), 1173
*Note: To be used in conjunction with the Blue Light Photodynamic
Therapy Illuminator
AMINOPHYLLINE
Synonym: theophylline ethylenediamine
Trade names: Aerolate; Aminophyllin; Bronkodyl; Choledyl;
Corophyllin; Elixophyllin (Forest); Euphyllin; Norphyl; Palaron;
Phyllocontin (Napp); Phyllotemp; Planphylline; Quibron
(Monarch); Slo-Bid; Somophyllin; Tefamin; Theo-Dur; Truphylline
Indications: Prevention or treatment of reversible
bronchospasm
Category: Xanthine alkaloid
Half-life: 3–15 hours (in adult nonsmokers)
Clinically important, potentially hazardous interactions
with: cimetidine, erythromycin, halothane, nilutamide,
prednisone
Reactions
Skin
Adverse effects (sic)
(1995): Simon PA+, JAMA 273(22), 1737
Allergic reactions (sic) (