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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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22 AMIFOSTINE<br />

AMIFOSTINE<br />

Synonyms: ethiofos; gammaphos<br />

Trade names: Ethyol (Medimmune); Ethyol 500<br />

Indications: Nephrotoxicity prophylaxis<br />

Category: Thiophosphate cytoprotective<br />

Half-life: 9 minutes<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

(2007): Anne PR+, Int J Radiat Oncol Biol Phys 67(2), 445 (4%)<br />

Bullous dermatitis<br />

(2004): Boccia R+, Int J Radiat Oncol Biol Phys 60(1), 302 (3<br />

cases)<br />

Erythema multiforme<br />

(2004): Boccia R+, Int J Radiat Oncol Biol Phys 60(1), 302 (8<br />

cases)<br />

Rash (sic) (10%)<br />

(2000): Sriswasdi C+, J Med Assoc Thai 83, 374<br />

Fever<br />

(2006): Koukourakis MI+, Anticancer Res 26(3B), 2437 (7%)<br />

(2002): Koukourakis MI+, Int J Radiat Oncol Biol Phys 52(1), 144<br />

(7%)<br />

AMIKACIN<br />

Trade names: Amicacina; Amicasil; Amikacin Sulfate (Bedford);<br />

Amikan; Biclin; Biklin; Gamikal; Kanbine; Lukadin; Miacin;<br />

Yectamid<br />

Indications: Short-term treatment of serious infections due to<br />

gram-negative bacteria<br />

Category: Antibiotic, aminoglycoside<br />

Half-life: 1.5–2.5 hours (adults)<br />

Clinically important, potentially hazardous interactions<br />

with: adefovir, aldesleukin, aminoglycosides, atracurium,<br />

bumetanide, cephalexin, doxacurium, ethacrynic acid,<br />

furosemide, succinylcholine, torsemide<br />

Reactions<br />

Skin<br />

Dermatitis<br />

(1989): Rudzki E+, Contact Dermatitis 20, 391<br />

(1985): Holdiness MR, Int J Dermatol 24, 280<br />

Exanthems<br />

Pruritus<br />

(1985): Holdiness MR, Int J Dermatol 24, 280<br />

Rash (sic) (

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