Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Other
Abdominal pain
(2005): Turgeon DK+, J Clin Gastroenterol 39(7), 641
Death
(2004): Andresen V+, Drug Saf 27(5), 283
ALPHA-LIPOIC ACID
Synonyms: Lipoid acid; Thioctic acid; Dihydrothioctic acid
Indications: Diabetic neuropathy, vasodilation, photoaging
Half-life: N/A
Clinically important, potentially hazardous interactions
with: N/A
Reactions
Skin
Dermatitis
(2006): Bergqvist-Karlsson A+, Contact Dermatitis 55(1), 56
Pruritus
(2005): Yadav V+, Mult Scler 11(2), 159
Rash (sic)
(2005): Yadav V+, Mult Scler 11(2), 159
Urticaria
(2005): Yadav V+, Mult Scler 11(2), 159
Other
Abdominal pain
(2005): Yadav V+, Mult Scler 11(2), 159
Anaphylactoid reactions/Anaphylaxis
(2004): Ziegler D, Treat Endocrinol 3(3), 173 (3 cases)
ALPRAZOLAM
Trade names: Alprox; APO-Alpraz; Cassadan; Kalma; Nu-
Alprax; Ralozam; Tafil; Xanax (Pfizer)
Indications: Anxiety, depression, panic attacks
Category: Benzodiazepine
Half-life: 11–16 hours
Clinically important, potentially hazardous interactions
with: alcohol, aprepitant, clarithromycin, CNS depressants,
delavirdine, digoxin, efavirenz, fluconazole, fluoxetine,
fluvoxamine, grapefruit juice, indinavir, itraconazole,
ivermectin, kava, ketoconazole, propoxyphene, ritonavir,
saquinavir, St John’s wort
Reactions
Skin
Acne
(1985): Levy MH+, Semin Oncol 12, 411
Allergic reactions (sic)
(1996): Bhatia MS, Indian J Med Sci 50, 285 (to tartrazine)
Angioedema (tongue)
(2006): Sellas-Dupre G+, Med Clin (Barc) 127(10), 399
Dermatitis (3.8%)
(1984): Elie R+, J Clin Psychopharmacol 4, 125
(1982): Fawcett JA+, Pharmacotherapy 2, 243
(1981): Evans RL, Drug Intell Clin Pharm 15, 633
(1981): Kolin IS+, J Clin Psychiatry 42, 169
Diaphoresis (15.8%)
Edema (4.9%)
Exanthems
(1988): Warnock JK+, Am J Psychiatry 145, 425
Photosensitivity
(1999): Watanabe Y+, JAmAcadDermatol40, 832
(1998): Pazzagli L+, Pharm World Sci 20, 136 (with fluoxetine)
(1994): Shelley WB+, Cutis 54, 70 (observation)
(1990): Kanwar AJ+, Dermatologica 181, 75
Phototoxicity
(1993): Litt JZ, Beachwood, OH (personal case) (observation)
(1991): Shelley WB+, Cutis 48, 187 (observation)
Pruritus
(1988): Islas JA+, Curr Ther Res 43, 384
(1982): Chouinard G+, Psychopharmacol 77, 229
Purpura
Rash (sic) (10.8%)
(1987): Fyer AJ+, Am J Psychiatry 144, 303
(1985): Jerram TC, Side Eff Drugs Annu 9, 39
(1985): Rush AJ+, Arch Gen Psychiatry 42, 1154
(1983): Davison K+, Psychopharmacol 80, 308
Urticaria
Xerosis
(1982): Chouinard G+, Psychopharmacol 77, 229
Mucosal
Oral ulceration
Sialopenia (32.8%)
Sialorrhea (4.2%)
Xerostomia (14.7%)
(1988): Islas JA+, Curr Ther Res 43, 384
(1984): Elie R+, J Clin Psychopharmacol 4, 125
(1982): Chouinard G+, Psychopharmacol 77, 229
(1982): Fawcett JA+, Pharmacotherapy 2, 243
(1981): Evans RL, Drug Intell Clin Pharm 15, 633
Other
Death
(2005): Wolf BC+, JForensicSci50(1), 192 (with oxycodone)
Gynecomastia
Pseudolymphoma
(1995): Magro CM+, JAmAcadDermatol32, 419
ALPROSTADIL
Synonyms: PGE; prostaglandin E 1
Trade names: Caverject (Pfizer); Edex (Schwarz); Lyple;
Minprog; Muse (Vivus); Palux; Prostin VR (Pfizer); Prostine VR;
Prostivas
Indications: Impotence, to maintain patent ductus arteriosus
Category: Prostaglandin
Half-life: 5–10 minutes
Reactions
ALPROSTADIL 19
Skin
Diaphoresis (