Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

INTRODUCTION
side effect, I have employed the most illustrative and most
recent citation(s) in the literature.
In this new, 2008 state-of-the-art fourteenth edition, I
have cited more than 30,000 references and sources from
journals articles, books and observations as well as from dermatologists
from all over the world via the Internet and from
personal communications. This Manual includes all references,
28,367, from 1980 until October, 2007. The complete
number, 39,599, of references, as far back as 1922, can
be found on the website, (www.drugeruptiondata.com)
The first part of the Manual lists, in alphabetical order, all
the listed 1,195 Generic drugs and over 6,000 Trade
name drugs with their corresponding names for easy access
to the A-Z section – the main body of the Manual.
Next comes a listing of the various Classes of drugs, and
those Generic drugs that belong to each class.
The major portion of the Manual – the body of the work –
lists the 1,195 Generic drugs, herbals and supplements in
alphabetical order and the adverse reactions that can arise
from their use along with the appropriate references.
The last parts of the Manual include a description of the 34
most common Reaction Patterns; a listing of those drugs
that can occasion more than 100 different reaction patterns,
including, among others, Acne, Acute generalized
exanthematous pustulosis, Alopecia, Aphthous
stomatitis, Bullous eruptions, Bullous pemphigoid,
Erythema multiforme, Erythema nodosum,
Exanthems, Exfoliative dermatitis, Fixed eruptions,
Lichenoid eruptions, Lupus erythematosus,
Onycholysis, Pemphigus, Photosensitivity, Pityriasis
rosea, Pruritus, Psoriasis, Purpura, Pustular eruptions,
Stevens-Johnson syndrome, Toxic epidermal
necrolysis, Urticaria, and Vasculitis.
USAGE, STYLE & CONVENTIONS EMPLOYED IN
THIS MANUAL
The Generic Drug name is at the top of each page.
A category for Synonyms (where applicable) follows.
The Trade (Brand) Name(s) are then listed alphabetically.
When there are many Trade Names, the ten (or so)
most commonly recognized ones are listed. This compilation
lists and cross-references both the Trade and Generic
names of all the cataloged drugs. Following the more common
Trade Name drugs are recorded – in parentheses –
the latest name of the pharmaceutical company that is marketing
the drug. As a result of acquisitions, mergers, and
other factors in the pharmaceutical industry, many of the
names of the companies have changed from earlier editions
of this Manual.
Beneath the Trade Name listing is a list of Other Common
Trade Names, those drugs from other countries.
Then appears the Indication(s), the Class in which the drug
belongs and the Half-Life of each drug, when known. On
occasion, an important or pertinent Note will follow.
viii
Reactions: These are the Adverse Reactions to the
particular Generic drug. They are classified in six Categories:
Skin, Musocal, Hair, Nails, Eyes, and Other.
(Other refers to Mucous Membrane, Teeth, Muscle and
various other forms of Reactions.) Reactions are listed
alphabetically in each Category.
Under each Reaction Pattern are listed the References
(the sources of the information). These are arranged in
reverse chronological order – the most recent reference
appearing first on the list.
References in the English language predominate. For the
few foreign references, we have resorted to the summary or
abstract. The majority of the citations come from the JAm
Acad Dermatol, Arch Dermatol, Cutis, Int J Dermatol, Contact
Dermatitis, Br J Dermatol, JAMA, Lancet, BMJ, Aust J Dermatol,
N Engl J Med, Ann Intern Med, and other prominent and easily
accessible journals.
As a function of space limitations, the list of References
has been restricted mainly to those after 1980. Please
note, however, that all References going as far back as
1922 can still be accessed on our website – www.
drugeruptiondata.com.
Many reference works have been consulted in the course
of compiling this Manual. These include:
(2002): Stockley IH, STOCKLEYS DRUG
INTERACTIONS, Pharmaceutical Press, London and
Chicago
(1998): Kauppinen K et al, SKIN REACTIONS TO
DRUGS, CRC Press, Boca Raton
(1996): Bruinsma W, A GUIDE TO DRUG
ERUPTIONS, The File of Medicines, PO Box 21, 1474
HJ Oosthuizen, Netherlands.
(1994): Goldstein S & Wintroub BU, ADVERSE
CUTANEOUS REACTIONS TO MEDICATION,
CoMedica, New York.
(1992): Zürcher K & Krebs A, CUTANEOUS DRUG
REACTIONS, Karger, Basel.
(1992): Breathnach SM & Hintner H, ADVERSE DRUG
REACTIONS and the SKIN, Blackwell, Oxford.
(1988): Bork K, CUTANEOUS SIDE EFFECTS OF
DRUGS, WB Saunders, Philadelphia.
There are occasions when there are very few or no
adverse reactions to a specific drug. These drugs are still
included in the Manual since there is often a positive significance
in negative findings.
As a departure from the official, conventional and established
style guide, the order of each Reference will appear
as follows:
The year in parentheses. The most recent citation appears
first. This approach seems to be much more logical.
Last name and initial(s) of the principal author.