Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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ADALIMUMAB Synonym: D2E7 Trade name: Humira (Abbott) Indications: Rheumatoid arthritis Category: Cytokine inhibitor; TNF inhibitor Half-life: 10–20 days Clinically important, potentially hazardous interactions with: None Reactions Skin Allergic reactions (sic) (1%) Angioedema (2006): Sanchez-Cano D+, Clin Exp Rheumatol 24(5 Suppl 42), S128 Bacterial infections (2005): Botsios C, Autoimmun Rev 4(3), 162 Carcinoma Cellulitis Eosinophilic cellulitis (2006): Boura P+, Ann Rheum Dis 65(6), 839 Erysipelas Erythema (2005): Sfikakis PP+, Arthritis Rheum 52(8), 2513 (1 case) Erythema multiforme (2004): Beuthien W+, Arthritis Rheum 50(5), 1690 Fungal dermatitis Herpes zoster Lupus erythematosus (

10 ADAPALENE (2003): Brand B+, JAmAcadDermatol49(3 Suppl), S227 (2001): Queille-Roussel C+, Clin Ther 23(2), 205 (1998): Bonardeaux C+, Rev Med Liege 53(2), 109 (mild) Pruritus (

ADALIMUMAB<br />

Synonym: D2E7<br />

Trade name: Humira (Abbott)<br />

Indications: Rheumatoid arthritis<br />

Category: Cytokine inhibitor; TNF inhibitor<br />

Half-life: 10–20 days<br />

Clinically important, potentially hazardous interactions<br />

with: None<br />

Reactions<br />

Skin<br />

Allergic reactions (sic) (1%)<br />

Angioedema<br />

(2006): Sanchez-Cano D+, Clin Exp Rheumatol 24(5 Suppl<br />

42), S128<br />

Bacterial infections<br />

(2005): Botsios C, Autoimmun Rev 4(3), 162<br />

Carcinoma<br />

Cellulitis<br />

Eosinophilic cellulitis<br />

(2006): Boura P+, Ann Rheum Dis 65(6), 839<br />

Erysipelas<br />

Erythema<br />

(2005): Sfikakis PP+, Arthritis Rheum 52(8), 2513 (1 case)<br />

Erythema multiforme<br />

(2004): Beuthien W+, Arthritis Rheum 50(5), 1690<br />

Fungal dermatitis<br />

Herpes zoster<br />

Lupus erythematosus (

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