Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

4 ACETAMINOPHEN
ACETAMINOPHEN
Synonyms: APAP; paracetamol
Trade names: Abenol; Anacin-3 (Wyeth); Anaflon; Ben-U-Ron;
Bromo-Seltzer; Darvocet-N (aaiPharma); Datril; Doliprane;
Excedrin (Bristol-Myers Squibb); Geluprane; Liquiprin; Lorcet
(Forest); Mapap; Neopap; Panadol (GSK); Percocet (Endo);
Percogesic; Phenaphen; Sinutab; Tylenol (Ortho-McNeil);
Valadol; Vicodin (Abbott)
Indications: Pain, fever
Category: Analgesic, non-narcotic
Half-life: 1–3 hours
Clinically important, potentially hazardous interactions
with: alcohol, cholestyramine, didanosine, dong quai,
melatonin
Note: Acetaminophen is the active metabolite of phenacetin
Reactions
Skin
Acute generalized exanthematous pustulosis (AGEP)
(2004): Wohl Y+, Skinmed 3(1), 47
(2003): Mashiah J+, Arch Dermatol 139(9), 1181
(2001): Cohen AD+, Int J Dermatol 40(7), 458
(2000): Halevy S+, Clin Exp Dermatol 25(8), 652
(1998): Leger F+, Acta Derm Venereol 78, 222
(1996): DeConinck AL+, Dermatology 193, 338
(1995): Moreau A+, Int J Dermatol 34, 263 (passim)
(1991): Roujeau J-C+, Arch Dermatol 127, 1333
Allergic granulomatous angiitis (Churg–Strauss syndrome)
(2005): Masuzawa A+, Intern Med 44(5), 496
Angioedema (