Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

(1989): Valencia ME+, Rev Clin Esp (Spanish) 185, 167 (blue
striae)
(1989): Yarchoan R+, NEnglJMed321, 726
(1988): Azon-Masoliver A+, Arch Dermatol 124, 1570
(1988): Gonzalez-Lahoz JM+, Rev Clin Esp (Spanish) 183, 278
(bluish)
(1988): Vaiopoulos G+, AnnInternMed108, 777
(1987): Furth PA+, AnnInternMed107, 350
Other
Death
Hypersensitivity
Lipoatrophy
(2004): McComsey GA+, Clin Infect Dis 38(2), 263
Lipodystrophy
(2001): Bogner JR+, J Acquir Immune Defic Syndr 27(3), 237
Myalgia/Myositis/Myopathy/Myotoxicity (1%)
Scleroderma
(2000): Dellaripa PF+, Mayo Clin Proc 75(6), 643
Mucosal
Vaginitis (>1%)
Other
Cough
(2001): Spector SL, Ann Allergy Asthma Immunol 86(6 Suppl 1), 18
Myalgia/Myositis/Myopathy/Myotoxicity (3.2%)
ZINC
Trade names: Calamine; Cold-Eeze (The Quigley Corp); Galzin;
Zicam
Category: Food supplement; Trace element
Half-life: N/A
Clinically important, potentially hazardous interactions
with: chlorothiazide, chlorthalidone, ciprofloxacin, cisplatin,
deferoxamine, demeclocycline, ethambutol, gatifloxacin,
hydrochlorothiazide, indapamide, levofloxacin, metolozone,
minocycline, moxifloxacin, ofloxacin, propofol, valproic acid
Note: Zinc is found in meats, seafood, dairy products, legumes, nuts,
whole grains. Zinc oxide and zinc sulfate are used to fortify wheat
products
Reactions
ZINC 585
Skin
Allergic granulomatous angiitis (Churg–Strauss syndrome)
(1989): Jordaan HF+, Clin Exp Dermatol 14(3), 227
(1989): Sandler M+, SAfrMedJ75(7), 342
Burning
Dermatitis
(2003): Shimizu T+, Clin Exp Dermatol 28(6), 675 (dental fillings)
(1997): Nielsen NH+, Am J Contact Dermat 8(3), 170 (zinc
pyrithione shampoo)
(1988): Nigam PK+, Contact Dermatitis 19(3), 219 (zinc
pyrithione)
Erythroderma
Itching
Lupus erythematosus
Palmoplantar pustulosis
(2005): Yanagi T+, Lancet 366(9490), 1050 (dental fillings)
Pigmentation
(2002): Greenberg JE+, JCutanPathol29(10), 613
Mucosal
Oral lichen planus
(2002): Ido T+, Contact Dermatitis 47(1), 51
Oral mucosal irritation
(1998): Garland ML+, Ann Pharmacother 32(1), 63 (zinc
gluconate)
(1984): Eby GA+, Antimicrob Agents Chemother 25(1), 20 (zinc
gluconate)
Xerostomia
Other
Abdominal pain
(1987): Samman S+, Med J Aust 146(5), 246
Candidiasis
(1993): Schlesinger L+, Acta Paediatr 82(9), 734
Nephrotoxicity
(1999): Barceloux DG, J Toxicol Clin Toxicol 37(2), 279
Toxicity (sic)
(2002): Igic PG+, Mayo Clin Proc 77(7), 713