Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Bullous dermatitis (2001): Christ EA+ (poster at meeting of the American Federation for Medical Research) Dermatitis Diaphoresis (2001): Hebert AA+, J Clin Psychiatry 62(suppl 14), 22 Edema (2002): Witters I+, Prenat Diagn 22(9), 834 Erythema multiforme (5%) Fixed eruption (1997): Chan HL+, JAmAcadDermatol36, 259 Furunculosis (

568 VALRUBICIN VALRUBICIN Trade name: Valstar (Celltech) Indications: Bladder carcinoma Category: Antibiotic, anthracycline Half-life: N/A Clinically important, potentially hazardous interactions with: None Reactions Skin Irritation (sic) (2%) (2003): Irons BK+, Ann Pharmacother 37(7–8), 1024 (2002): Biswas PN+, JHumHypertens16(11), 795 (2000): de la Serna Higuera C, Med Clin (Barc) (Spanish) 114, 599 (1998): Frye Cb+, Pharmacotherapy 18, 866 Bullous pemphigoid (2003): Femiano F, Minerva Stomatol 52(4), 187 Eczema (2006): Selden ST, Chesapeake VA (from Internet) (observation) Edema (>1%) (2000): Prat H, Rev Med Chil (Spanish) 128, 475 (1996): Corea L+, Clin Pharmacol Ther 60, 341 Facial edema (2002): Biswas PN+, JHumHypertens16(11), 795 Lupus erythematosus (2006): Sontheimer RD, Oklahoma City, OK (from Internet) (observation) Photosensitivity (1998): Frye Cb+, Pharmacotherapy (18) 866 Pruritus (>2%) Psoriasis (2005): Litt JZ, Beachwood, OH (personal case) (observation) Rash (sic) (>2%) Urticaria (2000): de la Serna Higuera C, Med Clin (Barc) (Spanish) 114, 599 Mucosal Aphthous stomatitis (1–10%) Xerostomia (>10%) Nails Nails – onychocryptosis Nails – pigmentation Other Cough (2002): Biswas PN+, JHumHypertens16(11), 795 (2000): Prat H, Rev Med Chil 128, 475 Death (2001): Briggs GG+, Ann Pharmacother 35(7), 859 Injection-site extravasation (

568 VALRUBICIN<br />

VALRUBICIN<br />

Trade name: Valstar (Celltech)<br />

Indications: Bladder carcinoma<br />

Category: Antibiotic, anthracycline<br />

Half-life: N/A<br />

Clinically important, potentially hazardous interactions<br />

with: None<br />

Reactions<br />

Skin<br />

Irritation (sic) (2%)<br />

(2003): Irons BK+, Ann Pharmacother 37(7–8), 1024<br />

(2002): Biswas PN+, JHumHypertens16(11), 795<br />

(2000): de la Serna Higuera C, Med Clin (Barc) (Spanish)<br />

114, 599<br />

(1998): Frye Cb+, Pharmacotherapy 18, 866<br />

Bullous pemphigoid<br />

(2003): Femiano F, Minerva Stomatol 52(4), 187<br />

Eczema<br />

(2006): Selden ST, Chesapeake VA (from Internet) (observation)<br />

Edema (>1%)<br />

(2000): Prat H, Rev Med Chil (Spanish) 128, 475<br />

(1996): Corea L+, Clin Pharmacol Ther 60, 341<br />

Facial edema<br />

(2002): Biswas PN+, JHumHypertens16(11), 795<br />

Lupus erythematosus<br />

(2006): Sontheimer RD, Oklahoma City, OK (from Internet)<br />

(observation)<br />

Photosensitivity<br />

(1998): Frye Cb+, Pharmacotherapy (18) 866<br />

Pruritus (>2%)<br />

Psoriasis<br />

(2005): Litt JZ, Beachwood, OH (personal case) (observation)<br />

Rash (sic) (>2%)<br />

Urticaria<br />

(2000): de la Serna Higuera C, Med Clin (Barc) (Spanish)<br />

114, 599<br />

Mucosal<br />

Aphthous stomatitis (1–10%)<br />

Xerostomia (>10%)<br />

Nails<br />

Nails – onychocryptosis<br />

Nails – pigmentation<br />

Other<br />

Cough<br />

(2002): Biswas PN+, JHumHypertens16(11), 795<br />

(2000): Prat H, Rev Med Chil 128, 475<br />

Death<br />

(2001): Briggs GG+, Ann Pharmacother 35(7), 859<br />

Injection-site extravasation (

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