Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

564 URACIL/TEGAFUR
(1984): Sun CC+, Photodermatol 1(2), 94
Pigmentation
(1990): Del Pozo LJ+, Med Cutan Ibero Lat Am 18(1), 78
Rash (sic)
(1997): Pazdur R+, Invest New Drugs 15(2), 123 (with
leucovorin)
Raynaud’s phenomenon
(2000): Seishima M+, Eur J Dermatol 10(1), 55
Scleroderma
(2000): Kono T+, JAmAcadDermatol42(3), 519
Side effects
(1999): Revenga F, Int J Dermatol 38(12), 955
(1997): Rios-Buceta L+, Acta Derm Venereol 77(1), 80
Toxicity (sic)
(1997): Ribas A+, ClinOncol(RCollRadiol)9(4), 269 (with
leucovorin)
Mucosal
Mucositis
(2004): Nagy B+, Magy Onkol 48(2), 145 (56%)
(2004): Okita J+, Auris Nasus Larynx 31(1), 43 (with carboplatin)
(2001): Wellington K+, Drugs Aging 18(12), 935
(1995): Gonzalez-Baron M+, Eur J Cancer 31A(13–14), 2215
(with leucovorin)
Oral mucositis
(2003): Iwase H+, Int J Clin Oncol 8(5), 305 (with cisplatin) (4%)
(1998): Nogue M+, Cancer 83(2), 254 (with leucovorin) (18%)
(1997): Kim YH+, Oncology (Williston Park) 11(9 Suppl 10), 119
(with leucovorin)
Stomatitis
(2004): Feliu J+, Br J Cancer 91(10), 1758 (with oxaliplatin) (1%)
(1997): Pazdur R+, Invest New Drugs 15(2), 123 (with
leucovorin)
(1994): Tanaka K+, Gan To Kagaku Ryoho 21(8), 1229 (18%)
Nails
Nails – brittle
Nails – changes
(1990): Unda Urzaiz M+, Arch Esp Urol 43(2), 143
Nails – pigmentation
(2004): Chen GY+, Acta Derm Venereol 84(3), 238
(1991): Llistosella E+, Cutis 1991 Sep 48(3), 205
Nails – ridging
Eyes
Blepharospasm
(1984): Salminen L+, Am J Ophthalmol 97(5), 649
Conjunctivitis
Other
Abdominal pain
(2001): Wellington K+, Drugs Aging 18(12), 935
(1997): Pazdur R+, Invest New Drugs 15(2), 123 (with
leucovorin)
Infections
(1997): Ribas A+, ClinOncol(RCollRadiol)9(4), 269 (with
leucovorin)
Neurotoxicity
(2004): Feliu J+, Br J Cancer 91(10), 1758 (with oxaliplatin)
(14%)
Pain
(2003): Iwase H+, Int J Clin Oncol 8(5), 305 (with cisplatin) (7%)
(1998): Mani S+, Ann Oncol 9(9), 1035
UROFOLLITROPIN
Trade names: Bravelle; Fertinex; Fertinorm; Follegon; Follimon;
Gonotrop F; Medtrodine HP; Metrodin; Metrodin HP
Indications: Infertility, Polycystic ovary syndrome, Follicle
stimulation
Category: Follicle-stimulating hormone
Half-life: N/A
Clinically important, potentially hazardous interactions
with: None
Reactions
Skin
Exanthems
Urticaria
Xerosis
Hair
Hair – alopecia
Other
Abdominal pain
Chills
Fever
Hot flashes
Injection-site edema
Injection-site irritation
Injection-site pain
Myalgia/Myositis/Myopathy/Myotoxicity
Thrombophlebitis
UROKINASE
Trade names: Abbokinase (Abbott); Ukidan
Indications: Acute myocardial infarction, coronary artery
thrombosis, pulmonary embolism
Category: Fibrinolytic; Plasminogen activator
Half-life: 10–20 minutes
Clinically important, potentially hazardous interactions
with: aspirin, bivalirudin, ibuprofen, indomethacin
Reactions
Skin
Angioedema (>10%)
(2001): Pechlaner C+, Blood Coagul Fibrinolysis 12(6), 491
Bullous dermatitis (hemorrhagic)
(1995): Ejaz AA+, Am J Nephrol 15, 178
Diaphoresis (10%)
(2001): Pechlaner C+, Blood Coagul Fibrinolysis 12(6), 491
Chills
Hypersensitivity