Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Other
Death
(2002): Avarello TP+, Neurol Sci 23, S55 (from contaminants)
Fever
(2002): Avarello TP+, Neurol Sci 23, S55
Note: Tryptophan is an essential amino acid. It is a precursor of
serotonin and is also converted to nicotinic acid and nicotinamide
TURMERIC
Scientific names: Curcuma aromatica; Curcuma domestica;
Curcuma longa; Curcuma xanthorrhiza
Family: Zingiberaceae
Trade and other common names: Calebin-A; Chiang Huang;
Curcumin; E100; Haridra; Indian Saffron; Jiang Huang; Yellow
Root; Yu Jin; Zedoary
Category: Anti-inflammatory; TNF inhibitor
Purported indications and other uses: Arthritis,
anticarcinogen, stimulant, carminative, amenorrhea, angina,
asthma, colorectal cancer, delirium, diarrhea, dyspepsia,
flatulence, hemorrhage, hepatitis, hypercholesterolemia,
hypertension, jaundice, mania, menstrual disorders, ophthalmia,
tendonitis. Topical: conjuctivitis, skin cancer, smallpox,
chickenpox, leg ulcers. Food coloring in cheese, margarine,
sweets, snack foods, cosmetics, essential oil in perfumes, culinary
spice
Half-life: N/A
Reactions
Skin
Allergic reactions (sic) (rare)
Dermatitis
(1997): Hata M+, Contact Dermatitis 36(2), 107
(1993): Futrell JM+, Cutis 52(5), 288
(1987): Goh CL+, Contact Dermatitis 17(3), 186
Note: Persons with symptoms of gallstones or obstruction of bile
passages should avoid turmeric
UNOPROSTONE
Synonym: UF-021
Trade name: Rescula (Novartis)
Indications: Open-angle glaucoma
Category: Prostaglandin
Half-life: 14 minutes
Reactions
Skin
Allergic reactions (sic) (1–10%)
Diaphoresis
Irritation
(1999): Hejkal TW+, Semin Ophthalmol 14, 114
Shivering
Mucosal
Xerostomia
(1998): Stewart WC+, JGlaucoma7, 388
(1996): Haria M+, Drugs Aging 9, 213
(1993): Azuma I+, Jpn J Ophthalmol 37, 514
Eyes
Eyelashes – hypertrichosis
(1999): Hejkal TW+, Semin Ophthalmol 14, 114
Eyelid edema
Ocular burning (10–25%)
(2003): Hommer A+, Br J Ophthalmol 87(5), 592 (with timolol)
Ocular edema
(2005): Arcieri ES+, Arch Ophthalmol 123(2), 186
Ocular erythema
(2001): Aung T+, Am J Ophthalmol 131(5), 636
Ocular pigmentation
(2002): Novack GD+, JAmGeriatrSoc50(5), 956
(2002): Stjernschantz JW+, Surv Ophthalmol 47, S162
(1999): Hejkal TW+, Semin Ophthalmol 14, 114
Ocular pruritus (10–25%)
Ocular stinging (10–25%)
(2003): Hommer A+, Br J Ophthalmol 87(5), 592 (with timolol)
Other
Myalgia/Myositis/Myopathy/Myotoxicity
URACIL/TEGAFUR
Synonyms: UFT; TS-1; Ftorafur
Trade name: Uftoral (Bristol-Myers Squibb)
Indications: Metastatic colorectal cancer
Category: Folic acid antagonist
Half-life: 6.5 hours
Clinically important, potentially hazardous interactions
with: allopurinol, cimetidine, clozapine, metronidazole,
phenytoin, warfarin
Note: Tegafur is a prodrug of fluorouracil
Reactions
URACIL/TEGAFUR 563
Skin
Acral erythema
(1997): Bastida J+, Acta Derm Venereol 77(1), 72
(1995): Jucgla A+, Arch Dermatol 131(3), 364
Dermatitis
(1990): Unda Urzaiz M+, Arch Esp Urol 43(2), 143
Dermatomyositis
(1997): Akiyama C+, Acta Derm Venereol 77(6), 490
Eczema
(1986): Horio T+, Photodermatol 3(3), 192
Edema
(1998): Mani S+, Ann Oncol 9(9), 1035
Hand–foot syndrome
(2000): Lin JK+, Jpn J Clin Oncol 30(11), 510 (2 cases)
(1997): Bastida J+, Acta Derm Venereol 77(1), 72
(1997): Rios-Buceta L+, Acta Derm Venereol 77(1), 80
(1995): Jucgla A+, Arch Dermatol 131(3), 364
(1991): Camps C+, Rev Clin Esp 188(3), 165
Keratoderma
(1998): Won YH+, Int J Dermatol 37(4), 315
(1995): Jucgla A+, Arch Dermatol 131(3), 364
Lupus erythematosus
(2001): Yoshimasu T+, Eur J Dermatol 11(1), 54
Mucha–Habermann disease
(1999): Kawamura K+, JDermatol26(3), 164
Palmar–plantar pigmentation
(1991): Llistosella E+, Cutis 48(3), 205
Photosensitivity
(1997): Usuki A+, Int J Dermatol 36(8), 604
(1986): Horio T+, Photodermatol 3(3), 192