Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

550 TRANDOLAPRIL
TRANDOLAPRIL
Trade names: Gopten; Mavik (Abbott); Odrik; Tarka (Abbott);
Udrik
Indications: Hypertension
Category: Angiotensin-converting enzyme inhibitor
Half-life: 24 hours
Clinically important, potentially hazardous interactions
with: amiloride, spironolactone, triamterene
Tarka is trandolapril and verapamil
Reactions
Skin
Angioedema (0.15%)
(2001): Cohen EG+, Ann Otol Rhinol Laryngol 110(8), 701 (64
cases)
(1996): Med Lett Drugs Ther 38, 104
Edema (>3%)
Pemphigus (3%)
Rash (sic) (>10%)
Mucosal
Xerostomia (>3%)
Other
Cough
(2003): Guay DR, Clin Ther 25(3), 713 (with verapamil)
(2001): Adigun AQ+, West Afr J Med 20(1), 46–7
(2001): Lee SC+, Hypertension 38(2), 166
Myalgia/Myositis/Myopathy/Myotoxicity (>3%)
Rhabdomyolysis
(2000): Gokel Y+, Am J Emerg Med 18(6), 738 (with verapamil)
TRANYLCYPROMINE
Trade names: Parnate; Siciton
Indications: Depression
Category: Antidepressant; Monoamine oxidase (MAO) inhibitor
Half-life: 2.5 hours
Clinically important, potentially hazardous interactions
with: amitriptyline, amoxapine, amphetamines, bupropion,
citalopram, clomipramine, cyproheptadine, desipramine,
dextroamphetamine, dextromethorphan, diethylpropion,
dopamine, doxepin, entacapone, ephedrine, epinephrine,
fluoxetine, fluvoxamine, imipramine, levodopa, mazindol,
meperidine, methamphetamine, nefazodone, nortriptyline,
paroxetine, phendimetrazine, phentermine, phenylephrine,
phenylpropanolamine, protriptyline, pseudoephedrine,
rizatriptan, sertraline, sibutramine, sumatriptan,
sympathomimetics, tramadol, tricyclic antidepressants,
trimipramine, tryptophan, tyramine-containing foods*,
venlafaxine, zolmitriptan
Skin
Diaphoresis
Edema (