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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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TOSITUMOMAB & IODINE 131<br />

Trade names: Bexxar (Corixa) (GSK); Iodine 131 Tositumomab<br />

(MDS Nordion); Tositumomab<br />

Indications: Non-Hodgkin lymphoma<br />

Category: Antineoplastic; Monoclonal antibody<br />

Half-life: 8.04 days<br />

Clinically important, potentially hazardous interactions<br />

with: None<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

Angioedema<br />

Carcinoma (skin)<br />

Diaphoresis (8%)<br />

Peripheral edema (9%)<br />

Pruritus<br />

Rash (sic) (17%)<br />

Other<br />

Abdominal pain (15%)<br />

Anaphylactoid reactions/Anaphylaxis<br />

Chills (29%)<br />

Cough (21%)<br />

Fever (37%)<br />

Hypersensitivity<br />

Infections (21%)<br />

Myalgia/Myositis/Myopathy/Myotoxicity (13%)<br />

(2006): Buchegger F+, Br J Cancer 94(12), 1770<br />

(2006): Visser OJ+, Bio<strong>Drug</strong>s 20(4), 201<br />

Pain (19%)<br />

Serum sickness<br />

TRAGACANTH GUM<br />

Scientific names: Astragalus gossypinus; Astragalus gummifer<br />

Family: Fabaceae; Leguminosae<br />

Trade <strong>and</strong> other common names: E413; Goat’s Thorn;<br />

Gummi Tragacanthae; Hog Gum<br />

Category: Food additive; Laxative<br />

Purported indications <strong>and</strong> other uses: Diarrhea. Ingredient in<br />

pharmaceuticals, foods, toothpaste, denture adhesives, emulsifier,<br />

binding agent, demulcent, stabilizer<br />

Half-life: N/A<br />

None<br />

Note: See also Astragalus root<br />

Reactions<br />

TRAMADOL<br />

Trade names: Contramal; Tadol; Tradol; Tramal; Tramed;<br />

Tramol; Tridol; Ultracet (Ortho-McNeil); Ultram (Ortho-<br />

McNeil); Zipan<br />

Indications: Pain<br />

Category: Opiate agonist<br />

Half-life: 6–7 hours<br />

Clinically important, potentially hazardous interactions<br />

with: citalopram, desflurane, fluoxetine, fluvoxamine, MAO<br />

inhibitors, nefazodone, phenelzine, tranylcypromine, venlafaxine<br />

Reactions<br />

TRAMADOL 549<br />

Skin<br />

Allergic reactions (sic) (

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