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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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TOLAZAMIDE*<br />

Trade names: Diabewas; Diadutos; Norglycin; Tolanase;<br />

Tolinase (Pfizer); Tolisan<br />

Indications: Non-insulin dependent diabetes type II<br />

Category: Sulfonylurea<br />

Half-life: 7 hours<br />

Clinically important, potentially hazardous interactions<br />

with: phenylbutazones<br />

Reactions<br />

Skin<br />

Dermatitis<br />

Diaphoresis<br />

Eczema<br />

(1985): Frosch PJ+, Contact Dermatitis 13, 272<br />

Erythema (0.4%)<br />

Exanthems (0.4%)<br />

Lichenoid eruption<br />

(1990): Franz CB+, JAmAcadDermatol22, 128<br />

(1984): Barnett JH+, Cutis 34, 542<br />

Lupus erythematosus<br />

Photosensitivity (1–10%)<br />

Pruritus (0.4%)<br />

Purpura<br />

Rash (sic) (1–10%)<br />

Urticaria (1–10%)<br />

Mucosal<br />

Tongue ulceration<br />

(1984): Barnett JH+, Cutis 34, 542<br />

Other<br />

Hepatotoxicity<br />

(1985): Nakao NL+, Gastroenterology 89(1), 192<br />

(1980): Bridges ME+, South Med J 73(8), 1072<br />

Porphyria cutanea tarda<br />

*Note: Tolazamide is a sulfonamide <strong>and</strong> can be absorbed<br />

systemically. Sulfonamides can produce severe, possibly fatal,<br />

reactions such as toxic epidermal necrolysis <strong>and</strong> Stevens–Johnson<br />

syndrome<br />

TOLAZOLINE<br />

Trade name: Priscoline (Novartis)<br />

Indications: Pulmonary hypertension in the newborn<br />

Category: Sulfonylurea<br />

Half-life: 3–10 hours (neonates)<br />

Clinically important, potentially hazardous interactions<br />

with: cimetidine<br />

Reactions<br />

Skin<br />

Dermatitis<br />

(1985): Frosch PJ+, Contact Dermatitis 13, 272<br />

Edema<br />

Exanthems<br />

(1989): Cambazard F+, Ann Dermatol Venereol (French) 116, 499<br />

Rash (sic)<br />

Urticaria<br />

Other<br />

Injection-site burning (>10%)<br />

TOLBUTAMIDE*<br />

Trade names: Abemin; Aglycid; Diaben; Diatol; Dolipol;<br />

Mobenol; Novo-Butamid; Orabet; Orinase (Pfizer); Rastinon<br />

Indications: Non-insulin dependent diabetes type II<br />

Category: Sulfonylurea<br />

Half-life: 4–25 hours<br />

Clinically important, potentially hazardous interactions<br />

with: aprepitant, phenylbutazones, prednisone<br />

Reactions<br />

Skin<br />

Allergic reactions (sic) (

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