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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Note: Cutaneous side-effects of beta-receptor blockaders are<br />

clinically polymorphous. They apparently appear after several months<br />

of continuous therapy. Atypical psoriasiform, lichen planus-like, <strong>and</strong><br />

eczematous chronic rashes are mainly observed. (1983): Hödl St, Z<br />

Hautkr (German) 1:58, 17<br />

TINIDAZOLE<br />

Trade names: Fasigyn; Tindamax (Presutti)<br />

Indications: Amebiasis, giardiasis, trichomoniasis<br />

Category: Antibiotic, nitroimidazole<br />

Half-life: 12-14 hours<br />

Clinically important, potentially hazardous interactions<br />

with: None<br />

Reactions<br />

Skin<br />

Angioedema<br />

(1983): Okhrimovich LM+, Vrach Delo L(8), 100<br />

Burning<br />

Diaphoresis<br />

Fixed eruption<br />

(1998): Thami GP+, Dermatology 196(3), 368<br />

(1990): Kanwar AJ+, Dermatologica 180(4), 277<br />

(1990): Mishra D+, Int J Dermatol 29(10), 740<br />

(1988): Jafferany M+, Int J Dermatol 27(4), 279<br />

(1987): Jafferany M+, J Pak Med Assoc 37(5), 136<br />

Pruritus<br />

Rash (sic)<br />

Urticaria<br />

Vasculitis<br />

(1983): Okhrimovich LM+, Vrach Delo L(8), 100<br />

Mucosal<br />

Oral c<strong>and</strong>idiasis<br />

Sialorrhea<br />

Stomatitis<br />

Tongue furry<br />

Tongue pigmentation<br />

Xerostomia<br />

Other<br />

Abdominal pain<br />

C<strong>and</strong>idiasis<br />

Fever<br />

Myalgia/Myositis/Myopathy/Myotoxicity<br />

TINZAPARIN<br />

Trade name: Innohep (Pharmion)<br />

Indications: Acute symptomatic deep vein thrombosis<br />

Category: Heparin, low molecular weight<br />

Half-life: 3–4 hours<br />

Clinically important, potentially hazardous interactions<br />

with: butabarbital<br />

Skin<br />

Abscess (

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