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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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538 TICARCILLIN<br />

TICARCILLIN<br />

Trade names: Ticar (GSK); Timentin*<br />

Indications: Various infections caused by susceptible organisms<br />

Category: Antibiotic, penicillin<br />

Half-life: 1.0–1.2 hours<br />

Clinically important, potentially hazardous interactions<br />

with: anticoagulants, ceftobiprole, cyclosporine, demeclocycline,<br />

doxycycline, methotrexate, minocycline, oxytetracycline,<br />

tetracycline<br />

*Note: Timentin is Ticarcillin + Clavulanic acid<br />

Reactions<br />

Skin<br />

Allergic reactions (sic)<br />

(1994): Pleasants RA+, Chest 106, 1124 (in patients with cystic<br />

fibrosis)<br />

Angioedema<br />

Bullous dermatitis<br />

Erythema multiforme<br />

Erythema nodosum<br />

Exanthems<br />

(1980): Brogden RN+, <strong>Drug</strong>s 20, 325 (1%)<br />

Exfoliative dermatitis<br />

Hematomas<br />

Jarisch–Herxheimer reaction (

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