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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Mucosal<br />

Oral ulceration<br />

(1987): High S, BMJ 294, 375<br />

Xerostomia (1–10%)<br />

Other<br />

Rhabdomyolysis<br />

(1989): Blake PG+, Nephron 53(1), 76<br />

TERCONAZOLE<br />

Synonym: triaconazole<br />

Trade names: Fungistat; Gyno-Terazol; Terazol (Ortho-<br />

McNeil); Tercospor<br />

Indications: Vulvovaginal c<strong>and</strong>idiasis<br />

Category: Antibiotic, triazole<br />

Half-life: N/A<br />

Reactions<br />

Skin<br />

Pruritus (2.3%)<br />

Toxic epidermal necrolysis<br />

(1998): Searles GE+, J Cutan Med Surg 3, 85 (from vaginal<br />

suppository)<br />

Mucosal<br />

Vulvovaginal burning (1–10%)<br />

Other<br />

Chills<br />

Fever<br />

(1994): Hyder SS+, South Med J 87(7), 762<br />

TERFENADINE<br />

Trade names: Alergist; Allerplus; Cyater; Ferdin; Teldane;<br />

Teldanex; Triludan<br />

Category: Histamine H1 receptor antagonist<br />

Half-life: 16–22 hours<br />

Clinically important, potentially hazardous interactions<br />

with: aprepitant, darunavir, devil’s claw, erythromycin,<br />

grapefruit juice, roxithromycin, trole<strong>and</strong>omycin<br />

Note: This drug has been withdrawn<br />

Reactions<br />

Skin<br />

Angioedema (

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