Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

518 SUMATRIPTAN
Other
Anaphylactoid reactions/Anaphylaxis
Hot flashes (>10%)
Hyperpyrexia
(1991): Multiple authors, NEnglJMed325, 316
Injection-site burning
(2006): Winner P+, Clin Ther 28(10), 1582 (5%)
Injection-site reactions (sic) (10–58%)
(2006): Wendt J+, Clin Ther 28(4), 517 (43%)
(1991): Multiple authors, NEnglJMed325, 316 (10–20%)
Myalgia/Myositis/Myopathy/Myotoxicity (1.8%)
(2007): Winner P+, Mayo Clin Proc 82(1), 61
SUNITINIB
Synonym: Synonym: SU11248
Trade name: Sutent (Pfizer)
Indications: Gastrointestinal stromal tumor, Metastatic renal cell
carcinoma
Category: Tyrosine kinase inhibitor
Half-life: 40–60 hours
Clinically important, potentially hazardous interactions
with: ketoconazole, rifampin
Reactions
Skin
Bullous dermatitis
(2006): Faivre S+, J Clin Oncol 24(1), 25 (7%) [R]
Edema
(2006): Faivre S+, J Clin Oncol 24(1), 25
Hand-foot syndrome (12–14%)
Peripheral edema (17%) [R]
Pigmentation
(2006): Faivre S+, J Clin Oncol 24(1), 25 (yellow) (30–33%)
Rash (sic) (14–38%)
Side effects (sic)
(2005): Robert C+, Lancet Oncol 6(7), 491
Xerosis (17%) [R]
Mucosal
Glossodynia (15%) [R]
Mucositis (29–53%)
Stomatitis
(2006): Faivre S+, J Clin Oncol 24(1), 25 (29–53%)
Hair
Hair – alopecia (5–12%)
Hair – pigmentation
(2006): Faivre S+, J Clin Oncol 24(1), 25 (yellow) (7%) [G]
Eyes
Epiphora (6%) [R]
Periorbital edema (7%) [R]
Other
Abdominal pain (20–33%)
Cough (8–17%)
Fever (15–18%)
Myalgia/Myositis/Myopathy/Myotoxicity (14–17%)
Neurotoxicity (10%) [R]
Pain (18%) [R]
Note: [G] = treated for Gastrointestinal stromal tumor; [R] =
treated for Metastatic renal cell carcinoma
TACRINE
Synonym: THA
Trade name: Cognex (First Horizon)
Indications: Dementia of Alzheimer’s disease
Category: Cholinesterase inhibitor
Half-life: 1.5–4 hours
Clinically important, potentially hazardous interactions
with: fluvoxamine, galantamine, ibuprofen
Reactions
Skin
Acne (