Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

510 SULFADOXINE
Necrosis (10%)
(1989): Ortel B+, Dermatologica 178, 39
(1985): Hernborg A, Lancet 1, 1072 (passim)
Pruritus
(1987): Groth H+, Schweiz Rundsch Med Prax (German) 76, 570
Purpura
(1985): Hernborg A, Lancet 1, 1072 (passim)
Pustules
Rash (sic) (10%)
Oral lichenoid eruption
(1989): Zain RB, Southeast Asian J Trop Med Public Health 20, 253
Oral ulceration
(1985): Hernborg A, Lancet 1, 1072
Stomatitis
(1985): Hernborg A, Lancet 1, 1072 (passim)
Urogenital ulceration
(1985): Hernborg A, Lancet 1, 1072
Eyes
Periorbital edema
Other
Anaphylactoid reactions/Anaphylaxis
Death
Hypersensitivity (>10%)
*Note: Sulfadoxine is a sulfonamide and can be absorbed
systemically. Sulfonamides can produce severe, possibly fatal,
reactions such as toxic epidermal necrolysis and Stevens–Johnson
syndrome
SULFAMETHOXAZOLE*
Trade names: Bactrim (Women First); Septra (Monarch);
Sinomin; Urobak
Indications: Various infections caused by susceptible organisms
Category: Antibiotic, sulfonamide; Folic acid antagonist
Half-life: 7–12 hours
Clinically important, potentially hazardous interactions
with: anticoagulants, cyclosporine, methotrexate, probenecid,
warfarin
Note: Sulfamethoxazole is commonly used in conjunction with
trimethoprim (see co-trimoxazole)
Reactions
Skin
Acute febrile neutrophilic dermatosis (Sweet’s syndrome)
(1996): Walker DC+, JAmAcadDermatol34, 918
(1989): Cobb MW, JAmAcadDermatol21, 339 (passim)
(1986): Su WPD+, Cutis 37, 167
Acute generalized exanthematous pustulosis (AGEP)
(2003): Anliker MD+, J Investig Allergol Clin Immunol 13(1), 66
(with co-trimoxazole)
(1995): Moreau A+, Int J Dermatol 34, 263 (passim)
Allergic reactions (sic)
(2004): Karpman E+, JUrol172(2), 448
(2002): Choquet-Kastylevsky G+, Curr Allergy Asthma Rep
2(1), 16
Angioedema (1–5%)
(1988): Fihn SD+, AnnInternMed108, 350 (1–5%)
Bullous dermatitis
(1989): Caumes E+, Presse Med (French) 18, 1708
Dermatitis
(1989): Atahan IL+, Br J Radiol 62, 1107 (at previously irradiated
area)
(1987): Vukelja SJ+, Cancer Treat Rep 71, 668 (at previously
irradiated area)
(1984): Shelley WB+, JAmAcadDermatol11, 53 (at site of
previous sunburn)
Erythema multiforme
(1997): Rieder MJ+, Pediatr Infect Dis J 16, 1028 (70% in
children with HIV)
(1991): Tilden ME+, Arch Ophthalmol 109, 67
(1990): Chan HL+, Arch Dermatol 126, 43
(1989): Alanko K+, Acta Derm Venereol (Stockh) 69, 223
(1988): Hira SK+, JAmAcadDermatol19, 451
(1988): Platt R+, JInfectDis158, 474
(1987): Penmetcha M, BMJ 295, 556
(1987): Schöpf E, Infection 15 (Suppl 5P), S254
(1985): Heer M+, Gastroenterology 88, 1954
(1982): Brettle RP+, JInfect4, 149
Erythema nodosum
Erythroderma
Exanthems (1–5%)
(1998): Hattori N+, JDermatol25, 269
(1997): Caumes E+, Arch Dermatol 133, 465