Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Reactions
Skin
Allergic reactions (sic)
(2002): Smith JG, Mobile, AL (Klaron & Sulfacet-R) (from
Internet) (observations 2 cases)
(2000): Blumenthal HL, Beachwood, OH (Novacet Lotion)
(personal case) (observation)
Dermatomyositis
Edema
Erythema
Erythema multiforme
(1985): Genvert GI+, Am J Ophthalmol 99(4), 465 (topical)
Exfoliative dermatitis (1–10%)
Lupus erythematosus – dermatomyositis
Photosensitivity
Pruritus
Stevens–Johnson syndrome (1–10%)
Toxic epidermal necrolysis (1–10%)
(2003): Spencer L, Crawfordsville, IN (from Internet)
(observation) (from topical Silvadene)
Eyes
Corneal opacity
(1984): Tabbara KF+, Am J Ophthalmol 98(3), 378
Keratopathy
(1986): Grossniklaus HE+, Ophthalmology 93(2), 260
Ocular burning
Ocular stinging
Other
Death
Hypersensitivity
Infections
SULFADIAZINE*
Trade names: Coptin; Microsulfon
Indications: Various infections caused by susceptible organisms
Category: Antibiotic, sulfonamide
Half-life: 17 hours
Clinically important, potentially hazardous interactions
with: anticoagulants, cyclosporine, methotrexate
Reactions
Skin
Allergic reactions (sic)
(1991): de la Hoz Caballer B+, J Allergy Clin Immunol 88, 137
Erythema multiforme
(1983): Lockhart SP+, Burns Incl Therm Inj 10, 9
Exanthems
(1984): Finland M+, JAMA 251, 1467
Exfoliative dermatitis
Fixed eruption (12%)
(2004): Tornero P+, Contact Dermatitis 51(2), 57
(1991): Thankappen TP+, Int J Dermatol 30, 867 (12.4%)
Lupus erythematosus
Photosensitivity (>10%)
Pigmentation
(1985): Dupuis LL+, JAmAcadDermatol12, 1112
Pruritus (>10%)
Purpura
Rash (sic) (>10%)
Stevens–Johnson syndrome (1–10%)
(1999): Carrion-Carrion C+, Ann Pharmacother 33, 379 (fatal)
(in AIDS patient)
Toxic epidermal necrolysis (1–10%)
(1993): Correia O+, Dermatology 186, 32
Urticaria
(2005): Chen QK+, World J Gastroenterol 11(16), 2462 (2 cases)
Mucosal
Sialadenitis
(1997): Anibarro B+, Ann Pharmacother 31(1), 59
Stomatitis
Eyes
Periorbital edema
Other
Anaphylactoid reactions/Anaphylaxis
(2001): Stephens R+, Br J Anaesth 87(2), 306 (with
chlorhexidine)
Chills
Death
DRESS syndrome
(2005): Michel F+, Joint Bone Spine 72(1), 82
Hypersensitivity
(2005): Orita M+, Nippon Shokakibyo Gakkai Zasshi 102(5), 600
(2001): Morand JJ+, Ann Dermatol Venereol 128(12), 1351
(1987): Volckaert A+, Acta Clin Belg 42, 381
(1985): Jia XM, Chung Hua Cheng Hsing Shao Shang Wai Ko Tsa
Chih (Chinese) 1, 232
Nephrotoxicity
(2006): Hyvernat H+, Presse Med 35(3 Pt 1), 423
(2000): Crespo M+, Clin Nephrol 54(1), 68
Serum sickness (