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Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

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Glossitis (2%)<br />

Oral mucosal eruption<br />

Oral ulceration<br />

Stomatitis<br />

Tongue black<br />

Hair<br />

Hair – hypertrichosis<br />

(1992): Shelley WB+, Advanced Dermatologic Diagnosis WB<br />

Saunders, 725 (passim)<br />

Other<br />

Anaphylactoid reactions/Anaphylaxis<br />

(2002): Romano A+, Allergy 57(11), 1087<br />

DRESS syndrome<br />

(2004): Passeron T+, Acta Derm Venereol 84(1), 92<br />

Embolia cutis medicamentosa (Nicolau syndrome)<br />

(2003): Reding EL+, JAmAcadDermatol48(3), 472<br />

Injection-site granuloma<br />

Injection-site reactions (sic)<br />

Nephrotoxicity<br />

(2002): de Jager P+, Int J Tuberc Lung Dis 6(7), 622<br />

Rhabdomyolysis<br />

(1992): Nakahara Y+, Nippon Jinzo Gakkai Shi 34(11), 1233<br />

STREPTOZOCIN<br />

Trade name: Zanosar (Gensia)<br />

Indications: Carcinoma of the pancreas, carcinoid tumor,<br />

Hodgkin’s disease<br />

Category: Alkylating agent<br />

Half-life: 35 minutes<br />

Clinically important, potentially hazardous interactions<br />

with: aldesleukin<br />

Reactions<br />

Skin<br />

Edema<br />

Exanthems<br />

Pruritus<br />

Purpura<br />

Toxic epidermal necrolysis<br />

Other<br />

Injection-site erythema<br />

Injection-site necrosis<br />

(1987): Dufresne RG, Cutis 39, 197<br />

Injection-site pain (1–10%)<br />

Nephrotoxicity<br />

(2001): Kintzel PE, <strong>Drug</strong> Saf 24(1), 19<br />

(1988): Hricik DE+, Am J Med 84(1), 153<br />

SUCCIMER<br />

Synonyms: dimercaptosuccinic acid; DMSA<br />

Trade name: Chemet (Sanofi-Aventis)<br />

Indications: Heavy metal poisoning<br />

Category: Chelator<br />

Half-life: 2 days<br />

Clinically important, potentially hazardous interactions<br />

with: other chelating agents<br />

Reactions<br />

Skin<br />

Exanthems (11%)<br />

Pruritus (11%)<br />

Rash (sic) (

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