Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

506 STAVUDINE
Myalgia/Myositis/Myopathy/Myotoxicity (32%)
(2000): Miller KD+, AnnInternMed133, 192
STREPTOKINASE
Trade names: Kabikinase (Pfizer); Streptase (AstraZeneca)
Indications: Pulmonary embolism, acute myocardial infarction
Category: Fibrinolytic
Half-life: 83 minutes
Clinically important, potentially hazardous interactions
with: bivalirudin
Reactions
Skin
Allergic reactions (sic) (4.4%)
(2003): Janousek S, Vnitr Lek 49(11), 880
(2001): Toquero J+, Rev Esp Cardiol 54(10), 1225
(1998): Stephens MB+, Postgrad Med 103, 89
(1997): Cannas S+, G Ital Cardiol (Italian) 27, 278
Angioedema (>10%)
(1994): Cooper JP+, Postgrad Med J 70, 592
Diaphoresis (1–10%)
Exanthems (1–5%)
(1990): Goa KL+, Drugs 39, 693
Hematomas
(2006): Cakici N+, Anadolu Kardiyol Derg 6(4), 380
Pruritus (1–10%)
Purpura
Rash (sic) (1–10%)
Urticaria (1–5%)
(1990): Goa KL+, Drugs 39, 693
Vasculitis
(1994): Penswick J+, BMJ 309, 378
(1991): Patel A+, JAmAcadDermatol24, 652
(1988): Davidson JR+, Clin Exp Rheumatol 6, 381
(1988): Ong AC+, Int J Cardiology 21, 71
(1988): Sorber WA+, Cutis 42(1), 57
(1986): Manoharan A+, Aust N Z J Med 16, 815
(1985): Thompson RF+, Clin Pharm 4, 383
Mucosal
Stomatitis (following local application)
Tongue edema (with hemorrhagic swelling)
Eyes
Periorbital edema (>10%)
Other
Anaphylactoid reactions/Anaphylaxis (