Drug Eruption and Interactions - PHARMACEUTICAL REVIEW

Pruritus
(1997): Golsch S+, Hautarzt 48, 249
Mucosal
Xerostomia
(1997): Med Lett Drugs Ther 39, 107
Hair
Hair – alopecia
(2001): Parker V+, Can J Psychiatry 46(1), 77
Other
Hepatotoxicity
(2006): Teschke R, Dtsch Med Wochenschr 131(34-3), 1880 (with
Kava)
Hypersensitivity
Side effects (sic)
(1999): Tinsley JA, Minn Med 82(5), 29
Note: St John’s wort is a natural source of flavoring in Europe.
Although not indigenous to Australia, and long considered a weed, St
John’s wort is now grown there as a cash crop and produces 20% of
the world’s supply
STANOZOLOL
Trade names: Menabol; Stromba; Winstrol (Ovation)
Indications: Hereditary angioedema
Category: Anabolic steroid
Half-life: N/A
Clinically important, potentially hazardous interactions
with: anticoagulants, warfarin
Reactions
Skin
Acne (>10%)
(1995): Helfman T+, JAmAcadDermatol32, 254
Edema
Exanthems
Folliculitis
(1995): Helfman T+, JAmAcadDermatol32, 254
Pigmentation (1–10%)
Rosacea
(1995): Helfman T+, JAmAcadDermatol32, 254
Seborrheic dermatitis
(1995): Helfman T+, JAmAcadDermatol32, 254
Urticaria
Hair
Hair – alopecia (in women)
Hair – hirsutism (in women)
(1995): Helfman T+, JAmAcadDermatol32, 254
(1987): Sheffer AL+, J Allergy Clin Immunol 80, 855
Other
Chills (1–10%)
Death
(2001): Fineschi V+, Arch Pathol Lab Med 125(2), 253 (abuse)
(1999): Sullivan ML+, J Emerg Med 17(5), 851 (abuse)
Gynecomastia (>10%)
(1995): Helfman T+, JAmAcadDermatol32, 254
Hepatotoxicity
(2002): Stimac D+, J Clin Gastroenterol 35(4), 350 (abuse)
(2000): Segal S+, JAmAcadDermatol43(3), 558
Hypersensitivity
Nephrotoxicity
(1999): Habscheid W+, Dtsch Med Wochenschr 124(36), 1029
(1994): Yoshida EM+, CMAJ 151(6), 791 (abuse)
STAR ANISE (Chinese)
Scientific name: Illicium verum
Family: Illiciaceae
Trade and other common names: Anisi stellati fructus;
Badiana; Chinese anise; Eight-horned anise
Category: Antimycobacterial; Insecticide
Purported indications and other uses: Bronchitis, colic,
cough, flatulence, menstrual complaints, respiratory tract
inflammation. Culinary spice, fragrance component in cosmetics
Half-life: N/A
Note: Star anise preparations are sometimes contaminated with
highly poisonous Japanese star anise (Illicium anisatum)
Star anise contains a compound used in the manufacture of Tamiflu
Skin
Dermatitis
Erythema
Scaling
Sensitization
STAVUDINE
Reactions
Synonym: d4T
Trade name: Zerit (Bristol-Myers Squibb)
Indications: Human immunodeficiency virus (HIV)
Category: Antiretroviral; Nucleoside analog reverse
transcriptase inhibitor
Half-life: 1.44 hours
Reactions
STAVUDINE 505
Skin
Allergic reactions (sic) (9%)
Diaphoresis (19%)
Neutrophilic eccrine hidradenitis
(1998): Krischer J+, JDermatol25, 199
Rash (sic) (~40%)
Other
Chills (50%)
Death
(2001): Hwang SW+, Singapore Med J 42(6), 247 (2 cases) (with
didanosine)
Gynecomastia
(2001): Aquilina C+, IntJSTDAIDS12(7), 481 (with didanosine)
(2001): Manfredi R+, Ann Pharmacother 35(4), 438 (with
didanosine)
(2001): Manfredi R+, Ann Pharmacother 35(4), 438 (with
lamivudine) (3 cases)
(1998): Melbourne KM+, Ann Pharmacother 32, 1108
Lipoatrophy
(2004): McComsey GA+, Clin Infect Dis 38(2), 263
(2001): Lichtenstein KA+, AIDS 15(11), 1389
Lipodystrophy
(2002): Bernasconi E+, J Acquir Immune Defic Syndr 31(1), 50
(2002): Reid S, Can Adv Drug Reaction Newsletter 12, 5
(2001): Aquilina C+, IntJSTDAIDS12(7), 481 (with didanosine)
(2001): Arpadi SM+, J Acquir Immune Defic Syndr 27(1), 30
(2001): Bogner JR+, J Acquir Immune Defic Syndr 27(3), 237
(2001): van der Valk M+, AIDS 15(7), 847
(1999): Ruel M+, Ann Med Interne (Paris) (French) 150, 269